Minecrafters: An educational model for developing collaboration

In response to significant global events such as the COVID-19 pandemic, educational environments are undergoing a fundamental transformation towards collaborative online spaces and networked learning. Networked learning includes (a) the process of learning with and through other people and resources and (b) the environment (i.e., the internet) and platforms (i.e., YouTube, websites, social media, discussion forums) that support these connections or networks (Hodgson & McConnell, 2019). This shift in how learning is done necessitates a reevaluation of pedagogical methods to foster the development of students' global skills and competencies. These competencies, as defined by the Council of Ministers of Education Canada (CMEC), are recognized as essential for individuals to not only adapt but thrive in our current and future world. This world is characterized by unprecedented simultaneous challenges, often referred to as a 'polycrisis,' and rapid advancements in artificial intelligence (A.I.) that have the potential to reshape every aspect of human existence. Therefore, it is imperative that we delve into a deeper investigation and understanding of innovative pedagogical approaches to ensure students are adequately prepared for the evolving landscape. Collaboration is arguably one of the most important of the global skills and competencies as it underpins many of the essential skills youth need to thrive in educational and non-educational settings. More specifically, collaboration underpins the type of networked learning rising in popularity in formal and informal learning settings (Bülow & Nørgård, 2021). As a result, this exploratory research focuses on Minecraft: Education Edition (M:EE) as a tool for developing collaboration through critical making and team-based learning. Over a five-day spring-break camp, two cohorts of students (grades four to six and grades seven to eight) participated in open-ended design-based learning challenges online (in the virtual meeting platform, Google Meet, and in the virtual world, M:EE). Data analysis revealed that collaboration manifested itself in three primary modes: co-constructing knowledge, peer-teaching, and conflict management. Analysis further revealed that younger versus older students build and collaborate in the online environment very differently, which at times mirrored the 'real world' classroom. These findings have implications for designing age-appropriate online learning experiences to support collaboration in a networked environment, especially within virtual simulation and creation worlds like Minecraft

Title: Implementing the National Accelerated Literacy Program in Northern Territory: Findings of survey, focus groups and observations of teaching practice

Abstract This is the first of two papers on outcomes of the evaluation of the National Accelerated Literacy Program (NALP) in the NT. NALP was an attempt to rapidly improve literacy outcomes for Indigenous students in 100 schools in the Northern Territory by implementing a method of teaching known as Accelerated Literacy (AL). The authors present findings of the evaluation of the implementation of NALP (2006)(2007)(2008), focusing on the degree to which the implementation program was effective in changing teaching practices according to the requirements of the Accelerated Literacy method. The evaluators conducted a survey of practitioners, focus group interviews with teachers and coordinators in schools and systematically observed AL teaching in 68 classrooms in 36 schools. It confirms that within four years, NALP had achieved the implementation of AL in a large number of NT schools such that teachers and principals in close to the target number of schools had been engaged in the process of change. However, notwithstanding this progress in implementation of the program in NT schools, the results of this evaluation suggest that by early 2008 there had been uneven success in changing teacher practice to achieve the levels of teaching of AL to desired standards in classrooms. The evaluation questions whether the policy commitments were always insufficient to support and sustain the implementation of AL to appropriate levels in terms of quality and completeness of systemic support

Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic

Genome editing using clustered regularly interspersed short palindromic repeats (CRISPR) and CRISPR-associated proteins offers the potential to facilitate safe and effective treatment of genetic diseases refractory to other types of intervention. Here, we identify some of the major challenges for clinicians, regulators, and human research ethics committees in the clinical translation of CRISPR-mediated somatic cell therapy

Genome-wide association analysis identifies six new loci associated with forced vital capacity

Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 individuals from 26 studies and followed up the top associations in 32,917 additional individuals of European ancestry. We found six new regions associated at genome-wide significance (P < 5 × 10−8) with FVC in or near EFEMP1, BMP6, MIR129-2–HSD17B12, PRDM11, WWOX and KCNJ2. Two loci previously associated with spirometric measures (GSTCD and PTCH1) were related to FVC. Newly implicated regions were followed up in samples from African-American, Korean, Chinese and Hispanic individuals. We detected transcripts for all six newly implicated genes in human lung tissue. The new loci may inform mechanisms involved in lung development and the pathogenesis of restrictive lung disease

Exome-wide association study to identify rare variants influencing COVID-19 outcomes : Results from the Host Genetics Initiative

Publisher Copyright: Copyright: © 2022 Butler-Laporte et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Host genetics is a key determinant of COVID-19 outcomes. Previously, the COVID-19 Host Genetics Initiative genome-wide association study used common variants to identify multiple loci associated with COVID-19 outcomes. However, variants with the largest impact on COVID-19 outcomes are expected to be rare in the population. Hence, studying rare variants may provide additional insights into disease susceptibility and pathogenesis, thereby informing therapeutics development. Here, we combined whole-exome and whole-genome sequencing from 21 cohorts across 12 countries and performed rare variant exome-wide burden analyses for COVID-19 outcomes. In an analysis of 5,085 severe disease cases and 571,737 controls, we observed that carrying a rare deleterious variant in the SARS-CoV-2 sensor toll-like receptor TLR7 (on chromosome X) was associated with a 5.3-fold increase in severe disease (95% CI: 2.75–10.05, p = 5.41x10-7). This association was consistent across sexes. These results further support TLR7 as a genetic determinant of severe disease and suggest that larger studies on rare variants influencing COVID-19 outcomes could provide additional insights.Peer reviewe

Association of Forced Vital Capacity with the Developmental Gene <i>NCOR2</i>

Background Forced Vital Capacity (FVC) is an important predictor of all-cause mortality in the absence of chronic respiratory conditions. Epidemiological evidence highlights the role of early life factors on adult FVC, pointing to environmental exposures and genes affecting lung development as risk factors for low FVC later in life. Although highly heritable, a small number of genes have been found associated with FVC, and we aimed at identifying further genetic variants by focusing on lung development genes. Methods Per-allele effects of 24,728 SNPs in 403 genes involved in lung development were tested in 7,749 adults from three studies (NFBC1966, ECRHS, EGEA). The most significant SNP for the top 25 genes was followed-up in 46,103 adults (CHARGE and SpiroMeta consortia) and 5,062 children (ALSPAC). Associations were considered replicated if the replication p-value survived Bonferroni correction (p</p

SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues

Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component. Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci (eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene), including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types

A first update on mapping the human genetic architecture of COVID-19

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