Extending the limits of globule detection -- ISOPHOT Serendipity Survey Observations of interstellar clouds

A faint $I_{\rm 170}=4$ MJysr$^{-1}$ bipolar globule was discovered with the ISOPHOT 170 $\mu$m Serendipity Survey (ISOSS). ISOSS J 20246+6541 is a cold ($T_{\rm d}\approx 14.5$ K) FIR source without an IRAS pointsource counterpart. In the Digitized Sky Survey B band it is seen as a 3\arcmin size bipolar nebulosity with an average excess surface brightness of $\approx 26$ mag/$\square$\arcsec . The CO column density distribution determined by multi-isotopic, multi-level CO measurements with the IRAM-30m telescope agrees well with the optical appearance. An average hydrogen column density of $\approx 10^{21}$cm$^{-2}$ was derived from both the FIR and CO data. Using a kinematic distance estimate of 400 pc the NLTE modelling of the CO, HCO$^+$, and CS measurements gives a peak density of $\approx 10^4$cm$^{-3}$. The multiwavelength data characterise ISOSS 20246+6541 as a representative of a class of globules which has not been discovered so far due to their small angular size and low 100$\mu$m brightness. A significant overabundance of $^{13}$CO is found $X(^{13}CO) \ge 150\times X(C^{18}O)$. This is likely due to isotope selective chemical processes.Comment: 5 pages, 3 figure

Elective Open Suprarenal Aneurysm Repair in England from 2000 to 2010 an Observational Study of Hospital Episode Statistics

Background: Open surgery is widely used as a benchmark for the results of fenestrated endovascular repair of complex abdominal aortic aneurysms (AAA). However, the existing evidence stems from single-centre experiences, and may not be reproducible in wider practice. National outcomes provide valuable information regarding the safety of suprarenal aneurysm repair. Methods: Demographic and clinical data were extracted from English Hospital Episodes Statistics for patients undergoing elective suprarenal aneurysm repair from 1 April 2000 to 31 March 2010. Thirty-day mortality and five-year survival were analysed by logistic regression and Cox proportional hazards modeling. Results: 793 patients underwent surgery with 14% overall 30-day mortality, which did not improve over the study period. Independent predictors of 30-day mortality included age, renal disease and previous myocardial infarction. 5-year survival was independently reduced by age, renal disease, liver disease, chronic pulmonary disease, and known metastatic solid tumour. There was significant regional variation in both 30-day mortality and 5-year survival after risk-adjustment. Regional differences in outcome were eliminated in a sensitivity analysis for perioperative outcome, conducted by restricting analysis to survivors of the first 30 days after surgery. Conclusions: Elective suprarenal aneurysm repair was associated with considerable mortality and significant regional variation across England. These data provide a benchmark to assess the efficacy of complex endovascular repair of supra-renal aneurysms, though cautious interpretation is required due to the lack of information regarding aneurysm morphology. More detailed study is required, ideally through the mandatory submission of data to a national registry of suprarenal aneurysm repair

The first CCD photometric study of the open cluster NGC 2126

We present the first CCD photometric observations of the northern open cluster NGC 2126. Data were taken on eight nights in February and December 2002 with a total time span of ~57 hours. Almost 1000 individual V-band frames were examined to find short-period variable stars. We discovered six new variable stars, of which one is a promising candidate for an eclipsing binary with a pulsating component. Two stars were classified as delta Scuti stars and one as Algol-type eclipsing binary. Two stars are slow variables with ambiguous classification. From absolute VRI photometry we have estimated the main characteristics of the cluster: m-M=11.0+/-0.5, E(V-I)=0.4+/-0.1, E(V-R)=0.08+/-0.06 (E(B-V)=0.2+/-0.15) and d=1.3+/-0.6 kpc. Cluster membership is suggested for three variable stars from their positions on the colour-magnitude diagram.Comment: 7 pages, 10 figures, accepted for publication in A&

A genome-wide association study to identify genetic markers associated with endometrial cancer grade

RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are

ASASSN-18di: discovery of a ΔV∼10ΔV \sim 10 flare on a mid-M dwarf

We report and characterize a white-light superflare on a previously undiscovered M dwarf detected by the ASAS-SN survey. Employing various color-magnitude and color-spectral type relationships, we estimate several stellar parameters, including the quiescent V-band magnitude, from which we derive a flare amplitude of $\Delta V \sim 10$. We determine an r-band absolute magnitude of $M_{r} = 11.4$, consistent with a mid-M dwarf, and an approximate distance to the source of $2.2$ kpc. Using classical-flare models, we infer a flare energy of $E_{V} \simeq (4.1\pm 2.2)\times 10^{36}$ ergs, making this one of the strongest flares documented on an M dwarf

Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway.

