Optimization of Italian CMS Computing Centers via MIUR funded Research Projects

In 2012, 14 Italian Institutions participating LHC Experiments (10 in CMS) have won a grant from the Italian Ministry of Research (MIUR), to optimize Analysis activities and in general the Tier2/Tier3 infrastructure. A large range of activities is actively carried on: they cover data distribution over WAN, dynamic provisioning for both scheduled and interactive processing, design and development of tools for distributed data analysis, and tests on the porting of CMS software stack to new highly performing / low power architectures

Direct dating confirms the presence of otter and badger in early Holocene Ireland

The origin of Ireland’s fauna is an unresolved issue in the history of the island. Although researchers once considered Ireland’s mammals to have spread to Ireland during the early postglacial from 11,700 cal BP, research has increasingly suggested humans translocated many of these species to Ireland. However, due to sparse evidence, the origin of Ireland’s purported native mustelid species remains unanswered. In this study, we shed light on the history of otter and badger in Ireland by directly dating suspected early examples of these species from Derragh, Co. Longford, a late Mesolithic campsite. The results demonstrate that both of these species have been present in Ireland for at least 7000–8000 years. It is not clear if they represent self-colonisers or Mesolithic anthropogenic translocations. Although these finds do not rule out local extinction and later reintroduction, they show that we can no longer assume they are solely late Holocene introductions. © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group

Improvements of LHC data analysis techniques at Italian WLCG sites. Case-study of the transfer of this technology to other research areas

In 2012, 14 Italian institutions participating in LHC Experiments won a grant from the Italian Ministry of Research (MIUR), with the aim of optimising analysis activities, and in general the Tier2/Tier3 infrastructure. We report on the activities being researched upon, on the considerable improvement in the ease of access to resources by physicists, also those with no specific computing interests. We focused on items like distributed storage federations, access to batch-like facilities, provisioning of user interfaces on demand and cloud systems. R&D on next-generation databases, distributed analysis interfaces, and new computing architectures was also carried on. The project, ending in the first months of 2016, will produce a white paper with recommendations on best practices for data-analysis support by computing centers

COGNITIVE THEORY OF CATEGORIZATION, AS EXEMPLIFIED ON JAPANESE MATERIAL

Nakon uvodnog utvrđivanja teorijske razlike između tradicionalnog aristotelovskog i suvremenog kognitivnog poimanja procesa ljudske kategorizacije, te navođenja prednosti kognitivnog pristupa, autor u ovome radu na primjerima iz japanskoga jezika oprimjeruje mentalne procese prisutne u oblikovanju konceptualnih kategorija koje su preslikane na jezični materijal. Na primjerima se japanskih brojača objašnjavaju procesi koji uključuju konceptualnu metaforu i metonimiju, konvencionalne mentalne slike, transformaciju slike u shemu (shematizacija), višestruko temeljenu motivaciju te pojavu lančanog vezivanja (značenjski lanci). Također se primjerom konceptualne kategorije ja u japanskome jeziku prikazuje sposobnost utjecaja društva i kulture da nametnu značenjski okvir unutar kojega će se određena kategorija upotrebljavati.After an introduction to theoretical distinctions between traditional Aristotelian and contemporary cognitive approach to the process of human categorization, and a demonstration of the advantages of the cognitive approach, the paper goes on to discuss Japanese data which exemplify mental processes underlying the formation of conceptual categories and their mapping onto linguistic structures. Japanese classifiers are discussed in the context of cognitive phenomena such as conceptual metaphor and metonymy, conventional mental images, imageschema transformation, multiple motivation, and the phenomenon of chaining structures. The final section discusses the conceptual category self in Japanese, specifically the ability of society and culture to impose a meaning frame within which a given category will be used

Detecting hidden diets and disease: Zoonotic parasites and fish consumption in Mesolithic Ireland

Archaeoparasitology is increasingly being used as a tool in archaeological research to investigate relationships between past humans, environments, diets and disease. It can be particularly useful in contexts where parasite eggs preserve, but human and faunal remains do not, including in the identification of disease and/or dietary items otherwise absent from the local archaeological record. We analyzed soil samples from the Late Mesolithic layers of the lake island site of Derragh in County Longford, Ireland. All samples were positive for the presence of Diphyllobothrium sp., an intestinal fish tapeworm that infects humans, causing diphyllobothriasis. Though fish are thought to be a staple food in Mesolithic Ireland, evidence for fishing and subsistence from this period is extremely fragmentary. Similarly, there is little available evidence for disease, primarily due to the lack of human remains. This finding represents the earliest known presence of human-derived parasites in Ireland, the earliest known finding of Diphyllobothrium sp. in Europe and the only finding of the tapeworm from hunter-gatherer contexts. It suggests parasitic infections, particularly those resulting from undercooked food, may be more common in ancient hunter-gatherer populations than previously suspected. The presence of these zoonotic parasites at hunter-gatherer sites can provide important insight into local environments, health and disease, and culinary practices. In locations like Mesolithic Ireland, the presence of parasites may assist in the identification of subsistence activities, such as fishing, and specific prey

