Bulk charges in eleven dimensions

Eleven dimensional supergravity has electric type currents arising from the Chern-Simon and anomaly terms in the action. However the bulk charge integrates to zero for asymptotically flat solutions with topological trivial spatial sections. We show that by relaxing the boundary conditions to generalisations of the ALE and ALF boundary conditions in four dimensions one can obtain static solutions with a bulk charge preserving between 1/16 and 1/4 of the supersymmetries. One can introduce membranes with the same sign of charge into these backgrounds. This raises the possibility that these generalized membranes might decay quantum mechanically to leave just a bulk distribution of charge. Alternatively and more probably, a bulk distribution of charge can decay into a collection of singlely charged membranes. Dimensional reductions of these solutions lead to novel representations of extreme black holes in four dimensions with up to four charges. We discuss how the eleven-dimensional Kaluza-Klein monopole wrapped around a space with non-zero first Pontryagin class picks up an electric charge proportional to the Pontryagin number.Comment: 26 pages, ReVTeX, typos correcte

Kaluza-Klein Holography

We construct a holographic map between asymptotically AdS_5 x S^5 solutions of 10d supergravity and vacuum expectation values of gauge invariant operators of the dual QFT. The ingredients that enter in the construction are (i) gauge invariant variables so that the KK reduction is independent of any choice of gauge fixing; (ii) the non-linear KK reduction map from 10 to 5 dimensions (constructed perturbatively in the number of fields); (iii) application of holographic renormalization. A non-trivial role in the last step is played by extremal couplings. This map allows one to reliably compute vevs of operators dual to any KK fields. As an application we consider a Coulomb branch solution and compute the first two non-trivial vevs, involving operators of dimension 2 and 4, and reproduce the field theory result, in agreement with non-renormalization theorems. This constitutes the first quantitative test of the gravity/gauge theory duality away from the conformal point involving a vev of an operator dual to a KK field (which is not one of the gauged supergravity fields).Comment: 47 pages, v2: minor improvements, version to appear in JHE

Ebola virus disease epidemic in West Africa: Lessons learned and issues arising from West African countries

© Royal College of Physicians 2015. All rights reserved.The current Ebola virus disease (EVD) outbreak ravaging three nations in West Africa has affected more than 14,000 persons and killed over 5,000. It is the longest and most widely spread Ebola epidemic ever seen. At the time of this overview (written November 2014), having affected eight different nations, Nigeria and Senegal were able to control and eliminate the virus within a record time. Ghana has successfully, to date, kept the virus away from the country, despite economic and social relationships with affected nations. What lessons can we learn from Nigeria, Senegal and Ghana in the current epidemic? How can the world improve the health systems in low- and middle-income countries to effectively manage future outbreaks? Recently, the Royal College of Physicians launched a new partnership with the West African College of Physicians to curtail the effects of HIV/AIDS, malaria and tuberculosis in the region. We believe that strengthened health systems, skilled human resources for health and national ownership of problems are key to effective management of outbreaks such as EVD

Key performance indicators for successful simulation projects

There are many factors that may contribute to the successful delivery of a simulation project. To provide a structured approach to assessing the impact various factors have on project success, we propose a top-down framework whereby 15 Key Performance Indicators (KPI) are developed that represent the level of successfulness of simulation projects from various perspectives. They are linked to a set of Critical Success Factors (CSF) as reported in the simulation literature. A single measure called Project’s Success Measure (PSM), which represents the project’s total success level, is proposed. The framework is tested against 9 simulation exemplar cases in healthcare and this provides support for its reliability. The results suggest that responsiveness to the customer’s needs and expectations, when compared with other factors, holds the strongest association with the overall success of simulation projects. The findings highlight some patterns about the significance of individual CSFs, and how the KPIs are used to identify problem areas in simulation projects.This study was supported by the Multidisciplinar Assessment of Technology Centre for Healthcare (MATCH) program (EPSRC Grant EP/F063822/1)

Hepatocellular carcinoma: Review of disease and tumor biomarkers.

