Indian summer monsoon precipitation climatology in a high-resolution regional climate model: Impacts of convective parameterization on systematic biases

In an attempt to develop a better simulation of the climatology of monsoon precipitation in climate models, this paper investigates the impacts of different convective closures on systematic biases of an Indian monsoon precipitation climatology in a high-resolution regional climate model. For this purpose, the Weather Research Forecast (WRF) model is run at 45- and 15-km (two-way nested) resolution with three convective parameterization schemes, namely the Grell-Devenyi (GD), the Betts-Miller-Janji (BMJ), and the Kain-Fritsch (KF), for the period 1 May-31 October 2001-07. The model is forced with the NCEP-NCAR reanalysis data as the initial and boundary conditions. The simulated June-September (JJAS) mean monsoon rainfall with the three convective schemes is compared with the observations. KF is found to have a high moist bias over the central and western coastal Indian region while GD shows the opposite. Among the three, BMJ is able to produce a reasonable mean monsoon pattern. In an attempt to get further insight into the seasonal bias and its evolution, the probability distribution function (PDF) of different rain-rate categories and their percentage contribution to the seasonal total are computed. BMJ and KF underestimate the observations for lighter rain rates and overestimate for rain-rate categories of more than 10 mm day -1. GD shows an overestimation for lighter rain and an underestimation of PDF for moderate categories. The seasonal patterns of evolution of PDF plots of three rain-rate categories are analyzed to determine whether the convective schemes show any systematic bias throughout the season or if they have problems during certain phases of the monsoon. This shows that the GD systematically overestimates the lighter rain rate and underestimates the moderate rain rate throughout the season, whereas BMJ and KF have problems in the initial stages. The heavy rain category is systematically overestimated by the KF compared to the other two. To further evaluate the proportionate contribution of each rain-rate bin to the total rain, the percentage contribution of each rain rate to the seasonal total is computed. Analyzing all the rain-rate simulations produced by the three schemes, it is found that KF has a moist bias and GD has a dry bias in the spatiotemporal distribution of the monsoon precipitation. Further, this paper investigates the causes behind the mean monsoon precipitation bias. It is shown that GD produces a model climate where the vertical velocity is less than that of the observations up to 500 hPa and the vertically integrated moist instability is also weaker. KF, on the other hand, shows a higher than the observed vertical velocity and a stronger moist instability. Along with this, the vertical profile of heating suggests a warmer middle level in the KF case and significantly reduced midlevel heating for GD. Thus, KF (GD) has produced a model atmosphere that has a stronger (weaker) convective instability to produce the observed bias in the model precipitation. BMJ is found to simulate a reasonable heating profile, along with the realistic moist instability and seasonal cycle of evaporation and condensation. Insight derived from the analysis is expected to help improve the convective parameterizations

Dengue and Zika virus cross-reactive human monoclonal antibodies protect against Spondweni virus infection and pathogenesis in mice

Summary: Spondweni virus (SPOV) is the flavivirus that is most closely related to Zika virus (ZIKV). Although SPOV causes sporadic human infections in Africa, recently it was found in Culex mosquitoes in Haiti. To investigate the pathogenic spectrum of SPOV, we developed infection models in mice. Although two SPOV strains failed to cause disease in immunocompetent mice, each accumulated in the brain, spleen, eye, testis, and kidney when type I interferon signaling was blocked and unexpectedly caused infection, immune cell infiltration, and swelling in the ankle. In pregnant mice, SPOV replicated in the placenta and fetus but did not cause placental insufficiency or microcephaly. We identified human antibodies from ZIKV or DENV immune subjects that neutralized SPOV infection and protected against lethal challenge. Our experiments describe similarities and differences in clinical syndromes between SPOV and ZIKV and suggest that their serological relatedness has implications for antibody therapeutics and flavivirus vaccine development. : Salazar et al. show that SPOV, the flavivirus most closely related to ZIKV, infects mice when type I interferon signaling is blocked. SPOV causes ankle swelling and infection in the foot, which is more typical of alphaviruses. Human antibodies from ZIKV or DENV subjects protect against lethal SPOV challenge. Keywords: flavivirus, pathogenesis, Spondweni virus, Zika virus, Dengue virus, arthritis, antibody therapy, immunit

