Alien Registration- Tatarczuk, Juzefa V. (Portland, Cumberland County)

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Application de la méthode des transformateurs saturés à la mesure et régulation du champ magnétique d'un spectromètre β à double focalisation π √2 avec noyau de fer

On décrit un nouveau magnétomètre pour mesurer les champs magnétiques constants ou lentement variables dans l'intervalle de variation entre 10 -4 et 3 x 102 Oe. La précision relative est supérieure à 2,5 X 10-5 entre 7 et 300 Oe. Le champ magnétique d'un spectromètre β à double focalisation π √2 du type Siegbahn-Svartholm est stabilisé par un servomécanisme. On utilise comme signal d'erreur la différence entre une tension proportionnelle au champ d'induction magnétique et une tension de référence

Modeling of CO2 solubility in aqueous amine solutions using hybrid neural network

The use of chemical absorption with amine aqueous solutions has become of great interest as potential post-combustion CO2 removal process. In such processes, knowledge of solution equilibrium conditions is essential and is necessary to design CO2 treating equipment. Model of solubility of CO2 in N-methylidiethanolamine (MDEA) aqueous solution is presented. Model, based on well-known Kent-Eisenberg structure, was combined with neural network. Such combination forms hybrid neural network model. Neural network was used to determine amine protonation equilibrium constant and further was employed in hybrid neural network to predict equilibrium partial pressure of CO2 over MDEA aqueous solution in different temperatures and for various solution concentrations. Results show very good agreement between model and experimental data.Marcin Ste

Investigation of Effects of the Amine Solutions Composition on Carbon Dioxide Absorption Rate and Capacity

Increasing importance of CO2 emission reduction cause necessity to find the most effective separation method of this gas from flue gases. The most promising seems to be a chemical absorption in aqueous solutions of alkanolamines. In order to reduce high energy consumption of this process, it is necessary to develop new solutions which will be characterized by the best absorption rate and capacity e.g. through the appropriate composition of amine blends. Experiments were carried out on the solutions containing primary amines, tertiary amines, sterically amines, cyclic amines and organic liquids. The experiments included CO2 absorption equilibriums and rate determination for temperature range 20-60 deg. C. The results showed a beneficial effect of using blends containing primary amines and sterically hindered amines with organic liquids on both the absorption rate and the absorption capacity.Andrzej Wil

Is thyroid autoimmunity associated with subclinical atherosclerosis in young women with type 1 diabetes mellitus?