Palaeoproteomic evidence identifies archaic hominins associated with the Châtelperronian at the Grotte du Renne

In Western Europe, the Middle to Upper Paleolithic transition is associated with the disappearance of Neandertals and the spread of anatomically modern humans (AMHs). Current chronological, behavioral, and biological models of this transitional period hinge on the Châtelperronian technocomplex. At the site of the Grotte du Renne, Arcy-sur-Cure, morphological Neandertal specimens are not directly dated but are contextually associated with the Châtelperronian, which contains bone points and beads. The association between Neandertals and this “transitional” assemblage has been controversial because of the lack either of a direct hominin radiocarbon date or of molecular confirmation of the Neandertal affiliation. Here we provide further evidence for a Neandertal–Châtelperronian association at the Grotte du Renne through biomolecular and chronological analysis. We identified 28 additional hominin specimens through zooarchaeology by mass spectrometry (ZooMS) screening of morphologically uninformative bone specimens from Châtelperronian layers at the Grotte du Renne. Next, we obtain an ancient hominin bone proteome through liquid chromatography-MS/MS analysis and error-tolerant amino acid sequence analysis. Analysis of this palaeoproteome allows us to provide phylogenetic and physiological information on these ancient hominin specimens. We distinguish Late Pleistocene clades within the genus Homo based on ancient protein evidence through the identification of an archaic-derived amino acid sequence for the collagen type X, alpha-1 (COL10α1) protein. We support this by obtaining ancient mtDNA sequences, which indicate a Neandertal ancestry for these specimens. Direct accelerator mass spectometry radiocarbon dating and Bayesian modeling confirm that the hominin specimens date to the Châtelperronian at the Grotte du Renne.Freely available online through the PNAS open access option. Open access articles are published under a nonexclusive License to Publish and distributed under a Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND) license.NHM Repositor

The Middle-to-Upper Paleolithic transition occupations from Cova Foradada (Calafell, NE Iberia)

The Middle-to-Upper Paleolithic transition in Europe covers the last millennia of Neanderthal life together with the appearance and expansion of Modern Human populations. Culturally, it is defined by the Late Middle Paleolithic succession, and by Early Upper Paleolithic complexes like the Châtelperronian (southwestern Europe), the Protoaurignacian, and the Early Aurignacian. Up to now, the southern boundary for the transition has been established as being situated between France and Iberia, in the Cantabrian façade and Pyrenees. According to this, the central and southern territories of Iberia are claimed to have been the refuge of the last Neanderthals for some additional millennia after they were replaced by anatomically Modern Humans on the rest of the continent. In this paper, we present the Middle-to-Upper Paleolithic transition sequence from Cova Foradada (Tarragona), a cave on the Catalan Mediterranean coastline. Archaeological research has documented a stratigraphic sequence containing a succession of very short-term occupations pertaining to the Châtelperronian, Early Aurignacian, and Gravettian. Cova Foradada therefore represents the southernmost Châtelperronian-Early Aurignacian sequence ever documented in Europe, significantly enlarging the territorial distribution of both cultures and providing an important geographical and chronological reference for understanding Neanderthal disappearance and the complete expansion of anatomically Modern Humans

Aggressive therapy in patients with early arthritis results in similar outcome compared with conventional care: the STREAM randomized trial

Objective. To compare the effects of aggressive tight control therapy and conventional care on radiographic progression and disease activity in patients with early mild inflammatory arthritis

Ancient genomes reveal structural shifts after the arrival of Steppe-related ancestry in the Italian Peninsula

Across Europe, the genetics of the Chalcolithic/Bronze Age transition is increasingly characterized in terms of an influx of Steppe-related ancestry. The effect of this major shift on the genetic structure of populations in the Italian Peninsula remains underexplored. Here, genome-wide shotgun data for 22 individuals from commingled cave and single burials in Northeastern and Central Italy dated between 3200 and 1500 BCE provide the first genomic characterization of Bronze Age individuals (n = 8; 0.001–1.2× coverage) from the central Italian Peninsula, filling a gap in the literature between 1950 and 1500 BCE. Our study confirms a diversity of ancestry components during the Chalcolithic and the arrival of Steppe-related ancestry in the central Italian Peninsula as early as 1600 BCE, with this ancestry component increasing through time. We detect close patrilineal kinship in the burial patterns of Chalcolithic commingled cave burials and a shift away from this in the Bronze Age (2200–900 BCE) along with lowered runs of homozygosity, which may reflect larger changes in population structure. Finally, we find no evidence that the arrival of Steppe-related ancestry in Central Italy directly led to changes in frequency of 115 phenotypes present in the dataset, rather that the post-Roman Imperial period had a stronger influence, particularly on the frequency of variants associated with protection against Hansen's disease (leprosy). Our study provides a closer look at local dynamics of demography and phenotypic shifts as they occurred as part of a broader phenomenon of widespread admixture during the Chalcolithic/Bronze Age transition