The Impact of the Christian Faith on Library Service

The library profession is in flux and uncertainty due to its lack of a well-founded philosophy of service. The Christian faith provides the necessary philosophical framework. Three implications follow from the application of a Christian worldview to library practice. First, Christian librarians should provide access to collections that will allow students to integrate faith and learning. Second, they should demonstrate love and concern for library users by offering diligent, humble service.Third, they should teach students the ethical use of information resources. Christianity has an impact on “library service” in three areas. First, the word library presumes a collection of library materials: books, periodicals, microfilms, motion pictures, cassettes, records, and other forms of media. Second, the word service signifies the way the librarian goes about helping people find answers to their information needs.Third, correct use of library resources connotes proper library ethics. Before this paper discusses these three areas, it will be useful to survey the current state of library philosophy

Impacts of florfenicol on the microbiota landscape and resistome as revealed by metagenomic analysis.

BACKGROUND:Drug-resistant fish pathogens can cause significant economic loss to fish farmers. Since 2012, florfenicol has become an approved drug for treating both septicemia and columnaris diseases in freshwater fish. Due to the limited drug options available for aquaculture, the impact of the therapeutical florfenicol treatment on the microbiota landscape as well as the resistome present in the aquaculture farm environment needs to be evaluated. RESULTS:Time-series metagenomic analyses were conducted to the aquatic microbiota present in the tank-based catfish production systems, in which catfish received standard therapeutic 10-day florfenicol treatment following the federal veterinary regulations. Results showed that the florfenicol treatment shifted the structure of the microbiota and reduced the biodiversity of it by acting as a strong stressor. Planctomycetes, Chloroflexi, and 13 other phyla were susceptible to the florfenicol treatment and their abundance was inhibited by the treatment. In contrast, the abundance of several bacteria belonging to the Proteobacteria, Bacteroidetes, Actinobacteria, and Verrucomicrobia phyla increased. These bacteria with increased abundance either harbor florfenicol-resistant genes (FRGs) or had beneficial mutations. The florfenicol treatment promoted the proliferation of florfenicol-resistant genes. The copy number of phenicol-specific resistance genes as well as multiple classes of antibiotic-resistant genes (ARGs) exhibited strong correlations across different genetic exchange communities (p < 0.05), indicating the horizontal transfer of florfenicol-resistant genes among these bacterial species or genera. Florfenicol treatment also induced mutation-driven resistance. Significant changes in single-nucleotide polymorphism (SNP) allele frequencies were observed in membrane transporters, genes involved in recombination, and in genes with primary functions of a resistance phenotype. CONCLUSIONS:The therapeutical level of florfenicol treatment significantly altered the microbiome and resistome present in catfish tanks. Both intra-population and inter-population horizontal ARG transfer was observed, with the intra-population transfer being more common. The oxazolidinone/phenicol-resistant gene optrA was the most prevalent transferred ARG. In addition to horizontal gene transfer, bacteria could also acquire florfenicol resistance by regulating the innate efflux systems via mutations. The observations made by this study are of great importance for guiding the strategic use of florfenicol, thus preventing the formation, persistence, and spreading of florfenicol-resistant bacteria and resistance genes in aquaculture

Novel Si(1-x)Ge(x)/Si heterojunction internal photoemission long wavelength infrared detectors

There is a major need for long-wavelength-infrared (LWIR) detector arrays in the range of 8 to 16 microns which operate with close-cycle cryocoolers above 65 K. In addition, it would be very attractive to have Si-based infrared (IR) detectors that can be easily integrated with Si readout circuitry and have good pixel-to-pixel uniformity, which is critical for focal plane array (FPA) applications. Here, researchers report a novel Si(1-x)Ge(x)/Si heterojunction internal photoemission (HIP) detector approach with a tailorable long wavelength infrared cutoff wavelength, based on internal photoemission over the Si(1-x)Ge(x)/Si heterojunction. The HIP detectors were grown by molecular beam epitaxy (MBE), which allows one to optimize the device structure with precise control of doping profiles, layer thickness and composition. The feasibility of a novel Si(1-x)Ge(x)/Si HIP detector has been demonstrated with tailorable cutoff wavelength in the LWIR region. Photoresponse at wavelengths 2 to 10 microns are obtained with quantum efficiency (QE) above approx. 1 percent in these non-optimized device structures. It should be possible to significantly improve the QE of the HIP detectors by optimizing the thickness, composition, and doping concentration of the Si(1-x)Ge(x) layers and by configuring the detector for maximum absorption such as the use of a cavity structure. With optimization of the QE and by matching the barrier energy to the desired wavelength cutoff to minimize the thermionic current, researchers predict near background limited performance in the LWIR region with operating temperatures above 65K. Finally, with mature Si processing, the relatively simple device structure offers potential for low-cost producible arrays with excellent uniformity

