Compressive strength of heterogeneous masonry walls containing blends of brick types

The study presents a systematic approach for the evaluation of the compression strength of masonry walls composed of heterogeneous mixes of different types of blocks. First of all, the mechanics of a compressed heterogeneous masonry stack is investigated through a series of experimental tests and Finite Element models, then it is reviewed and discussed. Then, the problem of deriving the necessary material parameters entering the Hilsdorf formula is addressed. Solutions for the correct evaluation of the lacking data are presented based on the existing literature data. Finally, the well-known Hilsdorf formula is extended to the field of block blends with different mechanical properties. A deep experimental investigation on stacks and wallets made with fired clay, limestone and sandstone blocks is introduced for the first time. The comparison of the experimental data with the proposed theory points out the very good predictive capability of the extended Hilsdorf formula derived herein

Neuroprotection by Drugs, Nutraceuticals and Physical Activity

Acute and chronic neural injuries, including stroke, brain trauma and neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), Parkinson's disease (PD), and Alzheimer's disease (AD) are associated with high morbidity and mortality rates [...]

Evaluation of the residual carrying capacity of a large-scale model bridge through frequency shifts

Structural systems are often subjected to degradation processes due to different kinds of phenomena like unexpected loadings, ageing of the materials, and fatigue cycles. This is true, especially for bridges, in which their safety evaluation is crucial for planning maintenance activities. This paper discusses the experimental evaluation of the residual carrying capacity from frequency changes due to distributed damage scenarios. For this purpose, in the laboratory of the University of Bologna, an experimental reinforced concrete model bridge was built and loaded. The applied forces produced bending moments causing up to three increasing levels of damage severity, namely early and diffused concrete cracking, and finally rebar yielding. By processing the acceleration signals recorded during the dynamic tests on the model bridge, the main natural frequencies of the bridge were obtained and the remaining bearing capacity was estimated based on the damage state. The opening and closure of cracks during a dynamic excitation produced a biased estimation of natural frequencies related to each damaged condition. The frequency decay predicted by the theory of breathing cracks applied to the performed experiments properly estimated the losses in the carrying capacity

P-glycoprotein (ABCB1) and oxidative stress: Focus on Alzheimer's disease

ATP-binding cassette (ABC) transporters, in particular P-glycoprotein (encoded by ABCB1), are important and selective elements of the blood-brain barrier (BBB), and they actively contribute to brain homeostasis. Changes in ABCB1 expression and/or function at the BBB may not only alter the expression and function of other molecules at the BBB but also affect brain environment. Over the last decade, a number of reports have shown that ABCB1 actively mediates the transport of beta amyloid (A\u3b2) peptide. This finding has opened up an entirely new line of research in the field of Alzheimer's disease (AD). Indeed, despite intense research efforts, AD remains an unsolved pathology and effective therapies are still unavailable. Here, we review the crucial role of ABCB1 in the A\u3b2 transport and how oxidative stress may interfere with this process. A detailed understanding of ABCB1 regulation can provide the basis for improved neuroprotection in AD and also enhanced therapeutic drug delivery to the brain

Protective effects of 6-(Methylsulfinyl)hexyl isothiocyanate on Aβ1-42-induced cognitive deficit, oxidative stress, inflammation, and apoptosis in mice

Alzheimer’s disease (AD) is the most common form of dementia among older people. Although soluble amyloid species are recognized triggers of the disease, no therapeutic approach is able to stop it. 6-(Methylsulfinyl)hexyl isothiocyanate (6-MSITC) is a major bioactive compound in Wasabia japonica, which is a typical Japanese pungent spice. Recently, in vivo and in vitro studies demonstrated that 6-MSITC has several biological properties. The aim of the present study was to investigate the neuroprotective activity of 6-MSITC in a murine AD model, induced by intracerebroventricular injection of β-amyloid oligomers (Aβ1-42O). The treatment with 6-MSITC started 1 h after the surgery for the next 10 days. Behavioral analysis showed that 6-MSITC ameliorated Aβ1-42O-induced memory impairments. The decrease of glutathione levels and increase of reactive oxygen species in hippocampal tissues following Aβ1-42O injection were reduced by 6-MSITC. Moreover, activation of caspases, increase of inflammatory factors, and phosphorylation of ERK and GSK3 were inhibited by 6-MSITC. These results highlighted an interesting neuroprotective activity of 6-MSITC, which was able to restore a physiological oxidative status, interfere positively with Nrf2-pathway, decrease apoptosis and neuroinflammation and contribute to behavioral recovery. Taken together, these findings demonstrated that 6-MSITC could be a promising complement for AD therapy

Esculetin provides neuroprotection against mutant huntingtin-induced toxicity in huntington’s disease models

Huntington’s disease (HD) is a neurodegenerative disorder caused by an abnormal CAG trinucleotide repeat expansion within exon 1 of the huntingtin (HTT) gene. This mutation leads to the production of mutant HTT (mHTT) protein which triggers neuronal death through several mechanisms. Here, we investigated the neuroprotective effects of esculetin (ESC), a bioactive phenolic compound, in an inducible PC12 model and a transgenic Drosophila melanogaster model of HD, both of which express mHTT fragments. ESC partially inhibited the progression of mHTT aggregation and reduced neuronal death through its ability to counteract the oxidative stress and mitochondria impairment elicited by mHTT in the PC12 model. The ability of ESC to counteract neuronal death was also confirmed in the transgenic Drosophila model. Although ESC did not modify the lifespan of the transgenic Drosophila, it still seemed to have a positive impact on the HD phenotype of this model. Based on our findings, ESC may be further studied as a potential neuroprotective agent in a rodent transgenic model of HD

Poverty and Wellbeing Impacts of Microfinance : What Do We Know?

Over the last 35 years, microfinance has been generally regarded as an effective policy tool in the fight against poverty. Yet, the question of whether access to credit leads to poverty reduction and improved wellbeing remains open. To address this question, we conduct a systematic review of the quantitative literature of microfinance’s impacts in the developing world, and develop a theory of change that links inputs to impacts on several welfare outcomes. Overall, we find that the limited comparability of outcomes and the heterogeneity of microfinance-lending technologies, together with a considerable variation in socio-economic conditions and contexts in which impact studies have been conducted, render the interpretation and generalization of findings intricate. Our results indicate that, at best, microfinance induces short-term dynamism in the financial life of the poor; however, we do not find compelling evidence that this dynamism leads to increases in income, consumption, human capital and assets, and, ultimately, a reduction in poverty

Oxidative Stress: How Has It Been Considered in the Design of New Drug Candidates for Neurodegenerative Diseases?

Editorial on the Research Topi