SSME structural dynamic model development

A mathematical model of the Space Shuttle Main Engine (SSME) as a complete assembly, with detailed emphasis on LOX and High Fuel Turbopumps is developed. The advantages of both complete engine dynamics, and high fidelity modeling are incorporated. Development of this model, some results, and projected applications are discussed

Tracking ocean wave spectrum from SAR images

An end to end algorithm for recovery of ocean wave spectral peaks from Synthetic Aperture Radar (SAR) images is described. Current approaches allow precisions of 1 percent in wave number, and 0.6 deg in direction

Gravitational waves in preheating

We study the evolution of gravitational waves through the preheating era that follows inflation. The oscillating inflaton drives parametric resonant growth of scalar field fluctuations, and although super-Hubble tensor modes are not strongly amplified, they do carry an imprint of preheating. This is clearly seen in the Weyl tensor, which provides a covariant description of gravitational waves.Comment: 8 pages, 8 figures, Revte

(Giant) Vortex - (anti) vortex interaction in bulk superconductors: The Ginzburg-Landau theory

The vortex-vortex interaction potential in bulk superconductors is calculated within the Ginzburg-Landau (GL) theory and is obtained from a numerical solution of a set of two coupled non-linear GL differential equations for the vector potential and the superconducting order parameter, where the merger of vortices into a giant vortex is allowed. Further, the interaction potentials between a vortex and a giant vortex and between a vortex and an antivortex are obtained for both type-I and type-II superconductors. Our numerical results agree asymptotically with the analytical expressions for large inter-vortex separations which are available in the literature. We propose new empirical expressions valid over the full interaction range, which are fitted to our numerical data for different values of the GL parameter

The tarantula toxin GxTx detains K+ channel gating charges in their resting conformation.

Allosteric ligands modulate protein activity by altering the energy landscape of conformational space in ligand-protein complexes. Here we investigate how ligand binding to a K+ channel's voltage sensor allosterically modulates opening of its K+-conductive pore. The tarantula venom peptide guangxitoxin-1E (GxTx) binds to the voltage sensors of the rat voltage-gated K+ (Kv) channel Kv2.1 and acts as a partial inverse agonist. When bound to GxTx, Kv2.1 activates more slowly, deactivates more rapidly, and requires more positive voltage to reach the same K+-conductance as the unbound channel. Further, activation kinetics are more sigmoidal, indicating that multiple conformational changes coupled to opening are modulated. Single-channel current amplitudes reveal that each channel opens to full conductance when GxTx is bound. Inhibition of Kv2.1 channels by GxTx results from decreased open probability due to increased occurrence of long-lived closed states; the time constant of the final pore opening step itself is not impacted by GxTx. When intracellular potential is less than 0 mV, GxTx traps the gating charges on Kv2.1's voltage sensors in their most intracellular position. Gating charges translocate at positive voltages, however, indicating that GxTx stabilizes the most intracellular conformation of the voltage sensors (their resting conformation). Kinetic modeling suggests a modulatory mechanism: GxTx reduces the probability of voltage sensors activating, giving the pore opening step less frequent opportunities to occur. This mechanism results in K+-conductance activation kinetics that are voltage-dependent, even if pore opening (the rate-limiting step) has no inherent voltage dependence. We conclude that GxTx stabilizes voltage sensors in a resting conformation, and inhibits K+ currents by limiting opportunities for the channel pore to open, but has little, if any, direct effect on the microscopic kinetics of pore opening. The impact of GxTx on channel gating suggests that Kv2.1's pore opening step does not involve movement of its voltage sensors

The ISIS synchrotron beam control and study programme

Progress on the beam control and study programme for the 800 MeV High Intensity Proton Synchrotron of the Spallation Neutron Source ISIS, is outlined. Recent hardware upgrades to diagnostics, instrumentation and computing have increased the amount, accuracy and availability of beam information. The measurement methods employed and their planned applications for beam control, optimisation and study are described. Work includes detailed study of longitudinal and transverse dynamics at high and low intensity. Results obtained so far and future plans are summarised. (6 refs)