© The Author(s) 2016.Hepatocellular carcinoma (HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative treatments is limited to early stage cancers, diagnosis in non-symptomatic individuals is crucial. International guidelines advise regular surveillance of high-risk populations but the current tools lack sufficient sensitivity for early stage tumors on the background of a cirrhotic nodular liver. A number of novel biomarkers have now been suggested in the literature, which may reinforce the current surveillance methods. In addition, recent metabonomic and proteomic discoveries have established specific metabolite expressions in HCC, according to Warburgs phenomenon of altered energy metabolism. With clinical validation, a simple and non-invasive test from the serum or urine may be performed to diagnose HCC, particularly benefiting low resource regions where the burden of HCC is highest

The Relationship Between Multicast Applications and Scatter/Gather I/O

Perfect algorithms and e-business have garnered great interest from both security experts and cyberneticists in the last several years. Given the trends in authenticated technology, programmers dubiously note the intuitive unification of I/O automata and linked lists. We introduce new robust configurations (Amass), arguing that thin clients and expert systems can interact to achieve this purpose

A Bestiary of Higher Dimensional Taub-NUT-AdS Spacetimes

We present a menagerie of solutions to the vacuum Einstein equations in six, eight and ten dimensions. These solutions describe spacetimes which are either locally asymptotically adS or locally asymptotically flat, and which have non-trivial topology. We discuss the global structure of these solutions, and their relevance within the context of M-theory.Comment: 11 pages, LaTex(v4: Comments and references added

STIS Longslit Spectroscopy Of The Narrow Line Region Of NGC 4151. I. Kinematics and Emission Line Ratios

Longslit spectra of the Seyfert galaxy NGC 4151 from the UV to near infrared have been obtained with STIS to study the kinematics and physical conditions in the NLR. The kinematics show evidence for three components, a low velocity system in normal disk rotation, a high velocity system in radial outflow at a few hundred km/s relative to the systemic velocity and an additional high velocity system also in outflow with velocities up to 1400 km/s, in agreement with results from STIS slitless spectroscopy (Hutchings et al., 1998, Kaiser et al., 1999, Hutchings et al., 1999) We have explored two simple kinematic models and suggest that radial outflow in the form of a wind is the most likely explanation. We also present evidence indicating that the wind may be decelerating with distance from the nucleus. We find that the emission line ratios along our slits are all entirely consistent with photoionization from the nuclear continuum source. A decrease in the [OIII]5007/H-beta and [OIII]5007/[OII]3727 ratios suggests that the density decreases with distance from the nucleus. This trend is borne out by the [SII] ratios as well. We find no strong evidence for interaction between the radio jet and the NLR gas in either the kinematics or the emission line ratios in agreement with the results of Kaiser et al. (1999) who find no spatial coincidence of NLR clouds and knots in the radio jet. These results are in contrast to other recent studies of nearby AGN which find evidence for significant interaction between the radio source and the NLR gas.Comment: 32 pages, 13 figures, accepted for publication in The Astrophysical Journa

Phylogenetic relationships of African Caecilians (Amphibia: Gymnophiona): insights from mitochondrial rRNA gene sequences

Africa (excluding the Seychelles) has a diverse caecilian fauna, including the endemic family Scolecomorphidae and six endemic genera of the more cosmopolitan Caeciliidae. Previous molecular phylogenetic studies have not included any caecilians from the African mainland. Partial 12S and 16S mitochondrial gene sequences were obtained for two species of the endemic African Scolecomorphidae and five species and four genera of African Caeciliids, aligned against previously reported sequences for 16 caecilian species, and analysed using parsimony, maximum likelihood, Bayesian and distance methods. Results are in agreement with traditional taxonomy in providing support for the monophyly of the African Caeciliid genera Boulengerula and Schistometopum and for the Scolecomorphidae. They disagree in indicating that the Caeciliidae is paraphyletic with respect to the Scolecomorphidae. Although more data from morphology and/or molecules will be required to resolve details of the interrelationships of the African caecilian genera, the data provide strong support for at least two origins of caecilians in which the eye is reduced and covered with bone, and do not support the hypotheses that the caecilian assemblages of Africa, and of East and of West Africa are monophyletic