OBJECTIVE: To estimate the potential global economic productivity loss associated with the existing burden of visual impairment from uncorrected refractive error (URE). METHODS: Conservative assumptions and national population, epidemiological and economic data were used to estimate the purchasing power parity-adjusted gross domestic product (PPP-adjusted GDP) loss for all individuals with impaired vision and blindness, and for individuals with normal sight who provide them with informal care. FINDINGS: An estimated 158.1 million cases of visual impairment resulted from uncorrected or undercorrected refractive error in 2007; of these, 8.7 million were blind. We estimated the global economic productivity loss in international dollars (I)associatedwiththisburdenatI 427.7 billion before, and I268.8billionafter,adjustmentforcountry−specificlabourforceparticipationandemploymentrates.Withthesameadjustment,butassumingnoeconomicproductivityforindividualsaged>50years,weestimatedthepotentialproductivitylossatI 121.4 billion. CONCLUSION: Even under the most conservative assumptions, the total estimated productivity loss, in I,associatedwithvisualimpairmentfromUREisapproximatelyathousandtimesgreaterthantheglobalnumberofcases.Thecostofscalingupexistingrefractiveservicestomeetthisburdenisunknown,butifeachaffectedindividualweretobeprovidedwithappropriateeyeglassesforlessthanI 1000, a net economic gain may be attainable