The role of inhibitory G proteins and regulators of G protein signaling in the in vivo control of heart rate and predisposition to cardiac arrhythmias

Inhibitory heterotrimeric G proteins and the control of heart rate. The activation of cell signaling pathways involving inhibitory heterotrimeric G proteins acts to slow the heart rate via modulation of ion channels. A large number of Regulators of G protein signalings (RGSs) can act as GTPase accelerating proteins to inhibitory G proteins and thus it is important to understand the network of RGS\G-protein interaction. We will review our recent findings on in vivo heart rate control in mice with global genetic deletion of various inhibitory G protein alpha subunits. We will discuss potential central and peripheral contributions to the phenotype and the controversies in the literature

What Does Clustering Tell Us About the Buildup of the Red Sequence?

We analyze the clustering of red and blue galaxies from four samples spanning a redshift range of 0.4<z<2.0 to test the various scenarios by which galaxies evolve onto the red sequence. The data are taken from the UKIDSS Ultra Deep Survey, DEEP2, and COMBO-17. The use of clustering allows us to determine what fraction of the red sequence is made up of central galaxies and satellite galaxies. At all redshifts, including z=0, the data are consistent with ~60% of satellite galaxies being red or quenched, implying that ~1/3 of the red sequence is comprised of satellite galaxies. More than three-fourths of red satellite galaxies were moved to the red sequence after they were accreted onto a larger halo. The constant fraction of satellite galaxies that are red yields a quenching time for satellite galaxies that depends on redshift in the same way as halo dynamical times; t_Q ~ (1+z)^{-1.5}. In three of the four samples, the data favor a model in which red central galaxies are a random sample of all central galaxies; there is no preferred halo mass scale at which galaxies make the transition from star-forming to red and dead. The large errors on the fourth sample inhibit any conclusions. Theoretical models in which star formation is quenched above a critical halo mass are excluded by these data. A scenario in which mergers create red central galaxies imparts a weaker correlation between halo mass and central galaxy color, but even the merger scenario creates tension with red galaxy clustering at redshifts above 0.5. These results suggest that the mechanism by which central galaxies become red evolves from z=0.5 to z=0.Comment: 18 emulateapj pages, 13 figures. submitted to Ap

Where do "red and dead" early-type void galaxies come from?

Void regions of the Universe offer a special environment for studying cosmology and galaxy formation, which may expose weaknesses in our understanding of these phenomena. Although galaxies in voids are observed to be predominately gas rich, star forming and blue, a sub-population of bright red void galaxies can also be found, whose star formation was shut down long ago. Are the same processes that quench star formation in denser regions of the Universe also at work in voids? We compare the luminosity function of void galaxies in the 2dF Galaxy Redshift Survey, to those from a galaxy formation model built on the Millennium Simulation. We show that a global star formation suppression mechanism in the form of low luminosity "radio mode" AGN heating is sufficient to reproduce the observed population of void early-types. Radio mode heating is environment independent other than its dependence on dark matter halo mass, where, above a critical mass threshold of approximately M_vir~10^12.5 M_sun, gas cooling onto the galaxy is suppressed and star formation subsequently fades. In the Millennium Simulation, the void halo mass function is shifted with respect to denser environments, but still maintains a high mass tail above this critical threshold. In such void halos, radio mode heating remains efficient and red galaxies are found; collectively these galaxies match the observed space density without any modification to the model. Consequently, galaxies living in vastly different large-scale environments but hosted by halos of similar mass are predicted to have similar properties, consistent with observations.Comment: 6 pages, 3 figures, accepted MNRA

Star Formation Quenching Timescale of Central Galaxies in a Hierarchical Universe

Central galaxies make up the majority of the galaxy population, including the majority of the quiescent population at $\mathcal{M}_* > 10^{10}\mathrm{M}_\odot$. Thus, the mechanism(s) responsible for quenching central galaxies plays a crucial role in galaxy evolution as whole. We combine a high resolution cosmological $N$-body simulation with observed evolutionary trends of the "star formation main sequence," quiescent fraction, and stellar mass function at $z < 1$ to construct a model that statistically tracks the star formation histories and quenching of central galaxies. Comparing this model to the distribution of central galaxy star formation rates in a group catalog of the SDSS Data Release 7, we constrain the timescales over which physical processes cease star formation in central galaxies. Over the stellar mass range $10^{9.5}$ to $10^{11} \mathrm{M}_\odot$ we infer quenching e-folding times that span $1.5$ to $0.5\; \mathrm{Gyr}$ with more massive central galaxies quenching faster. For $\mathcal{M}_* = 10^{10.5}\mathrm{M}_\odot$, this implies a total migration time of $\sim 4~\mathrm{Gyrs}$ from the star formation main sequence to quiescence. Compared to satellites, central galaxies take $\sim 2~\mathrm{Gyrs}$ longer to quench their star formation, suggesting that different mechanisms are responsible for quenching centrals versus satellites. Finally, the central galaxy quenching timescale we infer provides key constraints for proposed star formation quenching mechanisms. Our timescale is generally consistent with gas depletion timescales predicted by quenching through strangulation. However, the exact physical mechanism(s) responsible for this still remain unclear.Comment: 16 pages, 11 figure

