ORegAnno 3.0: A community-driven resource for curated regulatory annotation

The Open Regulatory Annotation database (ORegAnno) is a resource for curated regulatory annotation. It contains information about regulatory regions, transcription factor binding sites, RNA binding sites, regulatory variants, haplotypes, and other regulatory elements. ORegAnno differentiates itself from other regulatory resources by facilitating crowd-sourced interpretation and annotation of regulatory observations from the literature and highly curated resources. It contains a comprehensive annotation scheme that aims to describe both the elements and outcomes of regulatory events. Moreover, ORegAnno assembles these disparate data sources and annotations into a single, high quality catalogue of curated regulatory information. The current release is an update of the database previously featured in the NAR Database Issue, and now contains 1 948 307 records, across 18 species, with a combined coverage of 334 215 080 bp. Complete records, annotation, and other associated data are available for browsing and download at http://www.oreganno.org/

A scientific methodology for researching CALL interaction data: Multimodal LEarning and TEaching Corpora

International audienceThis chapter gives an overview of one possible staged methodology for structuring LCI data by presenting a new scientific object, LEarning and TEaching Corpora (LETEC). Firstly, the chapter clarifies the notion of corpora, used in so many different ways in language studies, and underlines how corpora differ from raw language data. Secondly, using examples taken from actual online learning situations, the chapter illustrates the methodology that is used to collect, transform and organize data from online learning situations in order to make them sharable through open-access repositories. The ethics and rights for releasing a corpus as OpenData are discussed. Thirdly, the authors suggest how the transcription of interactions may become more systematic, and what benefits may be expected from analysis tools, before opening the CALL research perspective applied to LCI towards its applications to teacher-training in Computer-Mediated Communication (CMC), and the common interests the CALL field shares with researchers in the field of Corpus Linguistics working on CMC

OSI2018 SUMMARY REPORT on the 1st Summit Meeting of the Global Open Scholarship Initiative, March 12-14, 2018

When the roadmap for OSI was first being developed in 2015, our original intent was to hold a series of 10 annual meetings beginning in 2016. After the first two meetings, however, it became apparent that the next step in this process should be to pause and have just the summit group meet to formally discuss and plan out what comes next instead of having this complex conversation online (which we had been doing since mid-2017) or amongst a group of several hundred participants. This decision was also necessitated by the lack of a large enough budget to put together another full-group meeting for 2018. The full OSI summit group currently consists of 35 members appointed by the OSI program director to represent all 18 stakeholder groups by quota (see Annex section for details). Eighteen members of this group met in person at American University in Washington DC on March 12-14, 2018. In attendance were Bryan Alexander, Rick Anderson, Kim Barrett, Nancy Davenport, Joann Delenick (virtual attendee), Mel DeSart, Chris Erdman, Glenn Hampson (ex officio), Patrick Herron, Gemma Hersh, Claudia Holland, Bhanu Neupane, Joyce Ogburn, Eric Olson, Abel Packer, T Scott Plutchak (interim Summit chair), Wim van der Steldt, and John Warren. The American University was our host for this event, providing meeting space, IT support and catering. Many thanks to American University Librarian Nancy Davenport and her team for coordinating this effort and making this important meeting possible. The overall goal of this first in-person meeting of the summit group was to discuss and formally approve detailed action plans for the coming months as OSI shifts from an information gathering mode to a more action oriented one. Many fundamental questions were also discussed. This was OSI’s first extended opportunity to really debate perspectives on OSI’s reason for being, what we hope to accomplish, and how. To this point, the answers to these questions have all been debated online or imposed on this group. This was our first opportunity, other than in email conversations, to really dig deeper and wrestle with the realpolitik of what OSI plans to accomplish

Come to the Great Hall at One! Save the 3000 Students and 100 Instructors Facing Ouster! Fight Fees! Demand Free Books!

Flyer for political rally on October 2, 1934. Student Publications: The Campus Newspaper Collectio

Topic 4: Institutional repository success is dependent upon mandates

No Abstract.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/62145/1/1720350410_ftp.pd

Geoscience after IT: Part L. Adjusting the emerging information system to new technology

Coherent development depends on following widely used standards that respect our vast legacy of existing entries in the geoscience record. Middleware ensures that we see a coherent view from our desktops of diverse sources of information. Developments specific to managing the written word, map content, and structured data come together in shared metadata linking topics and information types

Pre-operative oral nutritional supplementation with dietary advice versus dietary advice alone in weight-losing patients with colorectal cancer: single-blind randomized controlled trial.

