Antiparkinsonian efficacy of guanosine in rodent models of movement disorder

Guanosine (GUO) is a guanine-based purine nucleoside with important trophic functions and promising neuroprotective properties. Although the neuroprotective effects of GUO have been corroborated in cellular models of Parkinson's disease (PD), its efficacy as an antiparkinsonian agent has not been fully explored in PD animal models. Accordingly, we evaluated the effectiveness of GUO in reversing motor impairments in several rodent movement disorder models, including catalepsy, tremor, and hemiparkinsonism. Our results showed that orally administered GUO antagonized reserpine-mediated catalepsy, reduced reserpine-induced tremulous jaw movements, and potentiated the number of contralateral rotations induced by L-3,4-dihydroxyphenylalanine in unilaterally 6-hydroxidopamine-lesioned rats. In addition, at 5 and 7.5 mg/kg, GUO inhibited L-DOPA-induced dyskinesia in rats chronically treated with a pro-dopaminergic agent. Overall, we describe the therapeutic potential of GUO, which may be effective not only for reversing parkinsonian motor impairments but also for reducing dyskinesia induced by treatment for PD

The VIMOS Public Extragalactic Redshift Survey (VIPERS). Never mind the gaps: comparing techniques to restore homogeneous sky coverage

[Abridged] Non-uniform sampling and gaps in sky coverage are common in galaxy redshift surveys, but these effects can degrade galaxy counts-in-cells and density estimates. We carry out a comparison of methods that aim to fill the gaps to correct for the systematic effects. Our study is motivated by the analysis of the VIMOS Extragalactic Redshift Survey (VIPERS), a flux-limited survey (i<22.5) based on one-pass observations with VIMOS, with gaps covering 25% of the surveyed area and a mean sampling rate of 35%. Our findings are applicable to other surveys with similar observing strategies. We compare 1) two algorithms based on photometric redshift, that assign redshifts to galaxies based on the spectroscopic redshifts of the nearest neighbours, 2) two Bayesian methods, the Wiener filter and the Poisson-Lognormal filter. Using galaxy mock catalogues we quantify the accuracy of the counts-in-cells measurements on scales of R=5 and 8 Mpc/h after applying each of these methods. We also study how they perform to account for spectroscopic redshift error and inhomogeneous and sparse sampling rate. We find that in VIPERS the errors in counts-in-cells measurements on R<10 Mpc/h scales are dominated by the sparseness of the sample. All methods underpredict by 20-35% the counts at high densities. This systematic bias is of the same order as random errors. No method outperforms the others. Random and systematic errors decrease for larger cells. We show that it is possible to separate the lowest and highest densities on scales of 5 Mpc/h at redshifts 0.5<z<1.1, over a large volume such as in VIPERS survey. This is vital for the characterisation of cosmic variance and rare populations (e.g, brightest galaxies) in environmental studies at these redshifts.Comment: 17 pages, 13 figures, accepted for publication in A&A (revised version after minor revision and language editing

The XMM-Newton wide-field survey in the COSMOS field. IV: X-ray spectral properties of Active Galactic Nuclei

We present a detailed spectral analysis of point-like X-ray sources in the XMM-COSMOS field. Our sample of 135 sources only includes those that have more than 100 net counts in the 0.3-10 keV energy band and have been identified through optical spectroscopy. The majority of the sources are well described by a simple power-law model with either no absorption (76%) or a significant intrinsic, absorbing column (20%).As expected, the distribution of intrinsic absorbing column densities is markedly different between AGN with or without broad optical emission lines. We find within our sample four Type-2 QSOs candidates (L_X > 10^44 erg/s, N_H > 10^22 cm^-2), with a spectral energy distribution well reproduced by a composite Seyfert-2 spectrum, that demonstrates the strength of the wide field XMM/COSMOS survey to detect these rare and underrepresented sources.Comment: 16 pages, ApJS COSMOS Special Issue, 2007 in press. The full-resolution version is available at http://www.mpe.mpg.de/XMMCosmos/PAPERS/mainieri_cosmos.ps.g

The bimodality of the 10k zCOSMOS-bright galaxies up to z ~ 1: a new statistical and portable classification based on the optical galaxy properties

