Cost-effectiveness of financial incentives for smoking cessation in pregnancy

No abstract available

Used infant mattresses and sudden infant death syndrome in Scotland: case-control study

<P>OBJECTIVE: To examine the proposition that a used infant mattress is associated with an increased risk of sudden infant death syndrome. DESIGN: Case-control study. SETTING: Scotland (population 5.1 million, with about 53 000 births a year).</P> <P>PARTICIPANTS: 131 infants who died of sudden infant death syndrome between 1 January 1996 and 31 May 2000 and 278 age, season, and obstetric unit matched control infants.</P> <P>MAIN OUTCOME MEASURES: Routine use of an infant mattress previously used by another child and place of last sleep.</P> <P>RESULTS: Routine use of an infant mattress previously used by another child was significantly associated with an increased risk of sudden infant death syndrome (multivariate odds ratio 3.07, 95% confidence interval 1.51 to 6.22). Use of a used infant mattress for last sleep was also associated with increased risk (6.10, 2.31 to 16.12). The association was significantly stronger if the mattress was from another home (4.78, 2.08 to 11.0) than if it was from the same home (1.64, 0.64 to 4.2).</P> <P>CONCLUSION: A valid significant association exists between use of a used infant mattress and an increased risk of sudden infant death syndrome, particularly if the mattress is from another home. Insufficient evidence is available to judge whether this relation is cause and effect.</P&gt

Observations of Detailed Structure in the Solar Wind at 1 AU with STEREO/HI-2

Heliospheric imagers offer the promise of remote sensing of large-scale structures present in the solar wind. The STEREO/HI-2 imagers, in particular, offer high resolution, very low noise observations of the inner heliosphere but have not yet been exploited to their full potential. This is in part because the signal of interest, Thomson scattered sunlight from free electrons, is ~1000 times fainter than the background visual field in the images, making background subtraction challenging. We have developed a procedure for separating the Thomson-scattered signal from the other background/foreground sources in the HI-2 data. Using only the Level 1 data from STEREO/HI-2, we are able to generate calibrated imaging data of the solar wind with sensitivity of a few times 1e-17 Bsun, compared to the background signal of a few times 1e-13 Bsun. These images reveal detailed spatial structure in CMEs and the solar wind at projected solar distances in excess of 1 AU, at the instrumental motion-blur resolution limit of 1-3 degree. CME features visible in the newly reprocessed data from December 2008 include leading-edge pileup, interior voids, filamentary structure, and rear cusps. "Quiet" solar wind features include V shaped structure centered on the heliospheric current sheet, plasmoids, and "puffs" that correspond to the density fluctuations observed in-situ. We compare many of these structures with in-situ features detected near 1 AU. The reprocessed data demonstrate that it is possible to perform detailed structural analyses of heliospheric features with visible light imagery, at distances from the Sun of at least 1 AU.Comment: Accepted by Astrophysical Journa

The English Channel: Contamination status of its transitional and coastal waters.

The chemical contamination (organic compounds, metals, radionuclides, microplastics, nutrients) of English Channel waters has been reviewed, focussing on the sources, concentrations and impacts. River loads were only reliable for Pb, whereas atmospheric loads appeared robust for Cd, Pb, Hg, PCB-153 and γ-HCH. Temporal trends in atmospheric inputs were decreasing. Contaminant concentrations in biota were relatively constant or decreasing, but not for Cd, Hg and HBCDD, and deleterious impacts on fish and copepods were reported. However, data on ecotoxicological effects were generally sparse for legacy and emerging contaminants. Intercomparison of activity concentrations of artificial radionuclides in sediments and biota on both Channel coasts was hindered by differences in methodological approaches. Riverine phosphate loads decreased with time, while nitrate loads remained uniform. Increased biomass of algae, attributable to terrestrial inputs of nutrients, has affected benthic production and shellfisheries. A strategic approach to the identification of contaminant impacts on marine biota is recommended

Reconstitution of recombination-associated DNA synthesis with human proteins.