Wstęp: Przypuszcza się, że autoimmunizacja może przyczyniać się do powikłań sercowo-naczyniowych i być ważnym czynnikiem wyzwalającym procesy prowadzące do miażdżycy, zwłaszcza w cukrzycy typu 1 (CT1). Niniejsze badanie miało na celu odpowiedź na pytanie, czy markery autoimmunizacji tarczycy są związane ze zwiększoną grubością kompleksu intima-media tętnicy szyjnej wspólnej (cIMT) u młodych, bezobjawowych kobiet z CT1. Materiał i metody: Badana populacja składała się z 102 kobiet, w tym z 72 z CT1 i 30 zdrowych kobiet z grupy kontrolnej. Wszyscy pacjenci mieli prawidłowy poziom hormonów tarczycy. Grupę CT1 podzielono na dwie podgrupy w zależności od miana przeciwciał przeciwko peroksydazie (aTPO) w surowicy na: 41 kobiet aTPO dodatnich (CT1 aTPO+) i 31 kobiet aTPO ujemnych (CT1 aTPO-). U wszystkich pacjentów oceniano miano aTPO, miano przeciwciał przeciw tyreoglobulinie (aTG), stężenie hormonu tyreotropowego (TSH), wolnej tyroksyny (FT3), wolnej trójjodotyroniny (FT4), parametry lipidowe, hemoglobinę glikowaną, wykonano badanie ultrasonograficzne tarczycy oraz ocenę cIMT. Oceniono związek cIMT z różnymi parametrami związanymi z autoimmunizacją tarczycy. Wyniki: CIMT była istotnie większa u kobiet z T1DM aTPO+ (0,66±0,10 mm) w porównaniu do kobiet z T1DM aTPO- (0,59±0,11 mm) i grupy kontrolnej (0,58±0,10 mm) (p=0,007, p=0,001). U wszystkich kobiet cIMT była istotnie, dodatnio skorelowana z aTPO (p=0,005, r=0,273), czasem trwania zapalenia tarczycy Hashimoto (HT) (p=0,00015, r=0,367), tygodniową dawką lewotyroksyny (p=0,006, r=0,269), ultrasonograficznymi cechami HT (p=0,004, r=0,281) oraz odwrotnie ze stężeniem fT3 (p=0,014, r=-0. 243) i stosunkiem FT3/FT4 (p=0,042, r=-0,201). Analiza regresji logistycznej wykazała, że czas trwania HT (OR: 1,102, 95%CI: 1,008-1,206, p=0,032) oraz dodatni wywiad rodzinny w kierunku HT (OR: 3,909, 95%CI: 1,014 -15,071, p=0,045) były czynnikami ryzyka zwiększonej cIMT. Analiza regresji wieloczynnikowej wykazała jednak, że badane parametry związane z autoimmunizacją tarczycy nie są niezależnymi czynnikami ryzyka zwiększenia cIMT. Wnioski: Podsumowując, poszerzyliśmy dane dotyczące cIMT u młodych kobiet z CT1 i wykazaliśmy, że autoimmunizacja tarczycy, a w szczególności czas ekspozycji na przeciwciała przeciwtarczycowe, pomimo odpowiedniej substytucji lewotyroksyną, wiąże się z subkliniczną miażdżycą u młodych kobiet z T1DM. Parametry związane z autoimmunizacją tarczycy nie są jednak niezależnymi czynnikami ryzyka zwiększenia cIMT u kobiet w eutyreozie.Introduction: It has been hypothesized that autoimmunity may contribute to cardiovascular complications and may be an important trigger for processes leading to atherosclerosis, especially in type 1 diabetes mellitus (T1DM). This pilot study aimed to answer the question of whether markers of thyroid autoimmunity are associated with increased carotid intima-media thickness (cIMT) in young, asymptomatic T1DM women. Material and methods: The study population consisted of 102 women, including 72 with T1DM and 30 healthy controls. All patients had thyroid hormones within the normal range. According to the antiperoxidase antibodies (aTPO) titre, the T1DM women were divided into an aTPO-positive (T1DM aTPO+) (n = 41) and an aTPO-negative (T1DM aTPO–) (n = 31) group. In all patients, aTPO, thyroglobulin antibody (aTG) titres, thyroid-stimulating hormone (TSH), free thyroxine (FT3), free triiodothyronine (FT4), lipid parameters, glycated haemoglobin, thyroid ultrasonography, and cIMT assessment were evaluated. The association of cIMT with different risk factors related to thyroid autoimmunity was determined. Results: Carotid intima-media thickness was significantly greater in T1DM aTPO+ females (0.66 ± 0.10 mm) than in T1DM aTPO– (0.59 ± 0.11 mm) and healthy controls (0.58 ± 0.10 mm) (p = 0.007, p = 0.001, respectively). In all women cIMT was significantly, positively correlated with aTPO (p = 0.005, r = 0.273), Hashimoto’s thyroiditis (HT) duration (p = 0.00015, r = 0.367), levothyroxine dose per week (p = 0.006, r = 0.269), and ultrasound features of HT (p = 0.004, r = 0.281) and inversely with fT3 concentration (p = 0.014, r = –0.243) and FT3/FT4 ratio (p = 0.042, r = –0.201). A logistic regression analysis showed that HT duration (OR: 1.102, 95% CI: 1.008–1.206, p = 0.032) and a positive history family of HT (OR: 3.909, 95%CI: 1.014–15.071, p = 0.045) were risk factors for increased cIMT. However, multivariate regression analysis showed that the studied parameters related to thyroid autoimmunity are not independent risk factors for increased cIMT. Conclusions: We expanded the data on cIMT in young women with T1DM and showed that thyroid autoimmunity, and in particular the duration of exposure to anti-thyroid antibodies, despite adequate levothyroxine substitution, is associated with subclinical atherosclerosis in young women with T1DM. However, thyroid-related parameters are not independent risk factors for increased cIMT in euthyroid women.

Is thyroid autoimmunity associated with subclinical atherosclerosis in young women with type 1 diabetes mellitus?

