Treatment of Primary Pulmonary Aspergillosis: An Assessment of the Evidence.

Aspergillus spp. are a group of filamentous molds that were first described due to a perceived similarity to an aspergillum, or liturgical device used to sprinkle holy water, when viewed under a microscope. Although commonly inhaled due to their ubiquitous nature within the environment, an invasive fungal infection (IFI) is a rare outcome that is often reserved for those patients who are immunocompromised. Given the potential for significant morbidity and mortality within this patient population from IFI due to Aspergillus spp., along with the rise in the use of therapies that confer immunosuppression, there is an increasing need for appropriate initial clinical suspicion leading to accurate diagnosis and effective treatment. Voriconazole remains the first line agent for therapy; however, the use of polyenes, novel triazole agents, or voriconazole in combination with an echinocandin may also be utilized. Consideration as to which particular agent and for what duration should be made in the individual context for each patient based upon underlying immunosuppression, comorbidities, and overall tolerance of therapy

Securing the premises

How effective are different home security devices, on their own and in combination with others? Andromachi Tseloni and Rebecca Thompson analyse crime survey data in search of answers

A network-based view of regional growth

The need to better understand the mechanisms underlying regional growth patterns is widely recognised. This paper argues that regional growth is partly a function of the value created through inter-organisational flows of knowledge within and across regions. It is proposed that investment in calculative networks by organisations to access knowledge is a form of capital, termed network capital, which should be incorporated into regional growth models. The paper seeks to develop a framework to capture the value of network capital within these models based on the spatial configuration and the nature of the knowledge flowing through networks

In vivo measurement of mechanical impedance of bone

System of measurement provides indications of ulnar properties independent of characteristics of surrounding soft tissue and other bones. Mechanical modal approximated ulnar response so average bending rigidity could be determined to provide direct index of bone resistance to bending loading

Fighting covid-19 outbreaks in prisons

Improving prison health services is critical for fighting epidemics such as covid-19. Prisoners are at much higher risk of infectious diseases than communities outside. Eruption of covid-19 in prisons emphasises the need to improve prison healthcare. Health education for inmates and prison staff must be intensified, and better treatment and prevention measures require increased funding. More non-custodial sentences would decongest prisons, reducing the potential for the outbreaks. Links between prison and national health services should be strengthened

SNAP 8 refractory boiler development program - Mercury thermal shock testing of 2 1/2-inch-diameter bimetallic joints for SNAP 8 applications Topical report no. 4

Thermal shock testing of coextruded and brazed tubular joints of stainless steel and tantalum for SNAP-8 applicatio

Counterparty Risk in Insurance Contracts: Should the Insured Worry about the Insurer?

We analyze the effect of counterparty risk on insurance contracts using the case of credit risk transfer in banking. In addition to the familiar moral hazard problem caused by the insuree's ability to influence the probability of a claim, this paper uncovers a new moral hazard problem on the other side of the market. We show that the insurer's investment strategy may not be in the best interests of the insuree. The reason for this is that if the insurer believes it is unlikely that a claim will be made, it is advantageous for them to invest in assets which earn higher returns, but may not be readily available if needed. This paper models both of these moral hazard problems in a unified framework. We find that instability in the insurer can create an incentive for the insuree to reveal superior information about the risk of their "investment". In particular, a unique separating equilibrium may exist even in the absence of any signalling device. We extend the model and show that increasing the number of insurers with which the insuree contracts can exacerbate the moral hazard problem and may not decrease counterparty risk. Our research suggests that regulators should be wary of risk being offloaded to other, possibly unstable parties, especially in newer financial markets such as that of credit derivatives.Counterparty Risk, Moral Hazard, Insurance, Banking, Credit Derivatives

Results of Large Area Crop Inventory Experiment (LACIE) drought analysis (South Dakota drought 1976)

LACIE using techniques developed from the southern Great Plains drought analysis indicated the potential for drought damage in South Dakota. This potential was monitored and as it became apparent that a drought was developing, LACIE implemented some of the procedures used in the southern Great Plains drought. The technical approach used in South Dakota involved the normal use of LACIE sample segments (5 x 6 nm) every 18 days. Full frame color transparencies (100 x 100 nm) were used on 9 day intervals to identify the drought area and to track overtime. The green index number (GIN) developed using the Kauth transformation was computed for all South Dakota segments and selected North Dakota segments. A scheme for classifying segments as drought affected or not affected was devised and tested on all available 1976 South Dakota data. Yield model simulations were run for all CRD's Crop Reporting District) in South Dakota