8,396 research outputs found
A phase 1 dose-escalation and expansion study of binimetinib (MEK162), a potent and selective oral MEK1/2 inhibitor
Probabilistic error estimation for non-intrusive reduced models learned from data of systems governed by linear parabolic partial differential equations
This work derives a residual-based a posteriori error estimator for reduced
models learned with non-intrusive model reduction from data of high-dimensional
systems governed by linear parabolic partial differential equations with
control inputs. It is shown that quantities that are necessary for the error
estimator can be either obtained exactly as the solutions of least-squares
problems in a non-intrusive way from data such as initial conditions, control
inputs, and high-dimensional solution trajectories or bounded in a
probabilistic sense. The computational procedure follows an offline/online
decomposition. In the offline (training) phase, the high-dimensional system is
judiciously solved in a black-box fashion to generate data and to set up the
error estimator. In the online phase, the estimator is used to bound the error
of the reduced-model predictions for new initial conditions and new control
inputs without recourse to the high-dimensional system. Numerical results
demonstrate the workflow of the proposed approach from data to reduced models
to certified predictions
GMC Collisions As Triggers of Star Formation. IV. The Role of Ambipolar Diffusion
We investigate the role of ambipolar diffusion (AD) in collisions between
magnetized giant molecular clouds (GMCs), which may be an important mechanism
for triggering star cluster formation. Three dimensional simulations of GMC
collisions are performed using a version of the Enzo magnetohydrodynamics code
that has been extended to include AD. The resistivities are calculated using
the 31-species chemical model of Wu et al. (2015). We find that in the
weak-field, case, AD has only a modest effect on the
dynamical evolution during the collision. However, for the stronger-field,
case involving near-critical clouds, AD results in formation
of dense cores in regions where collapse is otherwise inhibited. The overall
efficiency of formation of cores with in
these simulations is increases from about 0.2% to 2% once AD is included,
comparable to observed values in star-forming GMCs. The gas around these cores
typically has relatively slow infall at speeds that are a modest fraction of
the free-fall speed.Comment: 15 pages, 15 figures, Accepted to Ap
An average-case depth hierarchy theorem for Boolean circuits
We prove an average-case depth hierarchy theorem for Boolean circuits over
the standard basis of , , and gates.
Our hierarchy theorem says that for every , there is an explicit
-variable Boolean function , computed by a linear-size depth- formula,
which is such that any depth- circuit that agrees with on fraction of all inputs must have size This
answers an open question posed by H{\aa}stad in his Ph.D. thesis.
Our average-case depth hierarchy theorem implies that the polynomial
hierarchy is infinite relative to a random oracle with probability 1,
confirming a conjecture of H{\aa}stad, Cai, and Babai. We also use our result
to show that there is no "approximate converse" to the results of Linial,
Mansour, Nisan and Boppana on the total influence of small-depth circuits, thus
answering a question posed by O'Donnell, Kalai, and Hatami.
A key ingredient in our proof is a notion of \emph{random projections} which
generalize random restrictions
Where and Who? Automatic Semantic-Aware Person Composition
Image compositing is a method used to generate realistic yet fake imagery by
inserting contents from one image to another. Previous work in compositing has
focused on improving appearance compatibility of a user selected foreground
segment and a background image (i.e. color and illumination consistency). In
this work, we instead develop a fully automated compositing model that
additionally learns to select and transform compatible foreground segments from
a large collection given only an input image background. To simplify the task,
we restrict our problem by focusing on human instance composition, because
human segments exhibit strong correlations with their background and because of
the availability of large annotated data. We develop a novel branching
Convolutional Neural Network (CNN) that jointly predicts candidate person
locations given a background image. We then use pre-trained deep feature
representations to retrieve person instances from a large segment database.
