Living Standards in Black and White: Evidence from the Heights of Ohio Prison Inmates, 1829 – 1913

The use of height data to measure living standards is now a well-established method in the economic history literature. Moreover, a number of core findings in this literature are widely agreed upon. There are still some populations, places, and times, however, for which anthropometric evidence remains thin. One example is African-Americans in the Northern US in the 1800s. Here, we use new data from the state prison in Ohio to track heights of black and white men from 1829 to 1913. We corroborate the well-known mid-century height decline among white men in Ohio, found by Steckel and Haurin (1994) using National Guard data. We find that black men in Ohio were shorter than white men, throughout the century and controlling for a number of characteristics. We also find a pattern of height decline in mid-century similar to that found for white men.

A Nested Logit Model of Recreational Fishing Demand in Alaska

Travel cost analysis, bioeconomic modeling, Public Economics, Research Methods/ Statistical Methods, Q26, Q22, C35,

Introgressive Hybridization and the Evolution of Lake-Adapted Catostomid Fishes.

Hybridization has been identified as a significant factor in the evolution of plants as groups of interbreeding species retain their phenotypic integrity despite gene exchange among forms. Recent studies have identified similar interactions in animals; however, the role of hybridization in the evolution of animals has been contested. Here we examine patterns of gene flow among four species of catostomid fishes from the Klamath and Rogue rivers using molecular and morphological traits. Catostomus rimiculus from the Rogue and Klamath basins represent a monophyletic group for nuclear and morphological traits; however, the Klamath form shares mtDNA lineages with other Klamath Basin species (C. snyderi, Chasmistes brevirostris, Deltistes luxatus). Within other Klamath Basin taxa, D. luxatus was largely fixed for alternate nuclear alleles relative to C. rimiculus, while Ch. brevirostris and C. snyderi exhibited a mixture of these alleles. Deltistes luxatus was the only Klamath Basin species that exhibited consistent covariation of nuclear and mitochondrial traits and was the primary source of mismatched mtDNA in Ch. brevirostris and C. snyderi, suggesting asymmetrical introgression into the latter species. In Upper Klamath Lake, D. luxatus spawning was more likely to overlap spatially and temporally with C. snyderi and Ch. brevirostris than either of those two with each other. The latter two species could not be distinguished with any molecular markers but were morphologically diagnosable in Upper Klamath Lake, where they were largely spatially and temporally segregated during spawning. We examine parallel evolution and syngameon hypotheses and conclude that observed patterns are most easily explained by introgressive hybridization among Klamath Basin catostomids

Living standards in black and white: evidence from the heights of Ohio prison inmates, 1829 - 1913

The use of height data to measure living standards is now a well-established method in the economic history literature. Moreover, a number of core findings in this literature are widely agreed upon. There are still some populations, places, and times, however, for which anthropometric evidence remains thin. One example is African-Americans in the Northern US in the 1800s. Here, we use new data from the state prison in Ohio to track heights of black and white men from 1829 to 1913. We corroborate the well-known mid-century height decline among white men in Ohio, found by Steckel and Haurin (1994) using National Guard data. We find that black men in Ohio were shorter than white men, throughout the century and controlling for a number of characteristics. We also find a pattern of height decline in midcentury similar to that found for white men

White-nose Syndrome at Mammoth Cave National Park: Actions Before and After Its Detection

Since it was identified in the United States in 2006, white-nose syndrome (WNS) in bats has become an important issue in the management of caves and bats at Mammoth Cave National Park (MACA). The threat of its arrival has led to more intense monitoring of bat populations, increased studies, and interventions with both the visiting public and researchers. The timeline of MACA’s WNS response is shown in Table 1

