Scheme dependence of instanton counting in ALE spaces

There have been two distinct schemes studied in the literature for instanton counting in A_(p−1) asymptotically locally Euclidean (ALE) spaces. We point out that the two schemes — namely the counting of orbifolded instantons and instanton counting in the resolved space — lead in general to different results for partition functions. We illustrate this observation in the case of N=2 U(N) gauge theory with 2N flavors on the A_(p−1) ALE space. We propose simple relations between the instanton partition functions given by the two schemes and test them by explicit calculations

N=4 Instanton Calculus in Omega and R-R Backgrounds

We study the instanton calculus for N=4 super Yang-Mills theory in ten-dimensional Omega-background with the R-symmetry Wilson line gauge field. From the ADHM construction of instantons in the background, we obtain the deformed instanton effective action. For a certain case we get the effective action of N=2^* theory in the Omega-background. We also study the low-energy effective D(-1)-brane action for the D3/D(-1)-brane system in the R-R 3-form field strength backgrounds and find that the action agrees with the instanton effective action in the Omega-background.Comment: 28 page

教育予算と政治的要因 : 京都府の教育予算と知事選挙

本研究の目的は, 教育予算の策定にあたって, 知事選挙における優位性の確保のための政治的影響を摘出することである｡その研究理由としては, 知事選挙の候補者が教育費を重要視すれば, ひいては, 府民の教育の行政サービスに繋がるものであり, 知事部局理事者側にとっても, 一定の配慮もありうると考えられるからである｡研究方法については, 当初予算や教育費の経年変化の動向や, 知事選挙の状況などから, 特異な現象を摘出し, 検証しながら, 政治的要因を把握しようとするものである｡その研究結果は, 分析領域内において, 1970 (昭和45) 年度, 1974 (昭和49) 年度, 1978 (昭和53) 年度,1982 (昭和57) 年度, 1994 (平成６) 年度の教育費予算の算定については, 知事選挙における優位性の確保のため, 十分配慮したものと思われる｡つまり知事選挙の優位性の確保という政治的要因が働いたといえるだろう｡更に, 本テーマについて, 研究を継続し, 結果についても一層多面的な視角から精査し, 次回の筆者の論文に繋げる予定である｡The purpose of this research is to extract influence for the political factor to which the authorities have influence into the decision process of an educational budget for reservation of the predominancy in a governor’s election. It is because it is thought that consideration called operation of an education expense may have the reason for reservation of the predominancy in a governor’s election, and the operation also has the merit of being connected with the administrative services of education of the citizen of prefecture if the nominee of a governor’s election thinks an education expense as important.It is grasping a political factor, extracting and verifying a nontypical phenomenon from aging of an initial budget and an education expense, a governor’s election situation, etc. about a method of research.Considering research findings, [in an analysis domain], it is surmised that the authorities did compliment influence in the following fiscal years. We can point out about the education expense of 1970 (Showa 45) fiscal years, 1974 (Showa 49) fiscal years, 1978 (Showa 53) fiscal years, 1982 (Showa 57) fiscal years, and 1994 (Heisei 6) fiscal years

Crystalline Silicate Feature of the Vega-like star HD145263

We have observed the 8-13 $\mu$m spectrum (R$\sim$250) of the Vega-like star candidate HD145263 using Subaru/COMICS. The spectrum of HD145263 shows the broad trapezoidal silicate feature with the shoulders at 9.3 $\mu$m and 11.44 $\mu$m, indicating the presence of crystalline silicate grains. This detection implies that crystalline silicate may also be commonly present around Vega-like stars. The 11.44 $\mu$m feature is slightly shifted to a longer wavelength compared to the usual 11.2-3 $\mu$m crystalline forsterite feature detected toward Herbig Ae/Be stars and T Tauri stars. Although the peak shift due to the effects of the grain size can not be ruled out, we suggest that Fe-bearing crystalline olivine explains the observed peak wavelength fairly well. Fe-bearing silicates are commonly found in meteorites and most interplanetary dust particles, which originate from planetesimal-like asteroids. According to studies of meteorites, Fe-bearing silicate must have been formed in asteroidal planetesimals, supporting the scenario that dust grains around Vega-like stars are of planetesimal origin, if the observed 11.44 $\mu$m peak is due to Fe-bearing silicates.Comment: accepted for Publication in ApJ

