Attitudes of Higher Education students to new venture creation: a preliminary approach to the Portuguese case

Institutions of higher education have an important role in the generation of high tech ‘entrepreneurial capacity’. Being entrepreneurship in Portugal an emergent phenomenon there is an urgent need to better understand and develop this area not only by analysing the ‘supply side’ (i.e., the courses taught in this field) but also the ‘demand side’, that is, the attitudes of students, future potential entrepreneurs, to new venture creation. Based on 4413 responses of students enrolled in Portuguese higher education institutions, gathered in June-July 2008, we found, using a multivariate model, that students who had already created a firm although, on average, possess larger entrepreneurial experience and knowledge, they do not reveal high risk propensity or creativity. Those students that have taken some steps to create new businesses and, to a larger extent, those foreseeing their future career as owning their business have higher risk and creative profiles. Students who live in an environment which ‘breads’ entrepreneurship have stronger desire to become entrepreneurs. This supports the contention that entrepreneurship is a learned process and that school, teachers, and other institutions and individuals may encourage entrepreneurial behaviours. ‘Role models’ seem indeed to constitute a key factor fostering entrepreneurship among Portuguese higher education students – in the Portuguese case, the entrepreneur and entrepreneurial company references are, respectively, Belmiro de Azevedo and Sonae. Although in a descriptive analysis students enrolled in non-university (e.g., polytechnics) and private higher education institutions reveal higher effective and potential entrepreneurial propensities, when we (simultaneously) control for a vast number of factors which are likely to affect entrepreneurship propensity, such differences cease to be statistically relevant. Students’ personality (risk, creativity) and demographic traits (gender and age), competencies and familiarity with entrepreneurship (entrepreneurial experience, knowledge, awareness, interest), and contextual factors (professional experience, role models) are important determinants of entrepreneurial propensity, whereas the type of higher education institutions (public vs private, non-university vs university), and, to some extent, the degree (postgraduate vs undergraduate), and the scientific area, fail to emerge as key determinants.students; entrepreneurship; attitudes

La universidad en el 2040

Ciento cincuenta expertos y representantes de la educación superior, la empresa y los gobiernos esbozaron en las distintas ediciones del libro The Futures of Universities Thoughtbook cuáles pueden ser las funciones de la universidad en el horizonte de 2040. En este artículo se analizan cinco roles u objetivos estratégicos de la universidad, necesarios para repensar su papel a medio y largo plazo, y seguir poniendo el conocimiento científico, la tecnología innovadora y el capital humano al servicio de la sociedad

Specific DNA structural attributes modulate platinum anticancer drug site selection and cross-link generation

Heavy metal compounds have toxic and medicinal potential through capacity to form strong specific bonds with macromolecules, and the interaction of platinum drugs at the major groove nitrogen atom of guanine bases primarily underlies their therapeutic activity. By crystallographic analysis of transition metal–and in particular platinum compound–DNA site selectivity in the nucleosome core, we establish that steric accessibility, which is controlled by specific structural parameters of the double helix, modulates initial guanine–metal bond formation. Moreover, DNA conformational features can be linked to both similarities and distinctions in platinum drug adduct formation between the naked and nucleosomal DNA states. Notably, structures that facilitate initial platinum–guanine bond formation can oppose cross-link generation, rationalizing the occurrence of long-lived therapeutically ineffective monofunctional adducts. These findings illuminate DNA structure-dependent reactivity and provide a novel framework for understanding metal–double helix interactions, which should facilitate the development of improved chromatin-targeting medicinal agents

