Variabilidade da frequência cardíaca como recurso em fisioterapia: análise de periódicos nacionais

INTRODUCTION: The autonomic nervous system (ANS) could be investigated in a noninvasive way by the heart rate variability analysis (HRV) which has contributed to several health areas such as physiotherapy. OBJECTIVE: To gather information regarding the use of HRV on physiotherapy aims at providing an update of the findings for the area on journals of national circulation. MATERIALS AND METHODS: The journals of national circulation classified as greater than B2 or B2 and with free access and complete texts in some internet sites were searched on 21 area WebQualis resulting on selection of Revista Brasileira de Fisioterapia, Fisioterapia e Pesquisa and Fisioterapia em Movimento using the keywords: autonomic nervous system, sympathetic nervous system, physiotherapy and heart rate variability. RESULTS: The search resulted in 19 articles being 17 clinical trials and two case reports. CONCLUSION: The HRV has been used as a resource of interventions evaluation, as pathological conditions common to clinical practice investigation and to physiological conditions interpretation in physiotherapy. The HRV is principally used to the cardiorespiratory specialty of physiotherapy.INTRODUÇÃO: O sistema nervoso autônomo (SNA) pode ser investigado de forma não invasiva a partir da análise da variabilidade da frequência cardíaca (VFC) e sua utilização para avaliação do SNA tem contribuído com várias áreas da saúde, dentre elas, a fisioterapia. OBJETIVOS: Reunir estudos publicados em periódicos de circulação nacional da área que abordassem a utilização da VFC em fisioterapia, a fim de fornecer uma atualização dos achados para a área. MATERIAIS E MÉTODOS: Foram selecionados, na lista de periódicos do WebQualis da área 21, todos os periódicos de circulação nacional que utilizam a palavra fisioterapia em seu título, com disponibilidade livre e textos completos em algum sítio da internet e que possuíssem classificação maior ou igual a B2. Com esses critérios, foram selecionados artigos das seguintes revistas: Revista Brasileira de Fisioterapia, Fisioterapia e Pesquisa e Fisioterapia em Movimento. Para essa busca, foram utilizados os descritores: sistema nervoso autônomo, sistema nervoso simpático, fisioterapia e variabilidade da frequência cardíaca. RESULTADOS: A busca resultou em 19 artigos, sendo 17 ensaios clínicos e dois relatos de caso. CONCLUSÃO: A VFC tem sido utilizada no âmbito da fisioterapia como recurso para avaliação de intervenções fisioterapêuticas, como forma de investigação de condições patológicas comuns à prática clínica e para interpretação de condições fisiológicas. A sua utilização é feita principalmente pela especialidade de fisioterapia cardiorrespiratória

Sequence Features and Transcriptional Stalling within Centromere DNA Promote Establishment of CENP-A Chromatin

Centromere sequences are not conserved between species, and there is compelling evidence for epigenetic regulation of centromere identity, with location being dictated by the presence of chromatin containing the histone H3 variant CENP-A. Paradoxically, in most organisms CENP-A chromatin generally occurs on particular sequences. To investigate the contribution of primary DNA sequence to establishment of CENP-A chromatin in vivo, we utilised the fission yeast Schizosaccharomyces pombe. CENP-ACnp1 chromatin is normally assembled on ∼10 kb of central domain DNA within these regional centromeres. We demonstrate that overproduction of S. pombe CENP-ACnp1 bypasses the usual requirement for adjacent heterochromatin in establishing CENP-ACnp1 chromatin, and show that central domain DNA is a preferred substrate for de novo establishment of CENP-ACnp1 chromatin. When multimerised, a 2 kb sub-region can establish CENP-ACnp1 chromatin and form functional centromeres. Randomization of the 2 kb sequence to generate a sequence that maintains AT content and predicted nucleosome positioning is unable to establish CENP-ACnp1 chromatin. These analyses indicate that central domain DNA from fission yeast centromeres contains specific information that promotes CENP-ACnp1 incorporation into chromatin. Numerous transcriptional start sites were detected on the forward and reverse strands within the functional 2 kb sub-region and active promoters were identified. RNAPII is enriched on central domain DNA in wild-type cells, but only low levels of transcripts are detected, consistent with RNAPII stalling during transcription of centromeric DNA. Cells lacking factors involved in restarting transcription-TFIIS and Ubp3-assemble CENP-ACnp1 on central domain DNA when CENP-ACnp1 is at wild-type levels, suggesting that persistent stalling of RNAPII on centromere DNA triggers chromatin remodelling events that deposit CENP-ACnp1. Thus, sequence-encoded features of centromeric DNA create an environment of pervasive low quality RNAPII transcription that is an important determinant of CENP-ACnp1 assembly. These observations emphasise roles for both genetic and epigenetic processes in centromere establishment