Our goal is to develop a new and reliable statistical method to classify galaxies from large surveys. We probe the reliability of the method by comparing it with a three-dimensional classification cube, using the same set of spectral, photometric and morphological parameters.We applied two different methods of classification to a sample of galaxies extracted from the zCOSMOS redshift survey, in the redshift range 0.5 < z < 1.3. The first method is the combination of three independent classification schemes, while the second method exploits an entirely new approach based on statistical analyses like Principal Component Analysis (PCA) and Unsupervised Fuzzy Partition (UFP) clustering method. The PCA+UFP method has been applied also to a lower redshift sample (z < 0.5), exploiting the same set of data but the spectral ones, replaced by the equivalent width of H$\alpha$. The comparison between the two methods shows fairly good agreement on the definition on the two main clusters, the early-type and the late-type galaxies ones. Our PCA-UFP method of classification is robust, flexible and capable of identifying the two main populations of galaxies as well as the intermediate population. The intermediate galaxy population shows many of the properties of the green valley galaxies, and constitutes a more coherent and homogeneous population. The fairly large redshift range of the studied sample allows us to behold the downsizing effect: galaxies with masses of the order of $3\cdot 10^{10}$ Msun mainly are found in transition from the late type to the early type group at $z>0.5$, while galaxies with lower masses - of the order of $10^{10}$ Msun - are in transition at later epochs; galaxies with $M <10^{10}$ Msun did not begin their transition yet, while galaxies with very large masses ($M > 5\cdot 10^{10}$ Msun) mostly completed their transition before $z\sim 1$.Comment: 16 pages, 14 figures, accepted for publication in A&

The VIMOS VLT Deep Survey final data release: a spectroscopic sample of 35016 galaxies and AGN out to z~6.7 selected with 17.5<=i_{AB}<=24.7

We describe the completed VIMOS VLT Deep Survey, and the final data release of 35016 galaxies and type-I AGN with measured spectroscopic redshifts up to redshift z~6.7, in areas 0.142 to 8.7 square degrees, and volumes from 0.5x10^6 to 2x10^7h^-3Mpc^3. We have selected samples of galaxies based solely on their i-band magnitude reaching i_{AB}=24.75. Spectra have been obtained with VIMOS on the ESO-VLT, integrating 0.75h, 4.5h and 18h for the Wide, Deep, and Ultra-Deep nested surveys. A total of 1263 galaxies have been re-observed independently within the VVDS, and from the VIPERS and MASSIV surveys. They are used to establish the redshift measurements reliability, to assess completeness, and to provide a weighting scheme taking into account the survey selection function. We describe the main properties of the VVDS samples, and the VVDS is compared to other spectroscopic surveys. In total we have obtained spectroscopic redshifts for 34594 galaxies, 422 type-I AGN, and 12430 Galactic stars. The survey has enabled to identify galaxies up to very high redshifts with 4669 redshifts in 1<=z_{spec}<=2, 561 in 2<=z_{spec}<=3 and 468 with z_{spec}>3, and specific populations like LAE have been identified out to z=6.62. We show that the VVDS occupies a unique place in the parameter space defined by area, depth, redshift coverage, and number of spectra. The VVDS provides a comprehensive survey of the distant universe, covering all epochs since z, or more than 12 Gyr of cosmic time, with a uniform selection, the largest such sample to date. A wealth of science results derived from the VVDS have shed new light on the evolution of galaxies and AGN, and their distribution in space, over this large cosmic time. A final public release of the complete VVDS spectroscopic redshift sample is available at http://cesam.lam.fr/vvds.Comment: Submitted 30 June 2013, Accepted 22 August 2013. Updated with published versio

The VIMOS Public Extragalactic Redshift Survey (VIPERS): A quiescent formation of massive red-sequence galaxies over the past 9 Gyr

We explore the evolution of the Colour-Magnitude Relation (CMR) and Luminosity Function (LF) at 0.4<z<1.3 from the VIMOS Public Extragalactic Redshift Survey (VIPERS) using ~45,000 galaxies with precise spectroscopic redshifts down to i'_AB<22.5 over ~10.32 deg^2 in two fields. From z=0.5 to z=1.3 the LF and CMR are well defined for different galaxy populations and M^*_B evolves by ~1.04(1.09)+/-0.06(0.10) mag for the total (red) galaxy sample. We compare different criteria for selecting early-type galaxies (ETGs): (1) fixed cut in rest-frame (U-V) colours, (2) evolving cut in (U-V) colours, (3) rest-frame (NUV-r')-(r'-K) colour selection, and (4) SED classification. Regardless of the method we measure a consistent evolution of the red-sequence (RS). Between 0.4<z<1.3 we find a moderate evolution of the RS intercept of Delta(U-V)=0.28+/-0.14 mag, favouring exponentially declining star formation (SF) histories with SF truncation at 1.7<=z<=2.3. Together with the rise in the ETG number density by 0.64 dex since z=1, this suggests a rapid build-up of massive galaxies (M>10^11 M_sun) and expeditious RS formation over a short period of ~1.5 Gyr starting before z=1. This is supported by the detection of ongoing SF in ETGs at 0.9<z<1.0, in contrast with the quiescent red stellar populations of ETGs at 0.5<z<0.6. There is an increase in the observed CMR scatter with redshift, two times larger than in galaxy clusters and at variance with theoretical models. We discuss possible physical mechanisms that support the observed evolution of the red galaxy population. Our findings point out that massive galaxies have experienced a sharp SF quenching at z~1 with only limited additional merging. In contrast, less-massive galaxies experience a mix of SF truncation and minor mergers which build-up the low- and intermediate-mass end of the CMR.Comment: 27 pages, 21 figures, accepted for publication in A&

