Wall-Enhanced Convection in Vibrofluidized Granular Systems

An event-driven molecular dynamics simulation of inelastic hard spheres contained in a cylinder and subject to strong vibration reproduces accurately experimental results[1] for a system of vibrofluidized glass beads. In particular, we are able to obtain the velocity field and the density and temperature profiles observed experimentally. In addition, we show that the appearance of convection rolls is strongly influenced by the value of the sidewall-particle restitution coefficient. Suggestions for observing more complex convection patterns are proposed.Comment: 4 pages, 6 figure

From Car Parking to Protein Adsorption: An Overview of Sequential Adsorption Processes

The adsorption or adhesion of large particles (proteins, colloids, cells, >...) at the liquid-solid interface plays an important role in many diverse applications. Despite the apparent complexity of the process, two features are particularly important: 1) the adsorption is often irreversible on experimental time scales and 2) the adsorption rate is limited by geometric blockage from previously adsorbed particles. A coarse-grained description that encompasses these two properties is provided by sequential adsorption models whose simplest example is the random sequential adsorption (RSA) process. In this article, we review the theoretical formalism and tools that allow the systematic study of kinetic and structural aspects of these sequential adsorption models. We also show how the reference RSA model may be generalized to account for a variety of experimental features including particle anisotropy, polydispersity, bulk diffusive transport, gravitational effects, surface-induced conformational and orientational change, desorption, and multilayer formation. In all cases, the significant theoretical results are presented and their accuracy (compared to computer simulation) and applicability (compared to experiment) are discussed.Comment: 51 pages, 18 Figures, to appear in a special volume entitled "Adhesion of Submicron Particles on Solid Surfaces" of Colloids and Surfaces A, guest-edited by V. Privman.to appear in a special volume entitle

Aging and response properties in the parking-lot model

An adsorption-desorption (or parking-lot) model can reproduce qualitatively the densification kinetics and other features of a weakly vibrated granular material. Here we study the the two-time correlation and response functions of the model and demonstrate that their behavior is consistent with recently observed memory effects in granular materials. Although the densification kinetics and hysteresis are robust properties, we show that the aging behavior of the adsorption-desorption model is different from other models of granular compaction. We propose an experimental test to distinguish the possible aging behaviors.Comment: 9 pages, 7 figures, to appear in Eur. Phys. Jour.

Generalized model of blockage in particulate flow limited by channel carrying capacity

We investigate stochastic models of particles entering a channel with a random time distribution. When the number of particles present in the channel exceeds a critical value $N$, a blockage occurs and the particle flux is definitively interrupted. By introducing an integral representation of the $n$ particle survival probabilities, we obtain exact expressions for the survival probability, the distribution of the number of particles that pass before failure, the instantaneous flux of exiting particle and their time correlation. We generalize previous results for $N=2$ to an arbitrary distribution of entry times and obtain new, exact solutions for $N=3$ for a Poisson distribution and partial results for $N\ge 4$.Comment: 13 pages, 9 figure

A simple method for estimating minimum autorotative descent rate of single rotor helicopters

Flight test results of minimum autorotative descent rate are compared with calculations based on the minimum power required for steady level flight. Empirical correction factors are derived that account for differences in energy dissipation between these two flight conditions. A method is also presented for estimating the minimum power coefficient for level flight for any helicopter for use in the empirical estimation procedure of autorotative descent rate

DNMTs are required for delayed genome instability caused by radiation

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited - Copyright @ 2012 Landes Bioscience.The ability of ionizing radiation to initiate genomic instability has been harnessed in the clinic where the localized delivery of controlled doses of radiation is used to induce cell death in tumor cells. Though very effective as a therapy, tumor relapse can occur in vivo and its appearance has been attributed to the radio-resistance of cells with stem cell-like features. The molecular mechanisms underlying these phenomena are unclear but there is evidence suggesting an inverse correlation between radiation-induced genomic instability and global hypomethylation. To further investigate the relationship between DNA hypomethylation, radiosensitivity and genomic stability in stem-like cells we have studied mouse embryonic stem cells containing differing levels of DNA methylation due to the presence or absence of DNA methyltransferases. Unexpectedly, we found that global levels of methylation do not determine radiosensitivity. In particular, radiation-induced delayed genomic instability was observed at the Hprt gene locus only in wild-type cells. Furthermore, absence of Dnmt1 resulted in a 10-fold increase in de novo Hprt mutation rate, which was unaltered by radiation. Our data indicate that functional DNMTs are required for radiation-induced genomic instability, and that individual DNMTs play distinct roles in genome stability. We propose that DNMTS may contribute to the acquirement of radio-resistance in stem-like cells.This study is funded by NOTE, BBSRC and the Royal Society Dorothy Hodgkin Research Fellowship