Wirtschafts-Wissenschaftskooperationen an Fachhochschulen in Europa

Dieser Beitrag zeigt Ergebnisse einer Studie zu Wissenschafts-Wirtschaftskooperationen (WWK) in Europa, die 2011 für die Europäische Kommission durchgeführt wurde. Alle Hochschulen in 33 EU+-Ländern wurden einbezogen, ein Rücklauf von 6.280 vollständigen Interviews erzielt. WWK werden durch Faktoren beeinflusst, die die Wahrnehmung von Nutzen sowie von Barrieren und Treibern beinhalten. Auch situative Faktoren beeinflussen deren Ausmaß und Umfang. WWK können durch adäquate Strategien, Strukturen und Ansätze, operationale Aktivitäten sowie unterstützende Rahmenbedingungen verstärkt werden. Ein Modell wird vorgestellt, dass das Beziehungsgeflecht der verschie­denen Elemente innerhalb der WWK darstellt. Der Beitrag präsentiert einige detaillierte Ergebnisse zu Fachhochschulen in Europa. 30.03.2012 | Thomas Baaken (Münster) & Todd Davey (Münster/Amsterdam

Understanding polypharmacy for people receiving home care services: a scoping review of the evidence

Background: Polypharmacy, defined as the concurrent use of five or more medications, is common amongst older adults receiving home care services. The relationship between home care and polypharmacy may be critical to older people’s health, but there is little research on this topic. Objective: To understand the extent and type of evidence on individuals receiving home care services and experiencing polypharmacy. Methods: This review followed the Preferred Reporting of Items for Systematic Reviews and Meta-Analyses extension for scoping reviews. Three databases (MEDLINE, Embase, CINAHL) were systematically searched (December 2023) to identify studies with adult participants experiencing polypharmacy and receiving home care. Results: Twenty-three studies were included. For individuals receiving home care services, the studies reported on the following: (i) prevalence of polypharmacy, (ii) interventions to reduce inappropriate polypharmacy, (iii) perceived role of home care workers, (iv) assessment of health literacy in individuals experiencing polypharmacy, and (v) factors associated with polypharmacy and potentially inappropriate medications (PIMs). Polypharmacy and PIMs were found to be associated with older age, female sex, increased frailty, living alone, poor economic situation and inaccuracies within medical records. Improved appropriateness of prescribing can be achieved through interprofessional interventions, efficient use of home care workers and improved health literacy. Conclusion: This review highlights research on the extent of polypharmacy in home care and ways to address it. Whilst there are suggestions for enhancing medication quality, key gaps remain in research into the experiences of care staff and recipients in managing medications and polypharmacy, which should be addressed

Russian roulette with unlicensed fat-burner drug 2,4-dinitrophenol (DNP) : evidence from a multidisciplinary study of the internet, bodybuilding supplements and DNP users

BACKGROUND: 2,4-Dinitrophenol (DNP) poses serious health-risks to humans. The aims of this three-stage multidisciplinary project were, for the first time, to assess the risks to the general public from fraudulent sale of or adulteration/contamination with DNP; and to investigate motives, reasons and risk-management among DNP-user bodybuilders and avid exercisers. METHODS: Using multiple search-engines and guidance for Internet research, online retailers and bodybuilding forums/blogs were systematically explored for availability of DNP, advice offered on DNP use and user profiles. Ninety-eight pre-workout and weight-loss supplements were purchased and analysed for DNP using liquid-chromatography-mass-spectrometry. Psychosocial variables were captured in an international sample of 35 DNP users (26.06 ± 6.10 years, 94.3 % male) with an anonymous, semi-qualitative self-reported survey. RESULTS: Although an industrial chemical, evidence from the Internet showed that DNP is sold 'as is', in capsules or tablets to suit human consumption, and is used 'uncut'. Analytical results confirmed that DNP is not on the supplement market disguised under fictitious supplement names, but infrequently was present as contaminant in some supplements (14/98) at low concentration (<100mcg/kg). Users make conscious and 'informed' decisions about DNP; are well-prepared for the side-effects and show nonchalant attitude toward self-experimentation with DNP. Steps are often taken to ensure that DNP is genuine. Personal experience with performance- and appearance enhancing substances appears to be a gateway to DNP. Advice on DNP and experiences are shared online. The significant discrepancy between the normative perception and the actual visibility suggests that DNP use is-contrary to the Internet accounts-a highly concealed and lonesome activity in real life. Positive experiences with the expected weight-loss prevail over the negative experiences from side effects (all but two users considered using DNP again) and help with using DNP safely is considered preferable over scare-tactics. CONCLUSION: Legislation banning DNP sale for human consumption protects the general public but DNP is sold 'as is' and used 'uncut' by determined users who are not dissuaded from experimenting with DNP based on health threats. Further research with stakeholders' active participation is imperative for targeted, proactive public health policies and harm-reduction measures for DNP, and other illicit supplements

A review on broodstock nutrition of marine pelagic spawners: the curious case of the freshwater eels (Anguilla spp.)

