The decline of son preference and rise of gender indifference in Taiwan since 1990

This study explores the change of married women’s sex preference for children in Taiwan since 1990, finding that there was a substantial decline of son preference and rise of “gender indifferenceâ€, defined as feeling indifferent about children’s sex (as opposed to desiring an equal number of boys and girls, in which the sex of children is still a primary consideration). Results show that at the individual level female education was the strongest predictor for the preference; education was negatively associated with son preference and positively with gender indifference. Cohort difference was noticeable as well. Younger cohorts were better educated than older ones hence they were more neutral about the sex and less adherent to the traditional male preference. In addition from 1992 to 2002 there was a universal intra cohort movement toward gender neutrality and away from son preference. When the younger cohorts gradually replaced the older ones as the main child bearers in Taiwanese society, at the aggregate level son preference declined and gender indifference rose.education, gender indifference, son preference, Taiwan

Son preference and children's housework: The case of India

Son preference in countries like India results in higher female infant mortality rates and differentially lower access to health care and education for girls than for boys. We use a nationally representative survey of Indian households (NFHS-3) to conduct the first study that analyzes whether son preference is associated with girls bearing a larger burden of housework than boys. Housework is a non-negligible part of child labor in which around 60% of children in our sample are engaged. The preference for male offspring is measured by a mother's ideal proportion of sons among her offspring. We show that when the ideal proportion increases from 0 to 1, the gap in the time spent on weekly housework for an average girl compared to that of boy increases by 2.5 hours. We conduct several robustness analyses. First, we estimate the main model separately by caste, religion and family size. Second, we use a two-stage model to look at participation into housework (as well as other types of work) in addition to hours. Third, we use mother's fertility intentions as an alternative measure of son preference. The analysis confirms that stated differences in male-preference translate in de facto differences in girl's treatment

Antioxidant Activities of the Methanol Extracts of Various Parts of Phalaenopsis Orchids with White, Yellow, and Purple Flowers

Phalaenopsis (Phal.) orchids including white, yellow, and purple flowers are some of the most important commercial orchids worldwide. These flowering plants can be considered to be promising sources of antioxidants since several medicinal orchids were shown to have potential antioxidant activities. The antioxidant activities and several secondary metabolite compounds of the methanolic extracts of four parts (the root, pedicel, leaf, and flower) of three hybrids of white (Phal. ‘City More’), yellow (Phal. ‘Sogo Meili’), and purple (Phal. ‘Queen Beer’) flowering orchids were investigated. Results showed that the highest levels of chlorophyll a and chlorophyll b were respectively obtained in leaf extracts of white and purple orchids, whereas carotenoid showed the highest content in the flower extract of the yellow orchid. Among all tested extracts, flavonoids and anthocyanin demonstrated the highest levels in the flower extract of the purple orchid, whereas the highest level of polyphenols was observed in the flower extract of the yellow orchid. The leaf extract of the white orchid was the most effective extract with a 50% inhibitory concentration in the DPPH-scavenging activity assay, while the highest ferrous iron-chelating effect was observed in flower extracts of the yellow orchid and purple orchid, and the pedicel extract of the purple orchid. In the reducing power assay, the flower extract of the white orchid showed the most potent extract, followed by the leaf extract of the yellow orchid and the flower extract of the purple orchid. Relationships between flower colors and antioxidant activities of these orchids showed them to be potential sources of antioxidants for both medicinal use and stress-tolerance in these orchids

Combining statistics from two national complex surveys to estimate injury rates per hour exposed and variance by activity in the USA

BACKGROUND: A common issue in descriptive injury epidemiology is that in order to calculate injury rates that account for the time spent in an activity, both injury cases and exposure time of specific activities need to be collected. In reality, few national surveys have this capacity. To address this issue, we combined statistics from two different national complex surveys as inputs for the numerator and denominator to estimate injury rate, accounting for the time spent in specific activities and included a procedure to estimate variance using the combined surveys. METHODS: The 2010 National Health Interview Survey (NHIS) was used to quantify injuries, and the 2010 American Time Use Survey (ATUS) was used to quantify time of exposure to specific activities. The injury rate was estimated by dividing the average number of injuries (from NHIS) by average exposure hours (from ATUS), both measured for specific activities. The variance was calculated using the \u27delta method\u27, a general method for variance estimation with complex surveys. RESULTS: Among the five types of injuries examined, \u27sport and exercise\u27 had the highest rate (12.64 injuries per 100 000 h), followed by \u27working around house/yard\u27 (6.14), driving/riding a motor vehicle (2.98), working (1.45) and sleeping/resting/eating/drinking (0.23). The results show a ranking of injury rate by activity quite different from estimates using population as the denominator. CONCLUSIONS: Our approach produces an estimate of injury risk which includes activity exposure time and may more reliably reflect the underlying injury risks, offering an alternative method for injury surveillance and research