The repair of DNA breaks by homologous recombination is a high-fidelity process, necessary for the maintenance of genome integrity. Thus, DNA synthesis associated with recombinational repair must be largely error-free. In this report, we show that human DNA polymerase delta (δ) is capable of robust DNA synthesis at RAD51-mediated recombination intermediates dependent on the processivity clamp PCNA. Translesion synthesis polymerase eta (η) also extends these substrates, albeit far less processively. The single-stranded DNA binding protein RPA facilitates recombination-mediated DNA synthesis by increasing the efficiency of primer utilization, preventing polymerase stalling at specific sequence contexts, and overcoming polymerase stalling caused by topological constraint allowing the transition to a migrating D-loop. Our results support a model whereby the high-fidelity replicative DNA polymerase δ performs recombination-associated DNA synthesis, with translesion synthesis polymerases providing a supportive role as in normal replication

The 2011 UK meteotsunami: a study in science

When reports started coming in that southern Britain had been hit by a tsunami, they were hard to believe. But it turns out there really had been one – just not the kind we usually hear about. Dave Tappin describes the scientific detective work that uncovered the truth

Shetlands Islands field trip May 2014 : summary of results

This report provides a record of a field excursion to the Shetland Islands in May 2014 to investigate sediments deposited from tsunamis generated from submarine landslides mainly located off the coast of Norway. The research was funded under a NERC Consortium Grant for a project entitled ‘Will climate change in the Arctic increase the landslide-tsunami risk to the UK?’ It was part of Work Block 2 (WB2): ‘What is the timing of tsunami deposits on the UK coastline, and how is it related to the age of major Arctic slides’? The best known and most studied tsunami from the Norwegian submarine landslides is the Storegga event dated at 8,200BP. Sediments deposited from this tsunami are commonly found along the west coast of Norway, east coast of mainland Scotland, and also on the Shetland and Faeroe islands. However, there are other landslides off of Norway for which no associated tsunami has been identified, which poses the question as to whether these events did not generate a tsunami or whether the evidence for a tsunami has not yet been found. Although evidence for seabed slumping off Norway was first discovered in the 1950’s (Holtedahl, 1955, 1971) and the scale and morphology of a massive submarine landslide, subsequently termed Storegga, mapped in the 1970’s (Bugge, 1983), it was not until 1985 that an associated tsunami was first proposed (Svendsen, 1985). The first supporting sedimentary evidence of the tsunami was first identified on mainland Scotland in 1988 (Dawson et al., 1988) then, subsequently, similar sediments were identified on the Shetland Islands (Smith, 1993a). The Storegga Slide has been dated to 8,150BP (Haflidason et al., 2005), however more recent research on the deposits on the Shetlands suggests that some may not all be from Storegga, because 14C age dating gives younger ages of ~5,000 and 1,500 cal yr BP (Bondevik et al., 2005). A major challenge posed by the ages of these younger dates is that they are confined to the Shetlands; there is no indication of these younger tsunamis on mainland Scotland. If the dating is correct and the sediments are indeed from tsunamis, then the submarine landslides off Norway would be an unlikely source, so a local source seems most likely, but none has yet been identified. Alternatively a non-tsunami source for the sediments may explain their presence. The objectives of WB2 therefore are to investigate the tsunami deposits on Shetland that post-date the Storegga Slide, to validate their ages and, if possible, identify possible source locations of the submarine landslides that generated the tsunamis. On Shetland research on tsunami sediments was mainly based on evidence from coastal exposures around Sullom Voe where tsunami sands are dated as coeval with Storegga. The younger sands are mainly preserved in lake cores at locations on Shetland Mainland (Bondevik et al., 2005) where those of 5,000 BP overlie sands of Storegga age at 8,200 years BP age. At coastal sites along Basta Voe on Yell and at a mainland site at Dury Voe very young age dates of ~1,500 BP suggest an additional and very recent, late Holocene event (Bondevik et al., 2005; Dawson et al, 2006). A preliminary field excursion to the Shetlands carried out in 2013 discovered possible new tsunami deposits preserved in peat on central Yell at Whale Firth, Mid Yell Voe and Kirkabister. Subsequent 14C age dating of these deposits resulted in a variety of ages, many much younger than that of Storegga. The 14C method is known to be subject to major uncertainties because of contamination, for example initial age dating in the 1990’s at sites around Sullom Voe returned ages of around 5,000 years BP, although these were subsequently rejected in favour of the earlier, 8,200 BP Storegga event. Thus, validating the ages of the deposits on Yell, prospectively from a number of deposits laid down successively at one site (thereby reducing the sole reliance on 14C dating) was critical in validating the presence of more than one tsunami event on Shetland. The objective of the 2014 field visit to the Shetlands, therefore, was to return to Yell and validate the preliminary results from 2013; revisiting the sites at Whale Firth, Mid Yell and Kirkabister and searching the coastlines of Unst, Fetlar, Yell and north Mainland for additional sites where tsunami sediments might be preserved. Just before the visit new 14C dates from Mid Yell from samples collected in 2013 confirmed the previous results from other locations that had given a wide range of ages; at Whale Firth a single date gave a ‘young’ age of ~5,000 years BP, a range of ages with the oldest at 8,200 years BP were returned from Mid Yell Voe. We first visited sites on north Mainland around Sullom Voe, as it was here that the first indications of the Storegga tsunami were identified on Shetland in 1992. The deposits are classic as they contain rip-up clasts characteristic of tsunami deposits elsewhere. We then visited the sites at Basta Voe, Whale Firth, Mid Yell and Kirkabister. We carried out reconnaissance surveys on Unst, Fetlar, Yell and north Mainland. Preliminary results: 1. The new evidence supports the presence of tsunami sediments on Yell at Mid Yell Voe and Whale Firth, but the age of these sediments requires further research to confirm previous dating and their possible sources, 2. The youngest dated sediments (~1,500 BP) at Vasta Voe are most likely from a tsunami, but their limited areal extent suggests a local source, as yet undetermined, 3. The presence of three events at Mid Yell Voe based on surveys in 2013 was not confirmed, 4. The similarity of the deposits on Mid Yell with those around Sullom Voe on Mainland are suggestive of a similar source, 5. The wide range of the preliminary age dating at the Mid Yell sites (Whale Firth and Mid Yell Voe) is analogous to the early age dating of coastal deposits around Sullom Voe, suggesting the possibility of contamination of the peat material dated, 6. Whereas the 5,500BP event is identified in lake cores, no strongly supportive evidence for sands of this age were identified in the coastal sections, 7. Of the proposed three tsunami events proposed for Shetland only one, Storegga, has a confirmed source, 8. Further analysis of the peat stratigraphy at the coastal sites, reflects vegetation changes over the past ~8,000 years related to climate change, and these could be used to provide a broader context for the 14C age dating that may resolve the present dating issues, 9. Newly discovered sediments at Kirkabister require further research to determine their origin, 10. The origin(s) of the laminated deposits at Whale Firth, Mid Yell and Vatsetter is/are uncertain, but they are probably not from a tsunami, 11. No additional coastal exposures of peat with tsunami sands were located during the reconnaissance surveys on Mainland, Yell, Unst and Fetlar. Postscript; Immediately after this report was finalised, age dating of peat sections at Whale Firth and Mid Yell Voe confirmed that the sands preserved in the woody peat here are of Storegga age, ~8,200 cal yr BP