Foam rigidized inflatable structural assemblies

An inflatable and rigidizable structure for use as a habitat or a load bearing structure is disclosed. The structure consists of an outer wall and an inner wall defining a containment member and a bladder. The bladder is pressurized to erect the structure from an initially collapsed state. The containment member is subsequently injected with rigidizable fluid through an arrangement of injection ports. Exhaust gases from the curing rigidizable fluid are vented through an arrangement of exhaust ports. The rate of erection can be controlled by frictional engagement with a container or by using a tether. A method for fabricating a tubular structure is disclosed

Cosmological Constraints from Galaxy Clustering and the Mass-to-Number Ratio of Galaxy Clusters

We place constraints on the average density (Omega_m) and clustering amplitude (sigma_8) of matter using a combination of two measurements from the Sloan Digital Sky Survey: the galaxy two-point correlation function, w_p, and the mass-to-galaxy-number ratio within galaxy clusters, M/N, analogous to cluster M/L ratios. Our w_p measurements are obtained from DR7 while the sample of clusters is the maxBCG sample, with cluster masses derived from weak gravitational lensing. We construct non-linear galaxy bias models using the Halo Occupation Distribution (HOD) to fit both w_p and M/N for different cosmological parameters. HOD models that match the same two-point clustering predict different numbers of galaxies in massive halos when Omega_m or sigma_8 is varied, thereby breaking the degeneracy between cosmology and bias. We demonstrate that this technique yields constraints that are consistent and competitive with current results from cluster abundance studies, even though this technique does not use abundance information. Using w_p and M/N alone, we find Omega_m^0.5*sigma_8=0.465+/-0.026, with individual constraints of Omega_m=0.29+/-0.03 and sigma_8=0.85+/-0.06. Combined with current CMB data, these constraints are Omega_m=0.290+/-0.016 and sigma_8=0.826+/-0.020. All errors are 1-sigma. The systematic uncertainties that the M/N technique are most sensitive to are the amplitude of the bias function of dark matter halos and the possibility of redshift evolution between the SDSS Main sample and the maxBCG sample. Our derived constraints are insensitive to the current level of uncertainties in the halo mass function and in the mass-richness relation of clusters and its scatter, making the M/N technique complementary to cluster abundances as a method for constraining cosmology with future galaxy surveys.Comment: 23 pages, submitted to Ap

Inflatable Tubular Structures Rigidized with Foams

Inflatable tubular structures that have annular cross sections rigidized with foams, and the means of erecting such structures in the field, are undergoing development. Although the development effort has focused on lightweight structural booms to be transported in compact form and deployed in outer space, the principles of design and fabrication are also potentially applicable to terrestrial structures, including components of ultralightweight aircraft, lightweight storage buildings and shelters, lightweight insulation, and sales displays. The use of foams to deploy and harden inflatable structures was first proposed as early as the 1960s, and has been investigated in recent years by NASA, the U.S. Air Force Research Laboratory, industry, and academia. In cases of deployable booms, most of the investigation in recent years has focused on solid cross sections, because they can be constructed relatively easily. However, solid-section foam-filled booms can be much too heavy for some applications. In contrast, booms with annular cross sections according to the present innovation can be tailored to obtain desired combinations of stiffness and weight through choice of diameters, wall thicknesses, and foam densities. By far the most compelling advantage afforded by this innovation is the possibility of drastically reducing weights while retaining or increasing the stiffnesses, relative to comparable booms that have solid foamfilled cross sections. A typical boom according to this innovation includes inner and outer polyimide film sleeves to contain foam that is injected between them during deployment

Angular Momentum Evolution of Stars in the Orion Nebula Cluster

(Abridged) We present theoretical models of stellar angular momentum evolution from the Orion Nebula Cluster (ONC) to the Pleiades and the Hyades. We demonstrate that observations of the Pleiades and Hyades place tight constraints on the angular momentum loss rate from stellar winds. The observed periods, masses and ages of ONC stars in the range 0.2--0.5 M$_\odot$, and the loss properties inferred from the Pleiades and Hyades stars, are then used to test the initial conditions for stellar evolution models. We use these models to estimate the distribution of rotational velocities for the ONC stars at the age of the Pleiades (120 Myr). The modeled ONC and observed Pleiades distributions of rotation rates are not consistent if only stellar winds are included. In order to reconcile the observed loss of angu lar momentum between these two clusters, an extrinsic loss mechanism such as protostar-accretion disk interaction is required. Our model, which evolves the ONC stars with a mass dependent saturation threshold normalized such that $\omega_{crit} = 5.4 \omega_\odot$ at 0.5 \m, and which includes a distribution of disk lifetimes that is uniform over the range 0--6 Myr, is consistent with the Pleiades. This model for disk-locking lifetimes is also consistent with inferred disk lifetimes from the percentage of stars with infrared excesses observed in young clusters. Different models, using a variety of initial period distributions and different maximum disk lifetimes, are also compared to the Pleiades. For disk-locking models that use a uniform distribution of disk lifetimes over the range 0 to $\tau_{max}$, the acceptable range of the maximum lifetime is $3.5 < \tau_{max} < 8.5$ Myr.Comment: 21 pages, 7 figures, submitted to Ap

Cash Farm Income, 1983-88: A Period of Phenomenal Growth

Exact date of working paper unknown