Characterisation of disulfide-rich peptides exploring potential wound healing properties

Rozita Takjoo explored the potential of peptides as wound healing agents. She identified a bioactive region involved in cell proliferation and provided insight into the evolution of a disulfide-rich motif. These outcomes are likely to facilitate future drug development studies aimed at developing novel wound healing agents for diabetic ulcers

The relationships between personal values, moral foundations, religiosity and identity styles among adolescents

Ziel dieser Studie war die Untersuchung der Beziehungen zwischen persönlichen Werten, Moralprinzipien, Religiösität und identitätsstil der Jugendlichen. Dafür wurden 330 männlichen Schülern Berzonsky Identity Styles Inventory (ISI), Schwartz Value Survey (1994), Moral Foundations Questionnaire (MFQ), und the Post-Critical Belief Scale (PCBS) vorgegeben. Die Daten wurden dann mittels Pearson Korrelation Koefficient und multiple regression analysis analysiert. Die Forschungsergebnisse zeigten eine signifikant positive Korrelation zwischen dem informativen Identitätsstil und dem symbolischen religiösen Denken. Diffuses/Vermeidungs-Identitätsstil war positiv verbunden mit dem Relativistischen Denken und der oberflächlichen Ablehnung der Religion, und war negativ korreliert mit dem Transzendenz-inklusiven Glauben. Die persönlichen Werte der Tradition und Wohltätigkeit waren positive korreliert mit Transzendenz-inklusiven Glauben. Außerdem zeigten alle Moralitätsarten außer “care/harm” (sich um anderen kümmern, Nächstenliebe) eine signifikant negative Korrelation mit oberflächlicher Ablehnung der Religion. Die eher skeptischen Schüler zeigten einen diffusen/vermeidungs-Identitätsstil. Sie versuchen eine tiefere Auseinandersetzung bzw. Konfrontation mit den religiösen Fragen und Normen in einem religiösen Land wie Iran zu vermeiden oder verschieben diese Auseinandersetzung auf eine spätere Zeit.The aim of this study was to examine the relationship between values, moral foundations, religiosity, and identity styles among adolescents. Therefore, high school male students were selected by cluster sampling method and were administered with Berzonsky Identity Styles Inventory (ISI), Schwartz Value Survey , Moral Foundations Questionnaire (MFQ), and the Post-Critical Belief Scale (PCBS). Data were analyzed using Pearson correlation coefficient and multiple regression analysis. Results showed a significant positive correlation between informative identity style and symbolic religious thinking, while diffuse/avoidant identity style was associated with relativism and literal disaffirmation and also exhibited a significant negative correlation with inclusion of transcendence beliefs. Further, the results showed that the personal values of tradition and benevolence were associated with the beliefs of inclusion of transcendence (symbolic and literal affirmation). All of the moral foundations except care/harm had a significant negative association with literal disaffirmation. The sceptic students with higher scores in relativism and literal disaffirmation seem to have diffuse/avoidant identity style, avoiding or postponing the more profound confrontation with religious questions and norms in a religious country such as Iran.

(Butan-2-ol-κO)[2-({(ethyl­sulfan­yl)[2-(2-oxidobenzyl­idene-κO)hydrazinyl­idene-κN 2]meth­yl}imino­meth­yl)phenolato-κO]dioxidouranium(VI)

The U atom in the title complex, [U(C17H15N3O2S)O2(C4H10O)], exists within a distorted penta­gonal–bipyramidal geometry where the oxide O atoms occupy axial positions [O—U—O = 179.61 (18)°] and the penta­gonal plane is defined by the N2O2 atoms of the tetra­dentate Schiff base ligand and the O atom of the butan-2-ol mol­ecule. In the crystal, centrosymmetric aggregates are formed via pairs of hy­droxy–phenoxide O—H⋯O hydrogen bonds. The azomethine C=N atoms, the ethyl­thiolyl group and the butyl group of the butan-2-ol mol­ecule are disordered over two positions in a 0.668 (3):0.332 (3) ratio

The Relationship of Cognitive Emotion Regulation and Integrative Self-knowledge with Conformity

Introduction: conformity is the change of behavior or attitude influenced by real or imagined presence of others. The purpose of this study is to investigate the relationship between cognitive emotion, integrative self-knowledge and conformity among young people in Red Crescent Society in West Azerbaijan. Methods: Data were analyzed using Pearson correlation coefficient and hierarchical regression analysis. 260 members of Red Crescent Society in West Azerbaijan were selected through random cluster sampling method. Participants completed group conformity L-72 (GCL-72), cognitive emotion regulation (CERQ) and integrative self-knowledge (ISQ) questionnaires. Results: The results showed there was a negative significant relationship between integrative selfknowledge and adaptive strategies of cognitive emotion regulation with conformity. (p<0.01). There was a significant negative relationship between integrative self-knowledge and conformity (p<0.01) and). There was also a significant negative relationship between integrative selfknowledge and conformity (p<0.01). The results of hierarchical regression analysis showed that integrative self-knowledge and adaptive strategies of cognitive emotion regulation could explain 23% of conformity variance significantly (p<0.01) and Partial Beta Coefficient of integrative self- knowledge (P<0.01) and adaptive strategies (P<0.01) are respectively (-0.074) and (0.156). Conclusion: Overall the results showed integrative self-knowledge and adaptive strategies of cognitive emotion predict conformity Declaration of Interest: None.  