Energy-scaling behavior of intrinsic transverse-momentum parameters in Drell-Yan simulation

Data Availability: Release and preservation of data used by the CMS Collaboration as the basis for publications is guided by the CMS data preservation, re-use, and open access policy https://dx.doi.org/10.7483/OPENDATA.CMS.7347.JDWH .A preprint version of the article is available on arXiv, arXiv:2409.17770v2 [hep-ph] (https://arxiv.org/abs/2409.17770). [v2] Tue, 8 Apr 2025 23:23:48 UTC (450 KB). Comments: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/GEN-22-001 (CMS Public Pages). Subjects: High Energy Physics - Phenomenology (hep-ph); High Energy Physics - Experiment (hep-ex). Report numbers: CMS-GEN-22-001, CERN-EP-2024-216An analysis is presented based on models of the intrinsic transverse momentum (intrinsic ) of partons in nucleons by studying the dilepton transverse momentum in Drell-Yan events. Using parameter tuning in event generators and existing data from fixed-target experiments and from hadron colliders, our investigation spans 3 orders of magnitude in center-of-mass energy and 2 orders of magnitude in dilepton invariant mass. The results show an energy-scaling behavior of the intrinsic parameters, independent of the dilepton invariant mass at a given center-of-mass energy.We congratulate our colleagues in the CERN accelerator departments for the excellent performance of the LHC and thank the technical and administrative staffs at CERN and at other CMS institutes for their contributions to the success of the CMS effort. In addition, we gratefully acknowledge the computing centers and personnel of the Worldwide LHC Computing Grid and other centers for delivering so effectively the computing infrastructure essential to our analyses. Finally, we acknowledge the enduring support for the construction and operation of the LHC, the CMS detector, and the supporting computing infrastructure provided by the following funding agencies: SC (Armenia), BMBWF and FWF (Austria); FNRS and FWO (Belgium); CNPq, CAPES, FAPERJ, FAPERGS, and FAPESP (Brazil); MES and BNSF (Bulgaria); CERN; CAS, MoST, and NSFC (China); MINCIENCIAS (Colombia); MSES and CSF (Croatia); RIF (Cyprus); SENESCYT (Ecuador); ERC PRG, RVTT3 and MoER TK202 (Estonia); Academy of Finland, MEC, and HIP (Finland); CEA and CNRS/IN2P3 (France); SRNSF (Georgia); BMBF, DFG, and HGF (Germany); GSRI (Greece); NKFIH (Hungary); DAE and DST (India); IPM (Iran); SFI (Ireland); INFN (Italy); MSIP and NRF (Republic of Korea); MES (Latvia); LMTLT (Lithuania); MOE and UM (Malaysia); BUAP, CINVESTAV, CONACYT, LNS, SEP, and UASLP-FAI (Mexico); MOS (Montenegro); MBIE (New Zealand); PAEC (Pakistan); MES and NSC (Poland); FCT (Portugal); MESTD (Serbia); MCIN/AEI and PCTI (Spain); MOSTR (Sri Lanka); Swiss Funding Agencies (Switzerland); MST (Taipei); MHESI and NSTDA (Thailand); TUBITAK and TENMAK (Turkey); NASU (Ukraine); STFC (United Kingdom); DOE and NSF (USA)

The CMS Statistical Analysis and Combination Tool: Combine

Metrics: https://link.springer.com/article/10.1007/s41781-024-00121-4/metricsThis paper describes the Combine software package used for statistical analyses by the CMS Collaboration. The package, originally designed to perform searches for a Higgs boson and the combined analysis of those searches, has evolved to become the statistical analysis tool presently used in the majority of measurements and searches performed by the CMS Collaboration. It is not specific to the CMS experiment, and this paper is intended to serve as a reference for users outside of the CMS Collaboration, providing an outline of the most salient features and capabilities. Readers are provided with the possibility to run Combine and reproduce examples provided in this paper using a publicly available container image. Since the package is constantly evolving to meet the demands of ever-increasing data sets and analysis sophistication, this paper cannot cover all details of Combine. However, the online documentation referenced within this paper provides an up-to-date and complete user guide.CERN (European Organization for Nuclear Research)STFC (United Kingdom)Marie-Curie programme and the European Research Council and Horizon 2020 Grant, contract Nos. 675440, 724704, 752730, 758316, 765710, 824093, 101115353, 101002207, and COST Action CA16108 (European Union); the Leventis Foundation; the Alfred P. Sloan Foundatio

High eccentric strength training reduces heart rate variability in healthy older men