Attitude-referenced radiometer study. Volume 2 - Precision radiometric system

Attitude reference radiometer study for earth orbiting spacecraf

Detection of Sharp Symmetric Features in the Circumbinary Disk Around AK Sco

The Search for Planets Orbiting Two Stars (SPOTS) survey aims to study the formation and distribution of planets in binary systems by detecting and characterizing circumbinary planets and their formation environments through direct imaging. With the SPHERE Extreme Adaptive Optics instrument, a good contrast can be achieved even at small (<300 mas) separations from bright stars, which enables studies of planets and disks in a separation range that was previously inaccessible. Here, we report the discovery of resolved scattered light emission from the circumbinary disk around the well-studied young double star AK Sco, at projected separations in the ~13--40 AU range. The sharp morphology of the imaged feature is surprising, given the smooth appearance of the disk in its spectral energy distribution. We show that the observed morphology can be represented either as a highly eccentric ring around AK Sco, or as two separate spiral arms in the disk, wound in opposite directions. The relative merits of these interpretations are discussed, as well as whether these features may have been caused by one or several circumbinary planets interacting with the disk.Comment: 10 pages, 3 figures, accepted for publication in ApJ Letters. Minor (proof-level) corrections implemented in this versio

Inhibition of chemotherapy resistant breast cancer stem cells by a ROR1 specific antibody.

Breast cancers enduring treatment with chemotherapy may be enriched for cancer stem cells or tumor-initiating cells, which have an enhanced capacity for self-renewal, tumor initiation, and/or metastasis. Breast cancer cells that express the type I tyrosine kinaselike orphan receptor ROR1 also may have such features. Here we find that the expression of ROR1 increased in breast cancer cells following treatment with chemotherapy, which also enhanced expression of genes induced by the activation of Rho-GTPases, Hippo-YAP/TAZ, or B lymphoma Mo-MLV insertion region 1 homolog (BMI1). Expression of ROR1 also enhanced the capacity of breast cancer cells to invade Matrigel, form spheroids, engraft in Rag2-/-[Formula: see text] mice, or survive treatment with paclitaxel. Treatment of mice bearing breast cancer patient-derived xenografts (PDXs) with the humanized anti-ROR1 monoclonal antibody cirmtuzumab repressed expression of genes associated with breast cancer stemness, reduced activation of Rho-GTPases, Hippo-YAP/TAZ, or BMI1, and impaired the capacity of breast cancer PDXs to metastasize or reengraft Rag2-/-[Formula: see text] mice. Finally, treatment of PDX-bearing mice with cirmtuzumab and paclitaxel was more effective than treatment with either alone in eradicating breast cancer PDXs. These results indicate that targeting ROR1 may improve the response to chemotherapy of patients with breast cancer

Adynamia episodica hereditaria with myotonia: A non-inactivating sodium current and the effect of extracellular pH

To study the mechanism of periodic paralysis, we investigated the properties of intact muscle fibers biopsied from a patient who had adynamia episodica hereditaria with electromyographic signs of myotonia. When the potassium concentration in the extracellular medium, [K]e, was 3.5 mmol/l, force of contraction, membrane resting potential, and intracellular sodium activity were normal, but depolarizing voltage clamp steps revealed the existence of an abnormal inward current. This current was activated at membrane potentials less negative than -80 mV, reached a maximum within 50 msec, and was not inactivated with time. The inward current was completely and reversibly blocked by tetrodotoxin, which indicates that it was carried by sodium ions. In a solution containing 9 mmol/l potassium, normal muscle would depolarize to -63 mV and yet be capable of developing full tetanic force upon stimulation. The muscle from the patient depolarized to -57 mV and became inexcitable, i.e., it was paralyzed. A contracture did not develop. Lowering of the extracellular pH did not influence the resting potential, but it effectively antagonized or prevented the paralytic effect of high [K]e by changing the inactivation characteristics of the sodium channels. Hydrochlorothiazide, which had a therapeutic effect on the patient, did not prevent paralysis in vitro. An abnormal rise of the intracellular sodium activity was recorded when the extracellular potassium concentration was raised to 10 mmol/l