Persistent topographic development along a strike-slip fault system: The Mount McKinley restraining bend

The Denali Fault is a major strike-slip fault extending from British Colombia, into western Alaska. Mount McKinley, at 6,114 m, is the highest peak in North America and is located to the south of a bend in the Denali Fault (Fig.1). To the north, at the apex of the bend in the fault, Peters Dome (3,221 m) is the highest peak and north-side peak elevations rapidly decrease moving away from the bend’s apex

The Sussex-Waterloo Scale of hypnotisability (SWASH): measuring capacity or altering conscious experience

The ability to respond to hypnotic suggestibility (hypnotisability) is a stable trait which can be measured in a standardised procedure consisting of a hypnotic induction and a series of hypnotic suggestions. The SWASH is a 10-item adaptation of an established scale, the Waterloo-Stanford Group C Scale of Hypnotic Suggestibility (WSGC). Development of the SWASH was motivated by three distinct aims: to reduce required screening time, to provide an induction which more accurately reflects current theoretical understanding and to supplement the objective scoring with experiential scoring. Screening time was reduced by shortening the induction, removing two suggestions which may cause distress (dream and age regression) and by modifications which allow administration in lecture theatres, so that more participants can be screened simultaneously. Theoretical issues were addressed by removing references to sleep, absorption and eye fixation and closure. Data from 418 participants at the University of Sussex and the Lancaster University are presented, along with data from 66 participants who completed a re-test screening. The subjective and objective scales were highly correlated. The subjective scale showed good reliability and objective scale reliability was comparable to the WSGC. The addition of subjective scale responses to the post-hypnotic suggestion (PHS) item suggested a high probability that responses to PHS are inflated in WSGC screening. The SWASH is an effective measure of hypnotisability, which reflects changes in conscious experience and presents practical and theoretical advantages over existing scales

Human cytomegalovirus pUL29/28 and pUL38 repression of p53-regulated p21CIP1 and caspase 1 promoters during infection

During infection by human cytomegalovirus (HCMV), the tumor suppressor protein p53, which promotes efficient viral gene expression, is stabilized. However, the expression of numerous p53-responsive cellular genes is not upregulated. The molecular mechanism used to manipulate the transcriptional activity of p53 during infection remains unclear. The HCMV proteins IE1, IE2, pUL44, and pUL84 likely contribute to the regulation of p53. In this study, we used a discovery-based approach to identify the protein targets of the HCMV protein pUL29/28 during infection. Previous studies have demonstrated that pUL29/28 regulates viral gene expression by interacting with the chromatin remodeling complex NuRD. Here, we observed that pUL29/28 also associates with p53, an additional deacetylase complex, and several HCMV proteins, including pUL38. We confirmed the interaction between p53 and pUL29/28 in both the presence and absence of infection. HCMV pUL29/28 with pUL38 altered the activity of the 53-regulatable p21CIP1 promoter. During infection, pUL29/28 and pUL38 contributed to the inhibition of p21CIP1 as well as caspase 1 expression. The expression of several other p53-regulating genes was not altered. Infection using a UL29-deficient virus resulted in increased p53 binding and histone H3 acetylation at the responsive promoters. Furthermore, expression of pUL29/28 and its interacting partner pUL38 contributed to an increase in the steady-state protein levels of p53. This study identified two additional HCMV proteins, pUL29/28 and pUL38, which participate in the complex regulation of p53 transcriptional activity during infection