(Dimethyl sulfoxide-κO)[2-({(ethyl­sulfan­yl)[2-(2-oxidobenzyl­idene-κO)hydrazin­yl­idene-κN 2]meth­yl}­imino­meth­yl)­phenol­ato-κO]dioxidouranium(VI)

The UVI atom in the title complex, [U(C17H15N3O2S)O2(C2H6OS)], exists within a distorted penta­gonal–pyramidal geometry where the oxide atoms occupy axial positions [O—U—O = 177.84 (14)°] and the penta­gonal plane is defined by the N2O2 atoms of the tetra­dentate Schiff base ligand and the O atom of the dimethyl sulfoxide mol­ecule. In the crystal, centrosymmetric aggregates are formed via pairs of C—H⋯O inter­actions. The azomethine C=N atoms and ethyl­thiolyl group are disordered over two orientations in a 0.828 (3):0.172 (3) ratio

{4-Bromo-2-[(2-{(ethyl­sulfan­yl)[(2-oxidobenzyl­idene-κO)amino-κN]methylidene}hydrazinyl­idene-κN 1)meth­yl]phenolato-κO}(butan-2-ol-κO)dioxidouranium(VI)

The UVI cation in the title complex, [U(C17H14BrN3O2S)O2(C4H10O)], exists within a distorted penta­gonal–bipyramidal geometry, where the oxide atoms occupy the axial positions [O—U—O = 179.8 (3)°] and the penta­gonal plane is defined by the N2O2 atoms of the tetra­dentate Schiff base ligand and the O atom of the 2-butanol mol­ecule. In the crystal, centrosymmetric aggregates are formed via pairs of hy­droxy–phenolate O—H⋯O hydrogen bonds. The azomethine C=N atoms, the ethyl­thiolyl group, the 2-butanol mol­ecule and Br atom are disordered over two positions in a 0.627 (3):0.373 (3) ratio

Folding of truncated granulin peptides

Granulins are a family of unique protein growth factors which are found in a range of species and have several bioactivities that include cell proliferation and wound healing. They typically contain six disulfide bonds, but the sequences, structures and bioactivities vary significantly. We have previously shown that an N-terminally truncated version of a granulin from the human liver fluke, Opisthorchis viverrini, can fold independently into a “mini-granulin” structure and has potent wound healing properties in vivo. The incorporation of a non-native third disulfide bond, with respect to the full-length granulin module, was critical for the formation of regular secondary structure in the liver fluke derived peptide. By contrast, this third disulfide bond is not required for a carp granulin-1 truncated peptide to fold independently. This distinction led us to explore granulins from the zebrafish model organism. Here we show that the mini-granulin fold occurs in a naturally occurring paragranulin (half-domain) from zebrafish, and is also present in a truncated form of a full-length zebrafish granulin, suggesting this structure might be a common property in either naturally occurring or engineered N-terminally truncated granulins and the carp granulin-1 folding is an anomaly. The in vitro folding yield is significantly higher in the naturally occurring paragranulin, but only the truncated zebrafish granulin peptide promoted the proliferation of fibroblasts consistent with a growth factor function, and therefore the function of the paragranulin remains unknown. These findings provide insight into the folding and evolution of granulin domains and might be useful in the elucidation of the structural features important for bioactivity to aid the design of more potent and stable analogues for the development of novel wound healing agents

Bis[μ-4-(2-oxidobenzyl­idene)thio­semi­carbazidato-κ4 S,N 1,O:O]bis­[(pyridine-κN)zinc]

In the title compound, [Zn2(C8H7N3OS)2(C5H5N)2], the Zn2O2 ring has a flattened roof shape, with the roof angle equal to 10.10 (6)°. The thio­semicarbazones act as tridentate ligands to one ZnII atom, with the O atoms additionally in bridging positions to the second ZnII atom. Both ZnII atoms are five-coordinated; the coordination polyhedra are close to square pyramids, with the pyridine N atoms at apical positions. Two inter­molecular N—H⋯N and one relatively weak N—H⋯S hydrogen bond, together with C—H⋯S weak inter­actions, connect the mol­ecules into a three-dimensional network