Anomaly Inflow and Membrane Dynamics in the QCD Vacuum

Large $N_c$ and holographic arguments, as well as Monte Carlo results, suggest that the topological structure of the QCD vacuum is dominated by codimension-one membranes which appear as thin dipole layers of topological charge. Such membranes arise naturally as $D6$ branes in the holographic formulation of QCD based on IIA string theory. The polarizability of these membranes leads to a vacuum energy $\propto \theta^2$, providing the origin of nonzero topological susceptibility. Here we show that the axial U(1) anomaly can be formulated as anomaly inflow on the brane surfaces. A 4D gauge transformation at the brane surface separates into a 3D gauge transformation of components within the brane and the transformation of the transverse component. The in-brane gauge transformation induces currents of an effective Chern-Simons theory on the brane surface, while the transformation of the transverse component describes the transverse motion of the brane and is related to the Ramond-Ramond closed string field in the holographic formulation of QCD. The relation between the surface currents and the transverse motion of the brane is dictated by the descent equations of Yang-Mills theory.Comment: 22 pages, 3 figure

Star Formation, Supernovae Feedback and the Angular Momentum Problem in Numerical CDM Cosmogony: Half Way There?

We present a smoothed particle hydrodynamic (SPH) simulation that reproduces a galaxy that is a moderate facsimile of those observed. The primary failing point of previous simulations of disk formation, namely excessive transport of angular momentum from gas to dark matter, is ameliorated by the inclusion of a supernova feedback algorithm that allows energy to persist in the model ISM for a period corresponding to the lifetime of stellar associations. The inclusion of feedback leads to a disk at a redshift $z=0.52$, with a specific angular momentum content within 10% of the value required to fit observations. An exponential fit to the disk baryon surface density gives a scale length within 17% of the theoretical value. Runs without feedback, with or without star formation, exhibit the drastic angular momentum transport observed elsewhere.Comment: 4 pages, 3 figures, accepted for publication in ApJ Letter

Coherent Topological Charge Structure in CPN−1CP^{N-1} Models and QCD

In an effort to clarify the significance of the recent observation of long-range topological charge coherence in QCD gauge configurations, we study the local topological charge distributions in two-dimensional $CP^{N-1}$ sigma models, using the overlap Dirac operator to construct the lattice topological charge. We find long-range sign coherence of topological charge along extended one-dimensional structures in two-dimensional spacetime. We discuss the connection between the long range topological structure found in $CP^{N-1}$ and the observed sign coherence along three-dimensional sheets in four-dimensional QCD gauge configurations. In both cases, coherent regions of topological charge form along membrane-like surfaces of codimension one. We show that the Monte Carlo results, for both two-dimensional and four-dimensional gauge theory, support a view of topological charge fluctuations suggested by Luscher and Witten. In this framework, the observed membranes are associated with boundaries between ``k-vacua,'' characterized by an effective local value of $\theta$ which jumps by $\pm 2\pi$ across the boundary.Comment: 26 page

Randomized sham controlled trial of cranial microcurrent stimulation for symptoms of depression, anxiety, pain, fatigue and sleep disturbances in women receiving chemotherapy for early-stage breast cancer

Purpose Women with breast cancer may experience symptoms of depression, anxiety, pain, fatigue and sleep disturbances during chemotherapy. However, there are few modalities that address multiple, commonly occurring symptoms that may occur in individuals receiving cancer treatment. Cranial electrical stimulation (CES) is a treatment that is FDA cleared for depression, anxiety and insomnia. CES is applied via electrodes placed on the ear that deliver pulsed, low amplitude electrical current to the head. Methods This phase III randomized, sham-controlled study aimed to examine the effects of cranial microcurrent stimulation on symptoms of depression, anxiety, pain, fatigue, and sleep disturbances in women receiving chemotherapy for early-stage breast cancer. Patients were randomly assigned to either an actual or sham device and used the device daily for 1 h. The study was registered at clinicaltrials.gov, NCT00902330. Results The sample included N = 167 women with early-stage breast cancer. Symptom severity of depression, anxiety, and fatigue and sleep disturbances were generally mild to moderate. Levels of pain were low. Anxiety was highest prior to the initial chemotherapy and decreased over time. The primary outcome assessment (symptoms of depression, anxiety, fatigue, pain, sleep disturbances) revealed no statistically significant differences between the two groups, actual CES vs. sham. Conclusion In this study, women receiving chemotherapy for breast cancer experienced multiple symptoms in the mild to moderate range. Although there is no evidence for the routine use of CES during the chemotherapy period for symptom management in women with breast cancer, further symptom management modalities should be evaluated to mitigate symptoms of depression, anxiety, fatigue, pain and sleep disturbances over the course of chemotherapy

