Accuracy of Wrist-worn Physical Activity Monitors to Measure Energy Expenditure

IIn recent years, the popularity and demand of physical activity monitors has drastically risen with the need and want to improve physical fitness. Newer devices worn on the wrist measure both heart rate and energy expenditure but the accuracy of these measurements is unclear. PURPOSE: To measure the accuracy of three separate wrist-worn activity monitors to estimate energy expenditure during structured periods of aerobic exercise. METHODS: Twelve men and three women (22 ± 3 years, 25 ± 3 kg/m2) consented to participate in this study. Three different physical activity monitors, TomTom Cardio (TT), Microsoft Band (MB), and Fitbit Surge (FB), were randomly assigned to either the left or right wrist of each participant. The instructions for the testing procedure were thoroughly explained to every participant at the start of each trial. The treadmill started at a speed of 2 mph and increased by 1 mph every three minutes up to a max speed of 6 mph. Energy expenditure was estimated through direct measurement of oxygen consumed and carbon dioxide produced through a metabolic cart (MC, Parvo Medics True One ®2400). The mean bias in energy expenditure between MC and each device was calculated. Pearson product-moment correlations and 95% equivalence testing were also calculated. Statistical significance was set at an alpha level of 0.05. RESULTS: The mean bias between the MC and devices at 2 mph varied from -1.9 ± 1.1 kcal/min (FB) to 0.7 ± 1.0 kcal/min (MB) while the mean bias at 6 mph varied from -1.7 ± 2.1 kcal/min (MB) to 5.2 ± 1.7 kcal/min (TT). For total energy expenditure, all devices were significantly correlated with the MC (FB: r=0.66, p=0.007; TomTom: r=0.77, p\u3c0.001; MB: r=0.59, p=0.02). The mean bias for total energy expenditure was -25 ± 16 kcal for the FB, 26 ± 13 kcal for the TT, and -11 ± 17 kcal for the MB. The equivalence zone for MC was 88 kcal to 108 kcal but 90% confidence intervals of devices did not fall within this zone. CONCLUSION: The wrist-worn physical activity monitors used in this study that measure heart rate and energy expenditure tend to either underestimate or overestimate total energy expenditure from treadmill walking and running

Validity of Wrist-worn Physical Activity Monitors to Measure Heart Rate

Numerous physical activity monitors exist and are used to track and improve fitness levels. Due to the increasing popularity of these devices, newer products have been developed that measure heart rate (HR) at the wrist. Little is known about how accurate these devices are at measuring HR at the wrist and how they compare to each other. PURPOSE: To determine how accurately HR was measured by three different wrist-worn physical activity monitors. METHODS: Recreationally active men (n=9) and women (n=3) participated in this study. The average age and weight of participants was 22 ± 3 years and 73.9 ± 12 kg. TomTom Cardio (TT), Fitbit Surge (FB) and Microsoft Band (MB) physical activity monitors were used. The TT, FB, and MB were randomly assigned to the right or left wrist for each participant. The testing procedure included speeds of 2, 3, 4, 5, and 6 mph with each speed lasting three minutes. HR was measured by electrocardiography (ECG) using standard limb lead II and by the three different physical activity monitors. HR was recorded from each device every minute throughout the duration of the procedure. Pearson product moment correlations and bias between electrocardiography (ECG) and physical activity monitors with 95% limits of agreement (Bland-Altman analysis) were calculated. Repeated measures ANOVA [Speed x Device] were also calculated. Statistical significance was set at pRESULTS: At 2 mph and 3 mph, only TT HR was significantly correlated with ECG heart rate (r=0.693, p=0.012 and r=0.592, p=0.043). At 4 mph and 6 mph TT was significantly correlated with ECG (r=0.911, pCONCLUSION: With increasing speeds, physical activity monitors more accurately measure HR but individuals should be aware that these devices may overestimate HR during slower walking speeds

The Influence of Aging on Cardiovascular Measures After an Acute Bout of Resistance Exercise