Comparison of Antimicrobial Susceptibility Testing of Isolates from Blood Cultures by Direct Inoculation Method and PHOENIX

Background: Bloodstream infection (BSI) is an important cause of serious morbidity and mortality for hospitalized patients. Empirically Gram stain of bacteria gives the first clue for the etiology of infection and medical treatment. But the delayed treatment on 1 or 2 days after phenotypic identification and drug susceptibility testing may cause potential danger to patients. Rapid drug susceptibility testing can provide earlier information to guide treatment and in less time than bacterial culture and sensitivity testing, for antibiotics therapy. Methods: In this study, we excluded samples of polymicrobial bacteremia. We collected isolates from 815 infection episodes caused by Escherichia coli (57%), Klebsiella pneumoniae (20.16%), Enterobacter cloacae (6%), Ps.aeruginosa (9.1%), Stenotrophomonas maltophilia (3.1%), and Acinetobacter baumannii (3.1%) in a 10-month period. We identified those bacteria with direct susceptibility test with the use of Phoenix100 (BD) during a 10-month period. Results: The results of direct susceptibility were concordant (99%-100%) with those obtained from Phoenix100. Conclusion: These results have the potential to guide clinicians to initiate an early antimicrobial therapy in febrile patients with sepsis shock

The efficacy and safety of Yupingfeng Powder with variation in the treatment of allergic rhinitis: Study protocol for a randomized, double-blind, placebo-controlled trial

Background: Allergic rhinitis (AR) is an upper airways chronic inflammatory disease mediated by IgE, which affects 10%–20% of the population. The mainstay for allergic rhinitis nowadays include steroids and antihistamines, but their effects are less than ideal. Many patients therefore seek Chinese medicine for treatment and Yupingfeng Powder is one of the most common formulae prescribed. In this study, we aim to investigate the efficacy and safety of Yupingfeng Powder with variation for the treatment of allergic rhinitis.Study design: This is a double-blind, randomized, placebo-controlled trial. A 2-week screening period will be implemented, and then eligible subjects with allergic rhinitis will receive interventions of either “Yupingfeng Powder with variation” granules or placebo granules for 8 weeks, followed by post treatment visits at weeks 12 and 16. The change in the Total Nasal Symptom Score (TNSS) will be used as the primary outcome.Discussion: This trail will evaluate the efficacy and safety of Yupingfeng Powder in treating allergic rhinitis. The study may provide the solid evidence of Yupingfeng Powder with variation can produce better clinical efficacy than the placebo granules.Trial registration:ClinicalTrials.gov, identifier NCT04976023

5-Fluorouracil Induced Intestinal Mucositis via Nuclear Factor-κB Activation by Transcriptomic Analysis and In Vivo Bioluminescence Imaging

5-Fluorouracil (5-FU) is a commonly used drug for the treatment of malignant cancers. However, approximately 80% of patients undergoing 5-FU treatment suffer from gastrointestinal mucositis. The aim of this report was to identify the drug target for the 5-FU-induced intestinal mucositis. 5-FU-induced intestinal mucositis was established by intraperitoneally administering mice with 100 mg/kg 5-FU. Network analysis of gene expression profile and bioluminescent imaging were applied to identify the critical molecule associated with 5-FU-induced mucositis. Our data showed that 5-FU induced inflammation in the small intestine, characterized by the increased intestinal wall thickness and crypt length, the decreased villus height, and the increased myeloperoxidase activity in tissues and proinflammatory cytokine production in sera. Network analysis of 5-FU-affected genes by transcriptomic tool showed that the expression of genes was regulated by nuclear factor-κB (NF-κB), and NF-κB was the central molecule in the 5-FU-regulated biological network. NF-κB activity was activated by 5-FU in the intestine, which was judged by in vivo bioluminescence imaging and immunohistochemical staining. However, 5-aminosalicylic acid (5-ASA) inhibited 5-FU-induced NF-κB activation and proinflammatory cytokine production. Moreover, 5-FU-induced histological changes were improved by 5-ASA. In conclusion, our findings suggested that NF-κB was the critical molecule associated with the pathogenesis of 5-FU-induced mucositis, and inhibition of NF-κB activity ameliorated the mucosal damage caused by 5-FU

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead