FAM5C Contributes to Aggressive Periodontitis

Abstract Aggressive periodontitis is characterized by a rapid and severe periodontal destruction in young systemically healthy subjects. A greater prevalence is reported in Africans and African descendent groups than in Caucasians and Hispanics. We first fine mapped the interval 1q24.2 to 1q31.3 suggested as containing an aggressive periodontitis locus. Three hundred and eighty-nine subjects from 55 pedigrees were studied. Saliva samples were collected from all subjects, and DNA was extracted. Twenty-one single nucleotide polymorphisms were selected and analyzed by standard polymerase chain reaction using TaqMan chemistry. Non-parametric linkage and transmission distortion analyses were performed. Although linkage results were negative, statistically significant association between two markers, rs1935881 and rs1342913, in the FAM5C gene and aggressive periodontitis (p = 0.03) was found. Haplotype analysis showed an association between aggressive periodontitis and the haplotype A-G (rs1935881-rs1342913; p = 0.009). Sequence analysis of FAM5C coding regions did not disclose any mutations, but two variants in conserved intronic regions of FAM5C, rs57694932 and rs10494634, were found. However, these two variants are not associated with aggressive periodontitis. Secondly, we investigated the pattern of FAM5C expression in aggressive periodontitis lesions and its possible correlations with inflammatory/immunological factors and pathogens commonly associated with periodontal diseases. FAM5C mRNA expression was significantly higher in diseased versus healthy sites, and was found to be correlated to the IL-1b, IL-17A, IL-4 and RANKL mRNA levels. No correlations were found between FAM5C levels and the presence and load of red complex periodontopathogens or Aggregatibacter actinomycetemcomitans. This study provides evidence that FAM5C contributes to aggressive periodontitis

A integralidade da atenção em diabéticos com doença periodontal The integrality of the attention in diabetics with periodontal disease

O objetivo deste estudo foi avaliar como está organizado o atendimento aos indivíduos com diabetes melito, usuários do SUS, a partir dos dados das condições periodontais apresentadas por este grupo, em Belo Horizonte (MG). Para tanto, uma amostra representativa de trezentos indivíduos foi selecionada para avaliação clínica e entrevista. Foram realizadas entrevistas também com os gerentes de unidades de saúde. Dos avaliados, 55% apresentaram gengivite, 35,3%, periodontite e 9,7% eram saudáveis. Em relação à integralidade da atenção ao diabético no SUS, pôde-se observar que, apesar da maioria estar sob acompanhamento médico, somente 27,3% estavam sob tratamento odontológico na rede básica, 3,6% recebiam atendimento especializado em odontologia e apenas 3,4% eram atendidos por outros profissionais da saúde. O atendimento interdisciplinar e a atenção em todos os níveis do sistema são fatores essenciais para a integralidade das ações em saúde.<br>The aim of this study was to evaluate the periodontal conditions of individuals with diabetes and to analyze how SUS has contributed to the health attention of these people in Belo Horizonte, Minas Gerais State. For that, a sample of 300 individuals was selected and interviews with diabetics and health unit managers were conducted. From those, 55% presented gingivitis, 35.3% periodontitis and 9.7% were healthy. As for the integral attention for diabetics in SUS, it was observed that despite the fact that most of them were under medical supervision, only 27.3% were under dental treatment in basic health care units, 3.6% had specialized dental care and only 3.4% were seen by other health workers. Interdisciplinary care and attention in all levels of the system are essential factors for the integrality of health actions