As individuals age, substantial physiological changes occur. Most notably there is a decrease in muscle mass known as sarcopenia and an increase in arterial stiffness. In order to attenuate declines in muscle mass, resistance training effectively improves both muscle size and strength of older individuals. However, the effects of resistance training on the arterial system are less clear with studies noting increased, decreased, and no change in arterial stiffness after resistance training. Purpose: The purpose of this study was to determine how aging affected arterial stiffness and other cardiovascular measure responses to a whole body resistance training session. Methods: Thirty-six men were separated into three groups based on age (Young-aged, YG: 20-39 years; middle-aged, MG: 40-59 years; older-aged, OG: 60-75 years). A randomized controlled cross-over design was used. During one condition, participants rested for 30 minutes and in the other condition, participants performed whole-body resistance exercise consisting of leg press, bench press, knee flexion, lat pulldown and knee extension (3 sets of 10 reps at 65% one-repetition maximum for each exercise). Blood pressure, augmentation pressure, augmentation index, peripheral pulse wave velocity, central pulse wave velocity, heart function, and forearm blood flow were measured before and after each condition. Change scores from pre to post time points were used for analysis. Two-way repeated measures ANOVA was used to determine differences between conditions (exercise vs. control) and groups (YG vs. MG vs. OG). Statistical significance was set at p≤0.05. Results: No differences were found between age groups for blood pressure responses. When groups were combined, peripheral systolic blood pressure significantly increased after exercise when compared to the control condition (6 ± 7 vs. 1 ± 6 mmHg, p=0.003). Also, peripheral (-5 ± 6 vs. 2 ± 4 mmHg, p<0.001) and central diastolic blood pressures (-4 ± 6 vs. 2 ± 4 mmHg, p<0.001) significantly decreased when compared to the control condition. Augmentation index significantly increased after exercise when compared to the control condition for the YG (11 ± 8 vs. 0 ± 7%, p<0.001) but not for the MG (-1 ± 8 vs. -1 ± 5%, p=0.788) or OG (-3 ± 7 vs. 2 ± 4%, p=0.076). However, no significant changes were found for central pulse wave velocity. Heart function was also not altered substantially between age groups after exercise. Conclusion: It appears that some cardiovascular variables are affected more by aging than others after performing resistance exercise. Most notably, augmentation index is significantly elevated after resistance exercise in younger individuals but not in middle-aged and older-aged individuals when compared to a control condition. However, no significant increases were noted for central pulse wave velocity for any age group. Therefore, moderate resistance training does not appear to result in acute prolonged increases in arterial stiffness in middle-aged and older-aged adults

The Effects of Virtual Group Study on Class Views and Performance

Peer-to-peer teaching improves academic performance. During the worldwide pandemic, peer-to-peer teaching was unavailable, and feelings of isolation and loneliness increased. This study investigated the impact of virtual peer-to-peer group study on student performance and class views in a virtual, undergraduate exercise physiology course. Sixty-nine college-aged adults were randomly assigned to study with a virtual group or individually for two instructional units. Students switched groups after the first unit. For virtual group study, students met virtually for at least one hour outside of class to study course content. Those assigned to the individual study did not study virtually with classmates. Unit exams were given after each instructional unit. Mann-Whitney tests were used to evaluate study group differences on class performance. Class views were assessed using seven-point Likert scales and Wilcoxon signed-ranked tests. Exam scores were not significantly different between the virtual group study and individual study for exam 1 (72.3 ± 8.6% vs. 70.4 ± 13.3%, p =0.824) or for exam 2 (68.5 ± 14.5% vs. 67 ± 13.5%, p = 0.782). Virtual group study led to more class connection (2.4 ± 1.3 vs 5.1 ± 1.6; p \u3c 0.001) and focus (2.05 ± 1.11 vs 2.94 ± 1.23; p \u3c 0.001) than individual study. Virtual group study, outside of class, had a significant effect on in-class connection and outside-of-class study focus without reducing class performance. Virtual group study may be an effective tool to help students connect out of class when other meeting options are not available

To play or not to play: Can an instrument really impact lip and tongue performance?

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. (1) Background: Increasing tongue and lip strength may help improve various speech and swallowing disorders, but it is unclear if instrumentalists who use these muscle groups for long periods of time have greater strength and endurance compared to controls. It is also unclear if instrumentalists can more accurately estimate various exercise intensities. The purpose of this study was to determine differences in lip and tongue strength and endurance between instrumentalists and non-instrumentalists (controls). A secondary purpose was to assess differences in ability to estimate various exercise intensities between the two groups. (2) Methods: Instrumentalists and controls’ maximum strength and endurance were measured using the IOPI Pro medical device. In addition, 40%, 60% and 80% of maximum strength were estimated in a randomized order. (3) Results: No significant differences were found between instrumentalists and controls in strength or endurance or the ability to estimate various intensities. Overall, participants were better at estimating tongue strength at moderate intensities and lip strength at higher intensities. (4) Conclusion: Tongue and lip strength and endurance and the ability to estimate exercise intensities are not impacted by years of instrumentalist training compared to healthy controls

Genetic variation and exercise-induced muscle damage: implications for athletic performance, injury and ageing.