VIPERS: An Unprecedented View of Galaxies and Large-Scale Structure Halfway Back in the Life of the Universe

The VIMOS Public Extragalactic Redshift Survey (VIPERS) is an ongoing ESO Large Programme to map in detail the large-scale distribution of galaxies at 0.5 < z <1.2. With a combination of volume and sampling density that is unique for these redshifts, it focuses on measuring galaxy clustering and related cosmological quantities as part of the grand challenge of understanding the origin of cosmic acceleration. VIPERS has also been designed to guarantee a broader legacy, allowing detailed investigations of the properties and evolutionary trends of z~1 galaxies. The survey strategy exploits the specific advantages of the VIMOS spectrograph at the VLT, aiming at a final sample of nearly 100,000 galaxy redshifts to iAB = 22.5 mag, which represents the largest redshift survey ever performed with ESO telescopes. In this introductory article we describe the survey construction, together with early results based on a first sample of ~55,000 galaxies.Comment: 6 pages, 8 figures; introductory pape

The VIMOS Public Extragalactic Redshift Survey (VIPERS). Exploring the dependence of the three-point correlation function on stellar mass and luminosity at 0.5<z<1.1

The three-point correlation function (3PCF) is a powerful probe to investigate the clustering of matter in the Universe in a complementary way with respect to lower-order statistics, providing additional information with respect to the two-point correlation function and allowing us to shed light on biasing, nonlinear processes, and deviations from Gaussian statistics. In this paper, we analyse the first data release of the VIMOS Public Extragalactic Redshift Survey (VIPERS), determining the dependence of the three-point correlation function on luminosity and stellar mass at $z=[0.5,1.1]$. We exploit the VIPERS Public Data Release 1, consisting of more than 50,000 galaxies with B-band magnitudes in the range $-21.6\lesssim M_{\rm B}-5\log(h)\lesssim-19.9$ and stellar masses in the range $9.8\lesssim\log(M_\star[h^{-2}\,M_\odot])\lesssim 10.7$. We measure both the connected 3PCF and the reduced 3PCF in redshift space, probing different configurations and scales, in the range $2.5<r\,$[Mpc/h]$<20$. We find a significant dependence of the reduced 3PCF on scales and triangle shapes, with stronger anisotropy at larger scales ($r\sim10$ Mpc/h) and an almost flat trend at smaller scales, $r\sim2.5$ Mpc/h. Massive and luminous galaxies present a larger connected 3PCF, while the reduced 3PCF is remarkably insensitive to magnitude and stellar masses in the range we explored. These trends, already observed at low redshifts, are confirmed for the first time to be still valid up to $z=1.1$, providing support to the hierarchical scenario for which massive and bright systems are expected to be more clustered. The possibility of using the measured 3PCF to provide independent constraints on the linear galaxy bias $b$ has also been explored, showing promising results in agreement with other probes.Comment: 12 pages, 11 figures, 2 tables, accepted for publication in A&

The XMM-Newton Wide-Field Survey in the COSMOS Field: Statistical Properties of Clusters of Galaxies

We present the results of a search for galaxy clusters in the first 36 XMM-Newton pointings on the Cosmic Evolution Survey (COSMOS) field. We reach a depth for a total cluster flux in the 0.5-2 keV band of 3 × 10^(-15) ergs cm^(-2) s^(-1), having one of the widest XMM-Newton contiguous raster surveys, covering an area of 2.1 deg^2. Cluster candidates are identified through a wavelet detection of extended X-ray emission. Verification of the cluster candidates is done based on a galaxy concentration analysis in redshift slices of thickness 0.1-0.2 in redshift, using the multiband photometric catalog of the COSMOS field and restricting the search to z S)-log S distribution compares well with previous results, although yielding a somewhat higher number of clusters at similar fluxes. The X-ray luminosity function of COSMOS clusters matches well the results of nearby surveys, providing a comparably tight constraint on the faint-end slope of α = 1.93 ± 0.04. For the probed luminosity range of (8 × 10^(42))-(2 × 10^(44)) ergs s^(-1), our survey is in agreement with and adds significantly to the existing data on the cluster luminosity function at high redshifts and implies no substantial evolution at these luminosities to z = 1.3