Tracking Streamer Blobs Into the Heliosphere

In this paper, we use coronal and heliospheric images from the STEREO spacecraft to track streamer blobs into the heliosphere and to observe them being swept up and compressed by the fast wind from low-latitude coronal holes. From an analysis of their elongation/time tracks, we discover a 'locus of enhanced visibility' where neighboring blobs pass each other along the line of sight and their corotating spiral is seen edge on. The detailed shape of this locus accounts for a variety of east-west asymmetries and allows us to recognize the spiral of blobs by its signatures in the STEREO images: In the eastern view from STEREO-A, the leading edge of the spiral is visible as a moving wavefront where foreground ejections overtake background ejections against the sky and then fade. In the western view from STEREO-B, the leading edge is only visible close to the Sun-spacecraft line where the radial path of ejections nearly coincides with the line of sight. In this case, we can track large-scale waves continuously back to the lower corona and see that they originate as face-on blobs.Comment: 15 pages plus 11 figures; figure 6 shows the 'locus of enhanced visibility', which we call 'the bean'. (accepted by ApJ 4/02/2010

A simulation of the IPS variations from a magnetohydrodynamical simulation

Calculations of the variations of interplanetary scintillation (IPS) from a disturbance simulated by a 3-D magnetohydrodynamical (MHD) model of the solar wind are presented. The simulated maps are compared with observations and it is found that the MHD model reproduces the qualitative features of observed disturbances. The disturbance produced by the MHD simulation is found to correspond in strength with the weakest disturbance which can be reliably detected by existing single station IPS observations