Mental health status and its correlates among people living with HIV/AIDS in a tertiary care center of West Bengal

Background: People with mental disorders experience disproportionately higher rates of disability and mortality. Bidirectional link between mental illness and HIV/AIDS accelerates the disease progression, reduces willingness to access health care, promotes high risk behavior, leads to low medication adherence, and ultimately results in poor disease outcome. The present study was conducted with the objectives to estimate the prevalence of common mental disorders (CMD) among people living with HIV/AIDS (PLWHA) attending anti-retroviral therapy (ART) clinic at Burdwan medical college and hospital and to find out the association if any, between sociodemographic characteristics and CMD among the study population. Methods: A cross sectional descriptive study was conducted among 410 adult PLWHA, selected through systematic random sampling, registered at ART clinic of Burdwan medical college and hospital, West Bengal during October 2022 to February 2023. Interview of each study subject, with a pre-designed, pre-tested, semi-structured schedule was done to obtain socio-demographic characteristics and CMD was assessed using WHO’s self-reporting questionnaire (SRQ)-20. Univariate and multivariable logistic regression was performed to predict the factors associated with CMD. Data were analysed using SPSS v23.  Results: Prevalence of CMD was 30.2% among PLWHA attending ART clinic. In univariate logistic regression, female gender, persons not living with partner (un-married, widow/widower, divorced/separated), current smoker, pre-ART cases and persons with WHO stage 3 disease were found to be significantly associated with presence of CMD. But in multivariable logistic regression, persons not living with partner [AOR 2.114 (95% CI: 1.228-3.641)] and pre-ART cases [AOR 8.909 (95% CI: 4.770-16.640)] were remained statistically significant. Conclusions: Screening and treating the PLWHA suffering from CMD, should be considered to be an integral part of HIV care, support and treatment at the primary level

How aware are we regarding vector borne diseases? A community based study in a slum of Kolkata, India

Background: Vector borne diseases (VBDs) form a major part of the communicable diseases in India. Ignorance and impoverished conditions of people contribute in creating source and spread of vector borne diseases and hinder disease control strategy. Slums are more vulnerable to vector borne diseases because of poor environmental condition, standard of living, poverty and ignorance of the people. This study is a small endeavour to highlight the awareness of residents of slum area of Chetla, Kolkata, West Bengal, India regarding vector borne diseases. Objectives were to assess the awareness of the study population regarding different vector borne diseases and to find out the association of awareness with relevant demographic variables.Methods: A community based observational, cross-sectional study was conducted among adult population in a slum area of Chetla, Kolkata, West Bengal, India. Multivariate logistic analysis was done to find out association of awareness with relevant variables.Results: Awareness regarding malaria was good and that of dengue was satisfactory while awareness regarding other vector borne diseases was poor. Age, sex, caste, education and social class were found significantly associated with satisfactory awareness. Younger population i.e. age ≤35years, males, general caste people, literacy status above primary school and social class III and above had better awareness regarding vector borne diseases.Conclusions: This study uncovered the lacunae regarding awareness of the study population regarding vector borne diseases. It can be concluded that intensified efforts towards creating public awareness and mobilizing the community regarding the identified issues should be addressed

Chikungunya as a cause of acute febrile illness in southern Sri Lanka

10.1371/journal.pone.0082259PLoS ONE812-POLN

Study of Residual Stress Using Phased Array Ultrasonics in Ti-6AL-4V Wire-Arc Additively Manufactured Components

This paper presents a study on residual stress measurement in wire-arc additively manufactured (WAAM) titanium samples using the non-destructive method of phased array ultrasonics. The contour method (CM) was used for the verification of the phased array ultrasonic results. This allowed for a comparison of measurement methods to understand the effects on the distribution of residual stress (RS) within Ti-6Al-4V samples and the effectiveness of measurement of residual stress using phased array ultrasonics. From the results of the experiments, the phased array ultrasonic data were found to be in good agreement with the CM results and displayed similar residual stress distributions in the samples. The results of the individual elements of the phased array were also compared and an improvement in accuracy was found. From per-element results, anomalies were found and could be mitigated with the ability to average the results by using phased array ultrasonics. Therefore, based on these results, there is a strong case for the benefits of using phased array ultrasonics as a method of residual stress measurement for WAAM Ti-6Al-4V components over other existing residual stress measurement techniques

