Discourse in a material world

We challenge recent assertions that discourse studies cannot de facto address materiality. We demonstrate how a Foucauldian theorization of discourse provides a way to analyse the co‐constitutive nature of discursive and material processes, as well as explore the power relations implicated in these relationships. To illustrate our argument, we identify exemplary studies that have effectively combined a study of discourse and different aspects of materiality – bodies, objects, spaces, and practices. In doing so, we show how discourse scholars are able to study both materiality and power relations

Concepts for autonomous flight control for a balloon on Mars

Balloons operating as airborne rovers have been suggested as ideal candidates for early exploration of the Martian surface. An international study team composed of scientists from the U.S.S.R., France, and the U.S.A. is planning the launching in 1994 of a balloon system to fly on Mars. The current likely design is a dual thermal/gas balloon that consists of a gas balloon suspended above a solar-heated thermal balloon. At night, the thermal balloon provides no lift, and the balloon system drifts just above the Martian surface; the lift of the gas balloon is just sufficient to prevent the science payload from hitting the ground. During the day, the balloon system flies at an altitude of 4 to 5 kilometers, rising due to the added lift provided by the thermal balloon. Over the course of a single Martian day, there may be winds in several directions, and in fact it can be expected that there will be winds simultaneously in different directions at different altitudes. Therefore, a balloon system capable of controlling its own altitude, via an autonomous flight control system, can take advantage of these different winds to control its direction, thereby greatly increasing both its mission utility and its longevity

What's age got to do with it? On the critical analysis of age and organisations

Age, as an embodied identity and as an organizing principle, has received scant attention in organization studies. There is a lack of critical appreciation of how age plays out in organizational settings, the material and discursive dynamics of age practices, how age discourses impact on the body, and how age and ageing intersect with other identity categories. This is curious since age works as a master signifier in contemporary society and is something that affects us all. In this introductory essay, we show how the papers in this special issue redress this lacuna by enhancing and challenging what we know about age and organizations. We also set out an agenda for stimulating research conversations to bring an age-sensitive lens to organizational analysis. We structure our analysis around two focal points: age as an embodied identity, and the symbolic meanings of age within organizing practices. In doing so, we aim to provide a catalyst not only for research on age in organizations but also about the aged nature of organizing

Downstream benefits vs upstream costs of land use change for water-yield and salt-load targets in the Macquarie Catchment, NSW

The net present value (NPV) of downstream economic benefits of changes in water-yield (W) and salt-load (S) of mean annual river flow received by a lower catchment from an upper catchment are described as a 3-dimensional (NPV,W, S) surface, where dNPV/dW > 0 and dNPV/d(S/W) < 0. Upstream changes in land use (i.e. forest clearing or forest establishment, which result in higher or lower water-yields, respectively) are driven by economic consequences for land owners. This paper defines conditions under which costs of strategic upstream land use changes could be exceeded by compensations afforded by downstream benefits from altered water-yields and/or lower salt loads. The paper presents methods, and preliminary calculations for an example river, quantifying the scope for such combinations, and raising the question of institutional designs to achieve mutually beneficial upstream and downstream outcomes. Examples refer to the Macquarie River downstream of Dubbo, NSW, and Little River, an upstream tributary.policy, markets, upstream, downstream, water, salinity, Land Economics/Use,

RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca2+ assays.

Elevated cytoplasmic [Ca2+] is characteristic in severe skeletal and cardiac myopathies, diabetes, and neurodegeneration, and partly results from increased Ca2+ leak from sarcoplasmic reticulum stores via dysregulated ryanodine receptor (RyR) channels. Consequently, RyR is recognized as a high-value target for drug discovery to treat such pathologies. Using a FRET-based high-throughput screening assay that we previously reported, we identified small-molecule compounds that modulate the skeletal muscle channel isoform (RyR1) interaction with calmodulin and FK506 binding protein 12.6. Two such compounds, chloroxine and myricetin, increase FRET and inhibit [3H]ryanodine binding to RyR1 at nanomolar Ca2+. Both compounds also decrease RyR1 Ca2+ leak in human skinned skeletal muscle fibers. Furthermore, we identified compound concentrations that reduced leak by &gt; 50% but only slightly affected Ca2+ release in excitation-contraction coupling, which is essential for normal muscle contraction. This report demonstrates a pipeline that effectively filters small-molecule RyR1 modulators towards clinical relevance

