Effects of a group-mediated cognitive behavioral lifestyle intervention on select social cognitive outcomes in prostate cancer patients undergoing androgen deprivation therapy

Objective. To compare the effects of a group-mediated cognitive behavioral (GMCB) exercise and dietary (EX+D) intervention with those of standard-of-care (SC) treatment on select social cognitive outcomes in prostate cancer (PCa) patients undergoing androgen deprivation therapy (ADT). Methods. In the single-blind, 2-arm, randomized controlled Individualized Diet and Exercise Adherence–Pilot (IDEA-P) trial, 32 PCa patients (mean age = 66.2 years; SD = 7.8) undergoing ADT were randomly assigned to a 12-week EX+D intervention (n = 16) or SC treatment (n = 16). The exercise component of the personalized EX+D intervention integrated a combination of supervised resistance and aerobic exercise performed twice per week. The dietary component involved counseling and education to modify dietary intake and composition. Blinded assessments of social cognitive outcomes were obtained at baseline and 2-month and 3-month follow-up. Results. Intent-to-treat analysis of covariance demonstrated that the EX+D intervention resulted in significantly greater improvements in scheduling (P \u3c .05), coping (P \u3c .01), and exercise self-efficacy (P \u3c .05), and satisfaction with function (P \u3c .01) at 3 months relative to SC. Results of partial correlation analysis also demonstrated that select social cognitive outcomes were significantly correlated with primary trial outcomes of mobility performance and exercise participation (P \u3c .05) at 3-month follow-up. Conclusions: The GMCB lifestyle intervention yielded more favorable improvements in relevant social cognitive outcomes relative to SC among PCa patients undergoing ADT. Additionally, more favorable social cognitive outcomes were associated with superior mobility performance and exercise participation following the independent maintenance phase of the EX+D intervention

Proteomic profiling identifies specific histone species associated with leukemic and cancer cells

BACKGROUND: Chromatin is an extraordinarily complex structure. Much of this complexity results from the presence of numerous histone post-translational modifications and histone variants. Alterations in the patterns of histone post-translational modifications are emerging as a feature of many types of cancer and have been shown to have prognostic value. RESULTS: We have applied a liquid chromatography/mass spectrometry-based approach to comprehensively characterize the histone proteome in primary samples from chronic lymphocytic leukemia (CLL) patients, as well as bladder and breast cancer cell culture models. When compared to non-malignant CD19+ B cells from healthy donors, the CLL histone proteome showed a distinct signature of differentially expressed species, spanning all the histones studied and including both post-translationally modified species and unmodified, non-allelic replication-dependent histone isoforms. However, the large changes in histone H3 and H4 that are characteristic of many cancer types were not observed. One of species of H2A (mass = 14,063 Da) was the most strongly associated with time to treatment in CLL patients. CLL patient samples also demonstrated histone profiles that were distinct from those of the bladder and breast cancer cells. CONCLUSIONS: Signatures of histone profiles are complex and can distinguish between healthy individuals and CLL patients and may provide prognostic markers. In addition, histone profiles may define tissue specific malignancies. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12014-015-9095-4) contains supplementary material, which is available to authorized users

Vorträge zum 4. Darmstädter Geotechnik-Kolloquium am 13. März 1997

Mit dem Mitteilungsheft Nr. 37 publizieren das Institut und die Versuchsanstalt für Geotechnik der Technischen Hochschule Darmstadt die Beiträge zum 4. Darmstädter Geo- technik-Kolloquium mit den folgenden Themenschwerpunkten: - Internationale Projekte/Projekterfahrungen - Möglichkeiten und Grenzen der Kombinierten Pfahl-Plattengründung (KPP) - Rechtsfragen in der Geotechni

A Chaperone Trap Contributes to the Onset of Cystic Fibrosis

Protein folding is the primary role of proteostasis network (PN) where chaperone interactions with client proteins determine the success or failure of the folding reaction in the cell. We now address how the Phe508 deletion in the NBD1 domain of the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) protein responsible for cystic fibrosis (CF) impacts the binding of CFTR with cellular chaperones. We applied single ion reaction monitoring mass spectrometry (SRM-MS) to quantitatively characterize the stoichiometry of the heat shock proteins (Hsps) in CFTR folding intermediates in vivo and mapped the sites of interaction of the NBD1 domain of CFTR with Hsp90 in vitro. Unlike folding of WT-CFTR, we now demonstrate the presence of ΔF508-CFTR in a stalled folding intermediate in stoichiometric association with the core Hsps 40, 70 and 90, referred to as a ‘chaperone trap’. Culturing cells at 30 C resulted in correction of ΔF508-CFTR trafficking and function, restoring the sub-stoichiometric association of core Hsps observed for WT-CFTR. These results support the interpretation that ΔF508-CFTR is restricted to a chaperone-bound folding intermediate, a state that may contribute to its loss of trafficking and increased targeting for degradation. We propose that stalled folding intermediates could define a critical proteostasis pathway branch-point(s) responsible for the loss of function in misfolding diseases as observed in CF

Validierung des Modells von Lardy, Finkelstein, Yang und Khuong-Huu zur Berechnung eines eintägigen Credit-Value-at-Risk über Aktienäquivalenzpositionen

Während es im Aktienbereich verschiedene standardisierte Verfahren zur Risikomessung gibt, können diese nicht ohne weiteres zur Messung von spezifischen Zinsrisiken verwendet werden. Gründe hierfür sind folgende: Der Kreditmarkt ist ein relativ illiquider Markt. Historische Zeitreihen der Credit Spreads sind häufig lückenhaft bzw. zu kurz, um notwendige Parameter wie Volatilitäten und Korrelationen der Spreads schätzen zu können. Zudem weisen die empirischen Verteilungen der Spread-Renditen schwerere Tails auf als die Normalverteilung. Das Finkelstein-Modell nutzt die Verbindung/Korrelation zwischen Kredit- und Aktien-markt. In dieser Arbeit wurde die Möglichkeit untersucht, Spread-Risiken mittels Aktien zu hedgen und die Value-at-Risk-Schätzungen für die Aktienpositionen durchzuführen. Mit einem solchen Verfahren würde man das Problem des illiquiden Kreditmarktes umgehen. Zudem ist die Umsetzung eines solchen Modells in der Praxis deutlich einfacher als die Umsetzung eines komplexen Credit Spread basierten Modells, da ein VaR-Kalkulator für das Aktienrisiko zur Berechnung des Credit-Value-at-Risk eingesetzt werden kann

Folge 5: Anne Dippel über das „Leben in Metaphern“ und kulturanthropologische Überlegungen zum Verhältnis von KI und conditio humana im digitalen Zeitalter

Die Kulturwissenschaftlerin Anne Dippel (Jena) spricht über das CERN, KI, Cyborgs und wie das alles mit dem Mensch-Sein zusammenhängt. Im Gespräch mit Thomas Thiemeyer und Helen Ahner berichtet sie von ihrer Feldforschung im CERN und entfaltet kulturwissenschaftliche Lesarten technisierter Weltdeutungen

Folge 4: Julia Fleischhack über digitale Anthropologie

ulia Fleischhack (Göttingen) erklärt, warum das Forschen und Ethnografieren in digital(isiert)en Feldern ein Umdenken erfordert und welche Möglichkeiten sowie Herausforderungen das bedeutet

Folge 3: Maximilian Jablonowski über das Anthropozän, Narrativität und Ethik

Maximilian Jablonowski (Zürich) erzählt von Drohnen und Viren, davon, wie sie mit Menschen zusammenleben und erklärt, was das alles mit Technikforschung zu tun hat