N=2 Instanton Effective Action in Omega-background and D3/D(-1)-brane System in R-R Background

We study the relation between the ADHM construction of instantons in the Omega-background and the fractional D3/D(-1)-branes at the orbifold singularity of C \times C^2/Z_2 in Ramond-Ramond (R-R) 3-form field strength background. We calculate disk amplitudes of open strings connecting the D3/D(-1)-branes in certain R-R background to obtain the D(-1)-brane effective action deformed by the R-R background. We show that the deformed D(-1)-brane effective action agrees with the instanton effective action in the Omega-background.Comment: 35 pages, no figures, references adde

Identification of hepta-histidine as a candidate drug for Huntington's disease by in silico-in vitro- in vivo-integrated screens of chemical libraries.

We identified drug seeds for treating Huntington's disease (HD) by combining in vitro single molecule fluorescence spectroscopy, in silico molecular docking simulations, and in vivo fly and mouse HD models to screen for inhibitors of abnormal interactions between mutant Htt and physiological Ku70, an essential DNA damage repair protein in neurons whose function is known to be impaired by mutant Htt. From 19,468 and 3,010,321 chemicals in actual and virtual libraries, fifty-six chemicals were selected from combined in vitro-in silico screens; six of these were further confirmed to have an in vivo effect on lifespan in a fly HD model, and two chemicals exerted an in vivo effect on the lifespan, body weight and motor function in a mouse HD model. Two oligopeptides, hepta-histidine (7H) and Angiotensin III, rescued the morphological abnormalities of primary neurons differentiated from iPS cells of human HD patients. For these selected drug seeds, we proposed a possible common structure. Unexpectedly, the selected chemicals enhanced rather than inhibited Htt aggregation, as indicated by dynamic light scattering analysis. Taken together, these integrated screens revealed a new pathway for the molecular targeted therapy of HD

Kaempulchraols A−H, diterpenoids from the rhizomes of Kaempferia pulchra collected in Myanmar

Eight new diterpenoids, kaempulchraols A−H (1−8), along with five known analogues were isolated from the CHCl3 soluble extract of rhizomes of Kaempferia pulchra of Myanmar. The structures of these compounds were elucidated using extensive spectroscopic techniques including X-ray diffraction analysis. All the isolates were tested for their antiproliferative activity against a panel of five human cancer cell lines (A549, human lung cancer; HeLa, human cervix cancer; PANC-1 and PSN-1, human pancreatic cancer, MDA-MB-231, human breast cancer) and TIG-3, normal human primary fibroblast cells. Kaempulchraol F (6) exhibited weak activity against human pancreatic PSN-1 cell line with an IC50 value of 12.3 μM

Numerical Study on Acoustic Oscillations of 2D and 3D Flue Organ Pipe Like Instruments with Compressible LES

Acoustic oscillations of flue instruments are investigated numerically using compressible Large Eddy Simulation (LES). Investigating 2D and 3D models of flue instruments, we reproduce acoustic oscillations excited in the resonators as well as an important characteristic feature of flue instruments – the relation between the acoustic frequency and the jet velocity described by the semi-empirical theory developed by Cremer & Ising, Coltman and Fletcher et al. based on experimental results. Both 2D and 3D models exhibit almost the same oscillation frequency for a given jet velocity, but the acoustic oscillation as well as the jet motion is more stable in the 3D model than in the 2D model, due to less stability in 3D fluid of the rolled up eddies created by the collision of the jet with the edge, which largely disturb the jet motion and acoustic field in the 2D model. We also investigate the ratio of the amplitude of the acoustic flow through the mouth opening to the jet velocity, comparing with the experimental results and semi-empirical theory given by Hirschberg et al.