Hemostasis biomarkers and incident cognitive impairment: the REGARDS study

Essentials Cognitive disorders are increasing and vascular risk factors play a role in this. We performed a nested case control study of hemostasis biomarkers and cognitive impairment (CI). Higher baseline fibrinogen, factor VIII and D-dimer were related to incident CI over 3.5 years. Adjusted for other risk factors, 2+ abnormal markers (but not single ones) led to higher risk. SUMMARY: Background Vascular risk factors are associated with cognitive impairment, a condition that imposes a substantial public health burden. We hypothesized that hemostasis biomarkers related to vascular disease would be associated with the risk of incident cognitive impairment. Methods We performed a nested case-control study including 1082 participants with 3.5 years of follow-up in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study, a longitudinal cohort study of 30 239 black and white Americans aged ≥ 45 years. Participants were free of stroke or cognitive impairment at baseline. Baseline D-dimer, fibrinogen, factor VIII and protein C levels were measured in 495 cases who developed cognitive impairment during follow-up (based on abnormal scores on two or more of three cognitive tests) and 587 controls. Results Unadjusted odds ratios (ORs) for incident cognitive impairment were 1.32 (95% confidence interval [CI] 1.02-1.70) for D-dimer > 0.50 μg mL-1 , 1.83 (95% CI 1.24-2.71) for fibrinogen > 90th percentile, 1.63 (95% CI 1.11-2.38) for FVIII > 90th percentile, and 1.10 (95% CI 0.73-1.65) for protein C < 10th percentile. There were no differences in associations by race or region. Adjustment for demographic, vascular and health behavior risk factors attenuated these associations. However, having at least two elevated biomarkers was associated with incident cognitive impairment, with an adjusted OR of 1.73 (95% CI 1.10-2.69). Conclusion Elevated D-dimer, fibrinogen and FVIII levels were not associated with the occurrence of cognitive impairment after multivariable adjustment; however, having at least two abnormal biomarkers was associated with the occurrence of cognitive impairment, suggesting that the burden of these biomarkers is relevant

Smoothed Particle Hydrodynamics in cosmology: a comparative study of implementations

We analyse the performance of twelve different implementations of Smoothed Particle Hydrodynamics (SPH) using seven tests designed to isolate key hydrodynamic elements of cosmological simulations which are known to cause the SPH algorithm problems. In order, we consider a shock tube, spherical adiabatic collapse, cooling flow model, drag, a cosmological simulation, rotating cloud-collapse and disc stability. In the implementations special attention is given to the way in which force symmetry is enforced in the equations of motion. We study in detail how the hydrodynamics are affected by different implementations of the artificial viscosity including those with a shear-correction modification. We present an improved first-order smoothing-length update algorithm that is designed to remove instabilities that are present in the Hernquist and Katz (1989) algorithm. For all tests we find that the artificial viscosity is the most important factor distinguishing the results from the various implementations. The second most important factor is the way force symmetry is achieved in the equation of motion. Most results favour a kernel symmetrization approach. The exact method by which SPH pressure forces are included has comparatively little effect on the results. Combining the equation of motion presented in Thomas and Couchman (1992) with a modification of the Monaghan and Gingold (1983) artificial viscosity leads to an SPH scheme that is both fast and reliable.Comment: 30 pages, 26 figures and 9 tables included. Submitted to MNRAS. Postscript version available at ftp://phobos.astro.uwo.ca/pub/etittley/papers/sphtest.ps.g

Orthopedic management of the extremities in patients with Morquio A syndrome.

BackgroundMusculoskeletal involvement in Morquio A syndrome (mucopolysaccharidosis IVA; MPS IVA) contributes significantly to morbidity and mortality. While the spinal manifestations of the disorder have received considerable attention in the literature, there have been few reported studies to date to guide the management of the orthopedic problems associated with the lower and upper extremities.PurposeThe objective was to develop recommendations for the management of the extremities in patients with Morquio A syndrome.MethodsA group of specialists in orthopedics, pediatrics and genetics with experience in the management of Morquio A patients convened to review and discuss current clinical practices and to develop preliminary recommendations. Evidence from the literature was retrieved. Recommendations were further refined until consensus was reached.Results and conclusionsThis present article provides a detailed review and discussion of the lower and upper extremity deformities in Morquio A syndrome and presents recommendations for the assessment and treatment of these complications. Key issues, including the importance of early diagnosis and the implications of medical therapy, are also addressed. The recommendations herein represent an attempt to develop a uniform and practical approach to managing patients with Morquio A syndrome and improving their outcomes