Present and future pharmacotherapeutic agents in heart failure: an evolving paradigm

Many conditions culminate in heart failure (HF), a multi-organ systemic syndrome with an intrinsically poor prognosis. Pharmacotherapeutic agents that correct neurohormonal dysregulation and haemodynamic instability have occupied the forefront of developments within the treatment of HF in the past. Indeed, multiple trials aimed to validate these agents in the 1980s and early 1990s, resulting in a large and robust evidence-base supporting their use clinically. An established treatment paradigm now exists for the treatment of HF with reduced ejection fraction (HFrEF), but there have been very few notable developments in recent years. HF remains a significant health concern with an increasing incidence as the population ages. We may indeed be entering the surgical era for HF treatment, but these therapies remain expensive and inaccessible to many. Newer pharmacotherapeutic agents are slowly emerging, many targeting alternative therapeutic pathways, but with mixed results. Metabolic modulation and manipulation of the nitrate/nitrite/nitric oxide pathway have shown promise and could provide the answers to fill the therapeutic gap between medical interventions and surgery, but further definitive trials are warranted. We review the significant evidence base behind the current medical treatments for HFrEF, the physiology of metabolic impairment in HF, and discuss two promising novel agents, perhexiline and nitrite

Sterile Abscess in the Myocardium after Direct Intramyocardial Injection Related to Gene Therapy in a Swine Model

Cardiac gene therapy is one of the most promising approaches to cure patients with cardiac dysfunctions. Many ways of efficient gene transfer using viral vectors are tested, and some of them are already used in clinical settings. However, it is always important to be keenly alert to the possible complications when a new therapy is introduced. We present a case of myocardial sterile abscess in a swine model associated with a direct myocardial injection

Geheimnisse sind erlaubt: Ein Lehrmittel zum Thema Datenschutz für den Zyklus 1

In Zusammenarbeit mit dem Datenschutzbeauftragten des Kantons Zürich entwickelte das Digital Learning mit Fachautorinnen der PH Zürich das Lehrmittel «Geheimnisse sind erlaubt», mit dem Lehrpersonen des Zyklus 1 das Thema Datenschutz in ihrem Unterricht vermitteln können. Wer sich selbstbestimmt, kritisch und verantwortungsvoll in der (digitalen) Lebenswelt bewegen möchte, braucht im Umgang mit der Privatsphäre und persönlichen Daten bestimmte Fähigkeiten und Fertigkeiten. Mit den altersgemässen Unterrichtsmaterialien erarbeiten die Schülerinnen und Schüler die nötigen Grundlagen für den Aufbau dieser Kompetenzen.+repphzhbib2019

Frankfurt-Dreieck zur Bildung in der digital vernetzten Welt. Ein interdisziplinäres Modell