Concordance between conventional cytology and cell block of suspected malignant pleural effusion: A record-based study in a tertiary care center of eastern India

Background: Cytological study of pleural fluid helps establishing the underlying cause of pleural effusion. It is considered the most important tool in diagnosing malignancy in effusions. However, accurate identification of cellular morphology can be a problem in conventional cytology. Cell block preparation from pleural effusion aids in this diagnosis due to the preservation of tissue architecture, and multiple sections can be obtained for further studies. Aims and Objectives: The objectives of this study were to compare the diagnostic results of conventional cytology and cell block studies of suspected malignant pleural effusions and find out the diagnostic agreement or concordance between the two methods. Materials and Methods: A record-based study was conducted at the Department of Pathology on conventional cytology and cell block study reports of 150 suspected malignant pleural effusion cases over 35 months. The diagnoses were expressed in five categories – non-diagnostic, negative for malignancy, atypia of undetermined significance, suspicious for malignancy, and malignant. χ2 test was used to identify the percentage of malignancy reported. Agreement of both methods was assessed through Kappa statistics. Results: About 4.67% of cases were reported as malignant by conventional cytology, whereas cell block study diagnosed malignancy in 19.33% of cases. Relative diagnostic agreement between the two methods was 0.73 and concordance by Cohen’s Kappa was 0.34, which signifies fair concordance. Conclusion: Cell block study, though having a fair concordance, is much superior to conventional cytology smears in detecting malignant cells and diagnosing a pleural effusion as malignant

Patients in a private hospital in India leave the emergency department against medical advice for financial reasons

BACKGROUND: Some reports indicate financial concerns as a factor affecting ED patients leaving the acute care setting against medical advice (AMA). In India, no person is supposed to be denied urgent care because of inability to pay. Since a large proportion of the Indian health care system is financed by out-of-pocket expenses, we investigate the role of financial constraints for ED patients at a private hospital in India in leaving AMA. METHODS: A prospective ED-based cross-sectional survey of patients leaving AMA was conducted at a private hospital in India from 1 October 2010 to 31 December 2010. Descriptive statistics and the chi-square test were used to identify associations between financial factors and the decision to leave the hospital AMA. RESULTS: Overall, 55 (3.84%) ED patients left AMA, of which 46 (84%) reported leaving because of financial restrictions. Thirty-nine (71%) respondents indicated the medical bill would represent more that 25% of their annual income. Females (19/19) were more likely to leave AMA for financial reasons compared to males (27/36, p = 0.017). Among females who signed out AMA, the decision was never made by the female herself. CONCLUSION: The number of people leaving the ED AMA in a private Indian hospital is relatively high, with most leaving for financial reasons. In most cases, women did not decide to leave the ED AMA for themselves, whereas males did. This survey suggests that steps are needed to ensure that the inability to pay does not prevent emergent care from being provided

The impact of peening on residual stress in wire-arc additive manufactured Ti-6Al-4V using contour method and phased array ultrasonics

Additive Manufacturing (AM) is increasingly used to produce complex components, with Wire Arc Additive Manufacturing (WAAM) playing a crucial role in industries such as aerospace, particularly for titanium alloys like Ti-6Al-4V. However, WAAM introduces significant Residual Stress (RS) due to the high heat input, which can lead to component failure. Therefore, understanding how to evaluate RS in Ti-6Al-4V WAAM-manufactured components and minimizing its effects is essential. Peening can mitigate tensile RS by introducing compressive stress, making it important to assess its impact on WAAM samples. In this study, RS measurements were conducted using both the newly developed Phased Array Ultrasonics for Residual Stress Measurement (PAURS) and the well-established Contour Method. While various RS measurement techniques exist, there is a gap in understanding how PAURS can be effectively applied. To address this, The Contour Method was used to validate PAURS results on WAAM Ti-6Al-4V samples. RS was evaluated in both peened and unpeened samples, enabling a comparative analysis. Results showed that (I) PAURS and The Contour Method exhibited good qualitative agreement in as-built samples, and (II) peening effectively introduced up to 800 MPa compressive stress on the top surface of WAAM components