A promising new compound class for treating human malaria is the imidazolopiperazines (IZP) class. IZP compounds KAF156 (Ganaplacide) and GNF179 are effective against Plasmodium symptomatic asexual blood-stage infections, and are able to prevent transmission and block infection in animal models. But despite the identification of resistance mechanisms in P. falciparum, the mode of action of IZPs remains unknown. To investigate, we here combine in vitro evolution and genome analysis in Saccharomyces cerevisiae with molecular, metabolomic, and chemogenomic methods in P. falciparum. Our findings reveal that IZP-resistant S. cerevisiae clones carry mutations in genes involved in Endoplasmic Reticulum (ER)-based lipid homeostasis and autophagy. In Plasmodium, IZPs inhibit protein trafficking, block the establishment of new permeation pathways, and cause ER expansion. Our data highlight a mechanism for blocking parasite development that is distinct from those of standard compounds used to treat malaria, and demonstrate the potential of IZPs for studying ER-dependent protein processing

The Rise and Peak of the Luminous Type IIn SN 2017hcc/ATLAS17lsn from ASAS-SN and Swift UVOT Data

We present observations of the rise and peak of the Type IIn supernova SN 2017hcc/ATLAS17lsn obtained by the All-Sky Automated Survey for Supernovae (ASAS-SN) and Swift UVOT. The light curve of SN 2017hcc/ATLAS17lsn peaks at $V\simeq 13.7$ mag, which from the estimated redshift of the host galaxy ($z=0.0168$, $D\simeq 73$ Mpc) implies an absolute peak magnitude $M_{V,peak} \simeq -20.7$ mag. The near-UV to optical spectral energy distribution of SN 2017hcc/ATLAS17lsn from Swift UVOT is consistent with a hot, but cooling blackbody with $\rm T_{bb}\simeq 16500$ K on Oct. 28.4 and $\rm T_{bb} \simeq 11700$ K on Nov. 19.6. The estimated peak bolometric luminosity $L_{bol, peak}\simeq 1.3\times 10^{44}$ erg s$^{-1}$ makes SN2017hcc/ATLAS17lsn one of the most luminous Type IIn supernovae studied to date. From the bolometric light curve we constrain the risetime to be $\sim 27$ days and the total radiated energy of the event to date is $4\times 10^{50}$ erg

Results of the randomized phase IIB ADMIRE trial of FCR with or without mitoxantrone in previously untreated CLL

ADMIRE was a multi-center, randomized-controlled, open, phase IIB superiority trial in previously untreated Chronic Lymphocytic Leukemia (CLL). Conventional frontline therapy in fit patients is fludarabine, cyclophosphamide and rituximab (FCR). Initial evidence from non-randomized Phase II trials suggested that the addition of mitoxantrone to FCR (FCM-R) improved remission rates. 215 patients were recruited to assess the primary endpoint of complete remission (CR) rates according to IWCLL criteria. Secondary endpoints were progression-free survival (PFS), overall survival (OS), overall response rate, minimal residual disease (MRD) negativity and safety. At final analysis, CR rates were 69.8% FCR vs 69.3% FCM-R [adjusted odds ratio (OR): 0.97; 95%CI: (0.53-1.79), P=0.932]. MRD-negativity rates were 59.3% FCR vs 50.5% FCM-R [adjusted OR: 0.70; 95% CI: (0.39-1.26), P=0.231]. During treatment, 60.0% (n=129) of participants received G-CSF as secondary prophylaxis for neutropenia, a lower proportion on FCR compared with FCM-R (56.1 vs 63.9%). The toxicity of both regimens was acceptable. There are no significant differences between the treatment groups for PFS and OS. The trial demonstrated that the addition of mitoxantrone to FCR did not increase the depth of response. Oral FCR was well tolerated and resulted in impressive responses in terms of CR rates and MRD negativity compared to historical series with intravenous chemotherapy

Ocean impact on decadal Atlantic climate variability revealed by sea-level observations

Decadal variability is a notable feature of the Atlantic Ocean and the climate of the regions it influences. Prominently, this is manifested in the Atlantic Multidecadal Oscillation (AMO) in sea surface temperatures. Positive (negative) phases of the AMO coincide with warmer (colder) North Atlantic sea surface temperatures. The AMO is linked with decadal climate fluctuations, such as Indian and Sahel rainfall1, European summer precipitation2, Atlantic hurricanes3 and variations in global temperatures4. It is widely believed that ocean circulation drives the phase changes of the AMO by controlling ocean heat content5. However, there are no direct observations of ocean circulation of sufficient length to support this, leading to questions about whether the AMO is controlled from another source6. Here we provide observational evidence of the widely hypothesized link between ocean circulation and the AMO. We take a new approach, using sea level along the east coast of the United States to estimate ocean circulation on decadal timescales. We show that ocean circulation responds to the first mode of Atlantic atmospheric forcing, the North Atlantic Oscillation, through circulation changes between the subtropical and subpolar gyres—the intergyre region7. These circulation changes affect the decadal evolution of North Atlantic heat content and, consequently, the phases of the AMO. The Atlantic overturning circulation is declining8 and the AMO is moving to a negative phase. This may offer a brief respite from the persistent rise of global temperatures4, but in the coupled system we describe, there are compensating effects. In this case, the negative AMO is associated with a continued acceleration of sea-level rise along the northeast coast of the United States9, 10