Background: Evaluation of non-pharmacological therapies that improve autonomic control of the heart rate in older subjects has a clinical significance, because reduced heart rate variability (HRV) can be associated with higher cardiovascular morbidity and mortality rates. Objective: To investigate if strength training improves cardiac autonomic control in healthy older men. Methods: The HRV of nine older healthy men (mean age 62 (2.0) years) was evaluated before and after 12 weeks of isokinetic eccentric strength training (2 days/week, 2-4 sets of 8-12 repetitions at 75-80% peak torque, involving knee flexion and extension. Electrocardiogram was continuously recorded for 15 min at rest, in supine and seated positions, before and after the strength training period. To estimate strength gains, the eccentric peak torque of the dominant leg was measured at 60 degrees/s by the same isokinetic dynamometer. Results: Mean systolic blood pressure decreased (123.78 (8.3) to 117.67 (10.2) mmHg, p < 0.05) and peak torque increased ( extension 210.02 (38.5) to 252.71 (60.9) N. m; flexion: 117.56 (25.1) to 132.96 (27.3) N. m, p < 0.05) after the strength training. The frequency domain indices showed a significant training effect (p < 0.05), since low frequency in normalised units and low frequency/ high frequency ratio increased (supine, 57 (14) to 68 (14), 1.56 (0.85) to 2.35 (1.48); seated, 65 (15) to 74 (8.0), 2.48 (1.09) to 3.19 (1.31), respectively), and high frequency in normalised units decreased (supine, 43 (14) to 32 (14); seated, 35 (15) to 26 (8)) after the training period. Conclusion: The results of the present investigation suggest that high eccentric strength training performed by healthy older men increases peak torque and reduces systolic blood pressure. However, an autonomic imbalance towards sympathetic modulation predominance was induced by an unknown mechanism.42

Economic viability of the piaucu Leporinus macrocephalus (Garavello & Britski, 1988) production

Brazilian fish farms presented an accelerated development during the early 90's, mainly because of the increase in fee-fishing operations. To meet the demand of this market, fish production and supply became excessive and, as a consequence, the number of fee-fishing operations, farmers and the final selling price, decreased. This study analyzes the technical aspects, production cost, profitability and economic viability of the production of piaucu (L. macrocephalus) in ponds, based on information from a rural property. Feeding and fingerling costs amount to approximately 47.1 % of the total production cost, representing together with the final selling price the most important factor affecting profitability. The payback period was 8.3 years, the liquid present value US$ 291.07, the internal return margin 9%, and the income-outcome ratio was 1.01, which represents an unattractive investment as a projection based on current conditions. The improvement in productive efficiency enhances the economic valuation index, and that the relative magnitude of cost and income are the most important points for the economic viability of the studied farm

Análise da resposta da freqüência cardíaca durante a realização de exercício isocinético excêntrico de grupamento extensor de joelho

Objetivo: Investigar a magnitude da resposta da freqüência cardíaca durante o exercício isocinético excêntrico do grupamento extensor do joelho, em diferentes velocidades angulares. Materiais e Métodos: Dez voluntários jovens, sadios e ativos foram submetidos a contração excêntrica máxima do grupo extensor do joelho dominante. Foi utilizado um dinamômetro isocinético, nas velocidades de 30º/s, 60º/s e 120º/s, ordenadas aleatoriamente. A FC foi obtida batimento a batimento, na derivação eletrocardiográfica MC5 modificada, durante 60s pré-exercício, durante o tempo de contração, sendo cinco repetições para cada velocidade, e por 120s após o esforço. Foram calculadas: FC média dos 60s pré-exercício, FC pico atingida ao final do esforço, e variação da FC (DFC), além dos valores do pico de torque. Também foram comparados valores da FC média dos 6 minutos pré-exercício com os 6 minutos de recuperação. Os resultados foram comparados pelo teste de Friedman com post hoc de Dunn. O nível de significância estabelecido foi de 5%. Resultados: Não foram observadas diferenças estatisticamente significantes entre os valores medianos da FC de repouso (68bpm para 30º/s e 60º/s, 70bpm para 120º/s), FC pico (107bpm para 30º/s, 103 em 60º/s e 100bpm em 120º/s) e DFC (37bpm para 30º/s, 35bpmem 60º/s e 27bpm para 120ºs), além do pico de torque (209,5N/m para 30º/s, 217,2N/m em 60º/s e 210,6N/m para 120º/s). A mediana dos valores de FC anteriores ao esforço foi semelhante aos de recuperação (67bpm). Conclusão:A magnitude de resposta da FC foi semelhante, durante atividade muscular excêntrica, indicando uma mesma sobrecarga cardíaca, independente da velocidade angular realizada