To sustain eel aquaculture, development of reproduction in captivity is vital. The aim of this review is to assess our current knowledge on the nutrition of broodstock eels in order to improve the quality of broodstock under farming conditions, drawing information from wild adult eels and other marine pelagic spawners. Freshwater eels spawn marine pelagic eggs with an oil droplet (type II), and with a large perivitelline space. Compared with other marine fish eggs, eel eggs are at the extreme end of the spectrum in terms of egg composition, even within this type II group. Eel eggs contain a large amount of total lipids, and a shortage of neutral lipids has been implied a cause for reduced survival of larvae. Eel eggs have higher ARA but lower EPA and DHA levels than in other fish. Too high levels of ARA negatively affected reproduction in the Japanese eel, although high levels of 18:2n-6 in the eggs of farmed eels were not detrimental. The total free amino acid amount and profile of eel eggs appears much different from other marine pelagic spawners. Nutritional intervention to influence egg composition seems feasible, but responsiveness of farmed eels to induced maturation might also require environmental manipulation. The challenge remains to succeed in raising European eel broodstock with formulated feeds and to enable the procurement of viable eggs and larvae, once adequate protocols for induced maturation have been developed

University-Business Cooperation and Entrepreneurship at Universities – An Empirical Based Comparison of Poland and Germany

The EU’s growth strategy for the coming decade (recorded and defined by Horizon2020) and the higher education modernisation agenda force all European countries to establish a more connected and better functioning relationship between the three most important players government, business and higher education institutions (HEI’s) in order to increase employment, productivity and social cohesion. This article explores the development of University-Business Cooperation (UBC) both in Poland and in Germany, shining a spotlight on the various factors influencing UBC, as well as providing a comparison of the two countries. The focus lays on a Polish-German comparison i.e. the compared analyses of the state of UBC in Germany and Poland from the perspective of HEI managers and researchers. Applying a UBC-ecosystem of different factors and action levels (http://ub-cooperation.eu/pdf/ UBCECO.pdf) the major differences of both countries are identified, addressed and commented to offer opportunities for improvements. This paper describes and discusses selected findings of a study, which had been conducted for the European Commission to analyse University-Business Cooperation in 33 European countries by the S2B Marketing Research Centre at Münster University of Applied Sciences.Thomas Baaken: [email protected] Rossano, M.A.: [email protected] von Hagenr: [email protected] Davey: [email protected] Meerman: [email protected]. Dr. hab. 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Reconstruction of primary vertices at the ATLAS experiment in Run 1 proton–proton collisions at the LHC

This paper presents the method and performance of primary vertex reconstruction in proton–proton collision data recorded by the ATLAS experiment during Run 1 of the LHC. The studies presented focus on data taken during 2012 at a centre-of-mass energy of √s=8 TeV. The performance has been measured as a function of the number of interactions per bunch crossing over a wide range, from one to seventy. The measurement of the position and size of the luminous region and its use as a constraint to improve the primary vertex resolution are discussed. A longitudinal vertex position resolution of about 30μm is achieved for events with high multiplicity of reconstructed tracks. The transverse position resolution is better than 20μm and is dominated by the precision on the size of the luminous region. An analytical model is proposed to describe the primary vertex reconstruction efficiency as a function of the number of interactions per bunch crossing and of the longitudinal size of the luminous region. Agreement between the data and the predictions of this model is better than 3% up to seventy interactions per bunch crossing