Contemporary communication and social interaction are being increasingly influenced by media and technology, systems, and platforms that are based on digital principles and artificial intelligence. To date, there has been no clear set of interdisciplinary theories or models that go beyond the academic discourses within the individual disciplines. There has therefore been no clear framework within which to classify the current opportunities, challenges and responsibilities facing a digital society and how to approach education from a theoretical and conceptual perspective. In 2019, in recognition of the fact that digitalization and AI cannot be viewed from a single disciplinary perspective, a group of authors – consisting of scholars from computer science, media education and media studies – developed the Frankfurt Triangle (Brinda et al. 2020). The Frankfurt Triangle is the result of intensive interdisciplinary discussion. Its goal is to develop a collaborative theoretical and conceptual model on which to base the perspectives and dimensions of education in a digital world. The initial impetus for this augmentation of the Dagstuhl Declaration from 2016 came from two workshops took place in Frankfurt am Main, Germany. Incorporating a threefold perspective on a) structures and functions of technology and media, b) interrelations with culture and society, and c) interaction in terms auf use, agency and subjectification, the model provides an orientational framework for the analysis, reflection and active creation of artifacts and phenomena in a world shaped by digital media, technology, systems, and platforms. The model was originally developed in German and has not yet been translated into other languages. Furthermore, scientists have repeatedly pointed out at international conferences and in academic exchanges that no attempts have yet been made in other language areas to develop a comparable interdisciplinary model. Hence, in order to make the approach accessible to international scholars, the model and accompanying text have been translated into English. This paper describes the model, its function and usage, and outlines possible additional developments and future connections. The introductory text also briefly describes the context in which the model was developed, and its development since its inception. (DIPF/Orig.)Kommunikation und soziale Interaktion werden zunehmend von Medien und Technik, von Systemen und Plattformen beeinflusst, die auf digitalen Prinzipien und KI beruhen. Bislang gab es keine interdisziplinären Theorien oder konzeptionelle Modelle, die über die akademischen Diskurse einzelner Disziplinen hinausgehen. Es gab daher bisher keinen überfachlichen Orientierungsrahmen, in dem die aktuellen Chancen, Herausforderungen und Verantwortlichkeiten einer digitalen Gesellschaft eingeordnet werden können und entsprechend auch kein theoriebasiertes interdisziplinäres Modell zur «digitalen Bildung». Da Digitalisierung nicht aus der Perspektive von Einzeldisziplinen betrachtet werden sollte, hat eine Gruppe von Autor:innen aus Deutschland, Österreich und der Schweiz – bestehend aus Wissenschaftler:innen aus der Informatik, der Medienwissenschaft und der erziehungswissenschaftlichen Medienpädagogik – das Frankfurter Dreieck entwickelt (Brinda et al. 2020). Das Modell ist Ergebnis einer intensiven interdisziplinären Diskussion. Ziel des Modells ist es, einen gemeinsamen theoretischen und konzeptionellen Orientierungsrahmen zu entwickeln, der die unterschiedlichen Perspektiven und Dimensionen von Bildung in einer digitalen Welt beschreibt und begründet. Die Initialzündung für diese Erweiterung der Dagstuhl-Erklärung aus dem Jahr 2016 entstand in zwei Workshops in Frankfurt am Main. In der dreifachen Perspektive auf a) Strukturen und Funktionen von Technik und Medien, b) Wechselbeziehungen mit Kultur und Gesellschaft und c) sozialer Interaktion bietet das theoretische Modell einen Orientierungsrahmen für die Analyse, Reflexion und Gestaltung von Artefakten und Phänomenen in einer von digitalen Medien, Technik, Systemen und Plattformen geprägten Welt. Das theoretisch-konzeptionelle Modell wurde ursprünglich in deutscher Sprache verfasst und wurde bisher nicht in andere Sprachen übersetzt. Die Autor:innen wurden auf internationalen Konferenzen und im akademischen Austausch immer wieder darauf hingewiesen, dass in anderen Sprachräumen bisher noch keine vergleichbaren interdisziplinären Modelle entwickelt wurden. Um das Frankfurt Dreieck internationalen Wissenschaftlern zugänglich zu machen, wurde das theoretisch-konzeptionelle Modell sowie dessen Begleittexte ins Englische übersetzt. Das vorliegende Papier beschreibt das Modell, deren Funktion und Anwendung und skizziert abschliessend mögliche Weiterentwicklungen und zukünftige Verbindungen. Der einleitende Text beschreibt auch kurz den Kontext, in dem das Modell entstanden ist sowie seine Genese seit seiner Erstveröffentlichung in deutscher Sprache. (DIPF/Orig.

OBSERVATÓRIO DE NEGÓCIOS E INOVAÇÃO (ONI): UM PROJETO DE EXTENSÃO TECNOLÓGICA DA UNIVERSIDADE FEDERAL DA GRANDE DOURADOS

Este artigo teve como objetivo descrever as ações do projeto de extensão “Observatório de Negócios e Inovação” (ONi), bem como apresentar as percepções dos alunos integrantes. O projeto de extensão ONi tem como objetivo principal identificar e solucionar as principais dificuldades enfrentadas pela gestão de negócios e inovação em Microempresas (ME), Empresas de Pequeno Porte (EPP), Microempreendedor Individual (MEI) e Pequenos Produtores na região de Dourados e sua grande área circundante, por meio da oferta de assessoria e consultoria gratuita. O projeto é fundamentado na metodologia do PDCA (Planejar, Executar, Verificar e Agir), que visa aprimorar os processos e impulsionar o desenvolvimento desses empreendimentos. Os participantes têm a oportunidade de se envolver diretamente no crescimento de negócios locais, promovendo o empreendedorismo e a inovação na região. Por meio dos resultados, observou-se que os extensionistas participantes têm compreendido a necessidade de desenvolver seus conhecimentos e habilidades neste campo