Experimental results show that our model can generate composite images that
look visually convincing. We also develop a user interface to demonstrate the
potential application of our method.Comment: 10 pages, 9 figure
GMC Collisions As Triggers of Star Formation. IV. The Role of Ambipolar Diffusion
We investigate the role of ambipolar diffusion (AD) in collisions between
magnetized giant molecular clouds (GMCs), which may be an important mechanism
for triggering star cluster formation. Three dimensional simulations of GMC
collisions are performed using a version of the Enzo magnetohydrodynamics code
that has been extended to include AD. The resistivities are calculated using
the 31-species chemical model of Wu et al. (2015). We find that in the
weak-field, case, AD has only a modest effect on the
dynamical evolution during the collision. However, for the stronger-field,
case involving near-critical clouds, AD results in formation
of dense cores in regions where collapse is otherwise inhibited. The overall
efficiency of formation of cores with in
these simulations is increases from about 0.2% to 2% once AD is included,
comparable to observed values in star-forming GMCs. The gas around these cores
typically has relatively slow infall at speeds that are a modest fraction of
the free-fall speed.Comment: 15 pages, 15 figures, Accepted to Ap
The Interstellar Medium and Star Formation of Galactic Disks. I. ISM and GMC properties with Diffuse FUV and Cosmic Ray Backgrounds
We present a series of adaptive mesh refinement (AMR) hydrodynamic
simulations of flat rotation curve galactic gas disks with a detailed treatment
of the interstellar medium (ISM) physics of the atomic to molecular phase
transition under the influence of diffuse FUV radiation fields and cosmic ray
backgrounds. We explore the effects of different FUV intensities, including a
model with a radial gradient designed to mimic the Milky Way. The effects of
cosmic rays, including radial gradients in their heating and ionization rates,
are also explored. The final simulations in this series achieve pc
resolution across the kpc global disk diameter, with heating and
cooling followed down to temperatures of K. The disks are evolved for
Myr, which is enough time for the ISM to achieve a quasi-statistical
equilibrium. In particular, the mass fraction of molecular gas stabilizes by
200 Myr. Additional global ISM properties are analysed. Giant molecular
clouds (GMCs) are also identified and the statistical properties of their
populations examined. GMCs are tracked as the disks evolve. GMC collisions,
which may be a means of triggering star cluster formation, are counted and the
rates compared with analytic models. Relatively frequent GMC collision rates
are seen in these simulations and their implications for understanding GMC
properties, including the driving of internal turbulence, are discussed.Comment: Accepted by PASJ (cloud-cloud collision special issue
Computational Modelling of Wing Downwash Profile with Reynolds-Averaged and Delayed Detached-Eddy Simulations
This paper describes the computational model to predict downwash for a conventional
fixed wing configuration at flight scales (ReMAC = 2.26 × 107
). The lack of resolution in the
downwash wake region resulted in an over-dissipation of the turbulent behaviour of airflow
in the wing’s wake. This artificially inflates the effectiveness of the horizontal stabilizer where
an over-prediction of pitch stiffness was observed. To resolve this over-dissipation, both the
Reynolds-Averaged and Delayed Detached-Eddy Simulation methodology were adopted to
accurately capture the downwash profile leaving the wing. Comparisons between the
estimation of wall shear stresses and viscous wall unit against a ‘first-cut’ simulation are made
and discussed. Fundamental features of the downwash profile including the spatial and
temporal scales used for the mesh are also presented and detailed in this paper
Ensemble candidate classification for the LOTAAS pulsar survey
One of the biggest challenges arising from modern large-scale pulsar surveys is the number of candidates generated. Here, we implemented several improvements to the machine learning (ML) classifier previously used by the LOFAR Tied-Array All-Sky Survey (LOTAAS) to look for new pulsars via filtering the candidates obtained during periodicity searches. To assist the ML algorithm, we have introduced new features which capture the frequency and time evolution of the signal and improved the signal-to-noise calculation accounting for broad profiles. We enhanced the ML classifier by including a third class characterizing RFI instances, allowing candidates arising from RFI to be isolated, reducing the false positive return rate. We also introduced a new training data set used by the ML algorithm that includes a large sample of pulsars misclassified by the previous classifier. Lastly, we developed an ensemble classifier comprised of five different Decision Trees. Taken together these updates improve the pulsar recall rate by 2.5 per cent, while also improving the ability to identify pulsars with wide pulse profiles, often misclassified by the previous classifier. The new ensemble classifier is also able to reduce the percentage of false positive candidates identified from each LOTAAS pointing from 2.5 per cent (∼500 candidates) to 1.1 per cent (∼220 candidates)
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