Prolonged unaccustomed exercise involving muscle lengthening (eccentric) actions can result in ultrastructural muscle disruption, impaired excitation-contraction coupling, inflammation and muscle protein degradation. This process is associated with delayed onset muscle soreness and is referred to as exercise-induced muscle damage. Although a certain amount of muscle damage may be necessary for adaptation to occur, excessive damage or inadequate recovery from exercise-induced muscle damage can increase injury risk, particularly in older individuals, who experience more damage and require longer to recover from muscle damaging exercise than younger adults. Furthermore, it is apparent that inter-individual variation exists in the response to exercise-induced muscle damage, and there is evidence that genetic variability may play a key role. Although this area of research is in its infancy, certain gene variations, or polymorphisms have been associated with exercise-induced muscle damage (i.e. individuals with certain genotypes experience greater muscle damage, and require longer recovery, following strenuous exercise). These polymorphisms include ACTN3 (R577X, rs1815739), TNF (-308 G>A, rs1800629), IL6 (-174 G>C, rs1800795), and IGF2 (ApaI, 17200 G>A, rs680). Knowing how someone is likely to respond to a particular type of exercise could help coaches/practitioners individualise the exercise training of their athletes/patients, thus maximising recovery and adaptation, while reducing overload-associated injury risk. The purpose of this review is to provide a critical analysis of the literature concerning gene polymorphisms associated with exercise-induced muscle damage, both in young and older individuals, and to highlight the potential mechanisms underpinning these associations, thus providing a better understanding of exercise-induced muscle damage

Effects of Blood Flow Restricted Low-Intensity Concentric or Eccentric Training on Muscle Size and Strength

The authors thank the students who participated in this study. We also thank Toshiaki Nakajima, MD, PhD, Ken Masamune, PhD, Hiroki Kamiuchi, The University of Tokyo, for helpful discussion and technical support.Conceived and designed the experiments: TY TA. Performed the experiments: TY. Analyzed the data: TY JPL TA. Wrote the paper: TY JPL RST TA.We investigated the acute and chronic effects of low-intensity concentric or eccentric resistance training with blood flow restriction (BFR) on muscle size and strength. Ten young men performed 30% of concentric one repetition maximal dumbbell curl exercise (four sets, total 75 reps) 3 days/week for 6 weeks. One arm was randomly chosen for concentric BFR (CON-BFR) exercise only and the other arm performed eccentric BFR (ECC-BFR) exercise only at the same exercise load. During the exercise session, iEMG for biceps brachii muscles increased progressively during CON-BFR, which was greater (p<0.05) than that of the ECC-BFR. Immediately after the exercise, muscle thickness (MTH) of the elbow flexors acutely increased (p<0.01) with both CON-BFR and ECC-BFR, but was greater with CON-BFR (11.7%) (p<0.01) than ECC-BFR (3.9%) at 10-cm above the elbow joint. Following 6-weeks of training, MRI-measured muscle cross-sectional area (CSA) at 10-cm position and mid-upper arm (12.0% and 10.6%, respectively) as well as muscle volume (12.5%) of the elbow flexors were increased (p<0.01) with CON-BFR. Increases in muscle CSA and volume were lower in ECC-BFR (5.1%, 0.8% and 2.9%, respectively) than in the CON-BFR and only muscle CSA at 10-cm position increased significantly (p<0.05) after the training. Maximal voluntary isometric strength of elbow flexors was increased (p<0.05) in CON-BFR (8.6%), but not in ECC (3.8%). These results suggest that CON-BFR training leads to pronounced acute changes in muscle size, an index of muscle cell swelling, the response to which may be an important factor for promoting muscle hypertrophy with BFR resistance training.Yeshttp://www.plosone.org/static/editorial#pee

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

Background: We previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15–20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in ~ 80% of cases. Methods: We report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded. Results: No gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5–528.7, P = 1.1 × 10−4) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR = 3.70[95%CI 1.3–8.2], P = 2.1 × 10−4). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR = 19.65[95%CI 2.1–2635.4], P = 3.4 × 10−3), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR = 4.40[9%CI 2.3–8.4], P = 7.7 × 10−8). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD] = 43.3 [20.3] years) than the other patients (56.0 [17.3] years; P = 1.68 × 10−5). Conclusions: Rare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60&nbsp;years old