Introduction: It has been hypothesized that autoimmunity may contribute to cardiovascular complications and may be an important trig- ger for processes leading to atherosclerosis, especially in type 1 diabetes mellitus (T1DM). This pilot study aimed to answer the question of whether markers of thyroid autoimmunity are associated with increased carotid intima-media thickness (cIMT) in young, asymptomatic T1DM women. Material and methods: The study population consisted of 102 women, including 72 with T1DM and 30 healthy controls. All patients had thyroid hormones within the normal range. According to the antiperoxidase antibodies (aTPO) titre, the T1DM women were divided into an aTPO-positive (T1DM aTPO+) (n = 41) and an aTPO-negative (T1DM aTPO–) (n = 31) group. In all patients, aTPO, thyroglobulin antibody (aTG) titres, thyroid-stimulating hormone (TSH), free thyroxine (FT3), free triiodothyronine (FT4), lipid parameters, glycated haemoglobin, thyroid ultrasonography, and cIMT assessment were evaluated. The association of cIMT with different risk factors related to thyroid autoimmunity was determined. Results: Carotid intima-media thickness was significantly greater in T1DM aTPO+ females (0.66 ± 0.10 mm) than in T1DM aTPO– (0.59 ± 0.11 mm) and healthy controls (0.58 ± 0.10 mm) (p = 0.007, p = 0.001, respectively). In all women cIMT was significantly, positively correlated with aTPO (p = 0.005, r = 0.273), Hashimoto’s thyroiditis (HT) duration (p = 0.00015, r = 0.367), levothyroxine dose per week (p = 0.006, r = 0.269), and ultrasound features of HT (p = 0.004, r = 0.281) and inversely with fT3 concentration (p = 0.014, r = –0.243) and FT3/FT4 ratio (p = 0.042, r = –0.201). A logistic regression analysis showed that HT duration (OR: 1.102, 95% CI: 1.008–1.206, p = 0.032) and a positive history family of HT (OR: 3.909, 95%CI: 1.014–15.071, p = 0.045) were risk factors for increased cIMT. However, multivariate regression analysis showed that the studied parameters related to thyroid autoimmunity are not independent risk factors for increased cIMT. Conclusions: We expanded the data on cIMT in young women with T1DM and showed that thyroid autoimmunity, and in particular the duration of exposure to anti-thyroid antibodies, despite adequate levothyroxine substitution, is associated with subclinical atherosclerosis in young women with T1DM. However, thyroid-related parameters are not independent risk factors for increased cIMT in euthyroid women.This research was funded by a Diabetes Poland Scientific Grant (27.08.2020)

Association of antithyroid peroxidase antibodies with cardiac function in euthyroid women with type 1 diabetes mellitus — assessment with two-dimensional speckle-tracking echocardiography

Introduction: The presence of diabetes is associated with loss of cardioprotection in premenopausal women; however, the mechanisms involved remain unknown. Autoimmune factors are suspected to play a role in cardiovascular complications, especially in type 1 diabetes (T1DM). The aim of this pilot study was to explore whether antithyroid peroxidase antibody (aTPO) as a marker of increased immune activity is related to cardiac dysfunction in young, asymptomatic women with T1DM. Material and methods: Eighty-eight euthyroid women (59 with T1DM and 29 healthy controls) underwent physical examination, laboratory tests, thyroid ultrasound, and two-dimensional speckle-tracking echocardiography. According to the antiperoxidase antibodies (aTPO) titre, the T1DM women were divided into an aTPO positive (T1DM aTPO+) (n = 34) and an aTPO negative (T1DM aTPO–) (n = 25) group. The relationship between thyroid autoimmunity parameters and echocardiographic parameters was evaluated. Results: Global longitudinal strain (GLS) was slightly reduced in the T1DM aTPO+ group compared to T1DM aTPO– and significantly compared to controls (p = 0.051 and p = 0.015, respectively). Although, the lower values of longitudinal strain of left ventricular were found in the majority of segments in the T1DM aTPO+ group in comparison to T1DM aTPO– and controls, significant differences were only found in the two-chamber view (specifically in the anterior segments) between the T1DM aTPO+ and T1DM aTPO– groups (p = 0.030) and in the four-chamber view (specifically in the anterolateral segments) between the T1DM aTPO+ group and controls (p = 0.021). Echocardiographic parameters of diastolic and systolic function of both ventricles were significantly correlated with parameters of thyroid autoimmunity. A logistic regression analysis showed that Hashimoto’s thyroiditis (HT) duration [odds ratio (OR): 0.997, 95% confidence interval (CI): 0.995-0.999, p = 0.008), the dose of levothyroxine (OR: 0.814, 95% CI: 0.689–0.960, p = 0.013), and reduced echogenicity on thyroid ultrasound (OR: 0.309, 95% CI: 0.120–0.793, p = 0.013) had a significant influence on reduced GLS. Conclusions: Our results suggest that coexistence of aTPO with T1DM was associated with poorer myocardial function, particularly in the anterior and anterolateral segments, which may be related to an autoimmune factor. The impaired function of these segments is probably the first sign of myocardial systolic dysfunction in women with T1DM, which needs to be confirmed in further studies.This research was funded by a Diabetes Poland Scientific Grant (27.08.2020)