BACKGROUND: Pre-operative weight loss has been consistently associated with increased post-operative morbidity. The study aims to determine if pre-operative oral nutritional supplements (ONSs) with dietary advice reduce post-operative complications. METHODS: Single-blinded randomized controlled trial. People with colorectal cancer scheduled for surgery with pre-operative weight loss >1 kg/3-6 months were randomized by using stratified blocks (1:1 ratio) in six hospitals (1 November 2013-28 February 2015). Intervention group was given 250 mL/day ONS (10.1 KJ and 0.096 g protein per mL) and dietary advice. Control group received dietary advice alone. Oral nutritional supplements were administered from diagnosis to the day preceding surgery. Research team was masked to group allocation. Primary outcome was patients with one or more surgical site infection (SSI) or chest infection; secondary outcomes included percentage weight loss, total complications, and body composition measurements. Intention-to-treat analysis was performed with both unadjusted and adjusted analyses. A sample size of 88 was required. RESULTS: Of 101 participants, (55 ONS, 46 controls) 97 had surgery. In intention-to-treat analysis, there were 21/45 (47%) patients with an infection-either an SSI or chest infection in the control group vs. 17/55 (30%) in the ONS group. The odds ratio of a patient incurring either an SSI or chest infection was 0.532 (P = 0.135 confidence interval 0.232 to 1.218) in the unadjusted analysis and when adjusted for random differences at baseline (age, gender, percentage weight loss, and cancer staging) was 0.341 (P = 0.031, confidence interval 0.128 to 0.909). Pre-operative percentage weight loss at the first time point after randomization was 4.1% [interquartile range (IQR) 1.7-7.0] in ONS group vs. 6.7% (IQR 2.6-10.8) in controls (Mann-Whitney U P = 0.021) and post-operatively was 7.4% (IQR 4.3-10.0) in ONS group vs. 10.2% (IQR 5.1-18.5) in controls (P = 0.016). CONCLUSIONS: Compared with dietary advice alone, ONS resulted in patients having fewer infections and less weight loss following surgery for colorectal cancer. We have demonstrated that pre-operative oral nutritional supplementation can improve clinical outcome in weight losing patients with colorectal cancer

Identity and difference - re-thinking UK South Asian entrepreneurship

Purpose: This paper, which is part of a larger study, discusses from an ethno-cultural perspective, the notion of self-identification and difference pertaining to first and second-generation South Asian male entrepreneurs. In essence, previous studies have not explored this dimension to any sufficient depth. Therefore, evidence is unclear as to how ethno-culture has informed entrepreneurial identity and difference. Design/methodology/approach: Adopting a phenomenological research paradigm, 42 semi-structured interviews were conducted with first and second-generation Sikh and Pakistani Muslim male entrepreneurs in Greater London. A typology of second-generation entrepreneurs is developed and a research agenda proposed. Findings: First-generation respondents regard the UK as home, and do not suffer from shifts in identity. These particular respondents identify themselves as Sikh, or Pakistani Muslim, or a Businessman. However, the second-generation identify themselves via three distinct labels. Here respondents stress their ethnicity by using Hyphenated British identities, or hide their ethnicity behind the term a Normal Businessman, or appear opportunists by using ethnicity as a resource to espouse a True Entrepreneurial identity. Research limitations/implications: The research environment within the Greater London area where the respondents are located may not be as generalisible when compared with other parts of the UK. Originality/value: This paper offers a unique insight into self-prescribed identity and difference noted among London’s ethnic entrepreneurs

The 'lost child' as figure of trauma and recovery in early post-war cinema: Fred Zinnemann's The Search (1948) and Natan Gross's Unzere Kinder (1948)

The article examines the figure of the ‘lost child’ in feature films of the immediate post-war period. The figure’s enormous symbolic value as innocent victim and future generation, granted the ‘lost child’ a key position in post-war discourse, including films which tried to grapple with the moral and physical destruction of the continent after 1945. National film industries, particularly of the perpetrator nation, employed the ‘lost child’ for genre stories in which the post-war chaos is being mastered and a new, masculine national self is re-built. However, films made by victim groups outside a national context rely on the ‘lost child’ to broach the destruction of their identity by war and persecution. Analysing two films, Fred Zinnemann’s The Search (1948) and Nata Gross’s Unzere Kinder (1948), I argue that they use the child figure to deal with traumatization and make it part of the reconstruction of communal intergenerational relations. This does not result in stories of masculine mastery but in narratives that incorporate moments of trauma process emerging around destroyed mother-child relations. The films, encoding traumatization in film language, develop a rich cinematic language along questions of identity and form a first instance of posttraumatic cinema