The importance of history, language, change and challenge: What Vygotsky can teach sports coaches

Aims In recent years, recognition of the pedagogical nature of coaching has gained increasing traction. However, within this line of inquiry, only limited attention has been given to the work of Lev Vygotsky. The aim of this article is to construct a more comprehensive case about how Vygotsky’s principal ideas can aid our understanding of both the act and process of sports coaching. Methods The method involves constructing a case from Vygotsky’s original work, and how it has been interpreted by others, related to the applicability of using some of his concepts to further our understanding of sports coaching practice. The case presented represents an interpretive and considered approach to the question and task at hand. Discussion The discussion is centred on the utility of Vygotsky’s theorising to sports coaching practice. In particular his advocacy of (1) the cultural-historical perspective; (2) the claim of language as the greatest mediator in learning; (3) how perezhivane contributes to such knowledge generation; (4) the zone of proximal development and the role of the ‘more capable other’ within it; and (5) the dialectical approach, focussing on the dynamic relationship between everyday and scientific concepts, are given primacy . Conclusion Finally, a reflective conclusion summarises the main points made and suggests possible future courses of action

Minimising costs of environmental service provision: water-yield, salt-load and biodiversity targets with new tree planting in Simmons Creek Catchment, NSW, a dryland farming/grazing area.

Although dryland farming and grazing have been practiced for over 130 years in the 17,000 ha Simmons Creek catchment without surface salinity problems, the area has been identified as a significant source of salt seepage to Billabong Creek in the NSW Murray catchment. Groundwater movement and salinity levels are spatially heterogenous at Simmons Creek. Groundwater of the upper catchment is relatively fresh and seemingly unconnected with the highly saline groundwater of the lower catchment. However, fresh surface water does flow from the upper to the lower catchment. This spatial diversity provokes the question of where high-water-use forest habitats might be placed to achieve different combinations of environmental services (greater water yield, lower stream salinity and greater biodiversity) at least cost. Agro-forestry and or carbon sequestration benefits are not considered here. This paper presents methods and preliminary calculations of land use changes for least-cost delivery of these environmental service targets.Optimisation, opportunity costs, forest-habitat, environmental services, Environmental Economics and Policy,

Reprint of “The Single-Case Reporting Guideline In BEhavioural interventions (SCRIBE) 2016: explanation and elaboration”

There is substantial evidence that research studies reported in the scientific literature do not provide adequate information so that readers know exactly what was done and what was found. This problem has been addressed by the development of reporting guidelines which tell authors what should be reported and how it should be described. Many reporting guidelines are now available for different types of research designs. There is no such guideline for one type of research design commonly used in the behavioral sciences, the single-case experimental design (SCED). The present study addressed this gap. This report describes the Single-Case Reporting guideline In BEhavioural interventions (SCRIBE) 2016, which is a set of 26 items that authors need to address when writing about SCED research for publication in a scientific journal. Each item is described, a rationale for its inclusion is provided, and examples of adequate reporting taken from the literature are quoted. It is recommended that the SCRIBE 2016 is used by authors preparing manuscripts describing SCED research for publication, as well as journal reviewers and editors who are evaluating such manuscripts.Published versio

Telomere dynamics and homeostasis in a transmissible cancer

Devil Facial Tumour Disease (DFTD) is a unique clonal cancer that threatens the world\u27s largest carnivorous marsupial, the Tasmanian devil (Sarcophilus harrisii) with extinction. This transmissible cancer is passed between individual devils by cell implantation during social interactions. The tumour arose in a Schwann cell of a single devil over 15 years ago and since then has expanded clonally, without showing signs of replicative senescence; in stark contrast to a somatic cell that displays a finite capacity for replication, known as the &ldquo;Hayflick limit&rdquo;