Fatores que influenciam o desenvolvimento de empresas incubadas: uma pesquisa de perspectiva / Factors that influence the development of incubated enterprises: a perspective research

RESUMOOs empreendedores que criam negócios sob a forma de micro e pequenas empresas têm se instalado em incubadoras a fim de reduzir as instabilidades inerentes a um mercado repleto de incertezas e permeado por fortes barreiras para novos entrantes. Atrelado a essa realidade, o objetivo desta pesquisa é identificar os fatores que influenciam o processo de desenvolvimento de negócios através das perspectivas de incubadoras e de empresas incubadas. Selecionou-se três incubadoras e três empresas incubadas para participarem de entrevistas individuais semiestruturadas. A coleta dos dados se deu por meio de gravação. Os fatores resultantes das entrevistas foram agrupados em macro fatores, indicando que os fatores de sucesso ou fracasso percebidos pelos respondentes são o Perfil do Empreendedor, a Incubadora, os Recursos Financeiros e o Mercado. É possível concluir que o perfil do empreendedor é o fator mais forte, sob a perspectiva das incubadoras, uma vez que foi citado por todas as respondentes. Em contrapartida, a incubadora, e como esta desempenha suas funções, foi citada por todas as empresas incubadas, indicando, assim, sob a perspectiva dos empreendedores, ser o fator mais forte.

Factors that influence the development of incubated enterprises : a perspective research

Os empreendedores que criam negócios sob a forma de micro e pequenas empresas têm se instalado em incubadoras a fim de reduzir as instabilidades inerentes a um mercado repleto de incertezas e permeado por fortes barreiras para novos entrantes. Atrelado a essa realidade, o objetivo desta pesquisa é identificar os fatores que influenciam o processo de desenvolvimento de negócios através das perspectivas de incubadoras e de empresas incubadas. Selecionou-se três incubadoras e três empresas incubadas para participarem de entrevistas individuais semiestruturadas. A coleta dos dados se deu por meio de gravação. Os fatores resultantes das entrevistas foram agrupados em macro fatores, indicando que os fatores de sucesso ou fracasso percebidos pelos respondentes são o Perfil do Empreendedor, a Incubadora, os Recursos Financeiros e o Mercado. É possível concluir que o perfil do empreendedor é o fator mais forte, sob a perspectiva das incubadoras, uma vez que foi citado por todas as respondentes. Em contrapartida, a incubadora, e como esta desempenha suas funções, foi citada por todas as empresas incubadas, indicando, assim, sob a perspectiva dos empreendedores, ser o fator mais forte.Entrepreneurs who create businesses in the form of micro and small businesses have been installed in incubators in order to reduce the instabilities inherent in a market fraught with uncertainties and permeated by strong barriers for new entrants. Linked to this reality, the objective of this research is to identify the factors that influence the process of business development through the perspectives of incubators and incubated companies. Three incubators and three incubated companies were selected to participate in semi-structured individual interviews. Data was collected by means of recording. Factors resulting from the interviews were grouped into macro factors, indicating that the factors of success or failure perceived by the respondents are the Entrepreneur's Profile, Incubator, Financial Resources, and Market. It is possible to conclude that the entrepreneur's profile is the strongest factor, from the incubators' perspective, since it was mentioned by all the respondents. In contrast, the incubator, and how it performs its functions, was cited by all incubated companies, thus indicating, from the entrepreneurs' perspective, the strongest factor

AAV9.I-1c Delivered via Direct Coronary Infusion in a Porcine Model of Heart Failure Improves Contractility and Mitigates Adverse Remodeling

Heart failure is characterised by impaired function and disturbed Ca2+ homeostasis. Transgenic increases in inhibitor-1 activity have been shown to improve Ca2 cycling and preserve cardiac performance in the failing heart. The aim of this study is to evaluate the effect of activating the inhibitor (I-1c) of protein phosphatase 1 (I-1) through gene transfer on cardiac function in a porcine model of heart failure induced by myocardial infarction (MI)

Dispositivo simulador de braço para prática de procedimentos injetáveis

Universidade Federal do Rio Grande do SulEngenhariaEnfermagemMatemáticaDepositad