Reviews

Managing Change in Higher Education: A Learning Environment Architecture by Peter Ford and eight other authors, Buckingham: Society for Research into Higher Education and the Open University Press, 1996. ISBN 0–335–19791–4. 161 pages, paperback. No price indicated

Zika virus infection in the returning traveller: what every neurologist should know

Zika virus has been associated with a wide range of neurological complications. Neurologists in areas without current active transmission of the virus may be confronted with Zika-associated neurological disease, as a large number of returning travellers with Zika virus infection have been reported and the virus continues to spread to previously unaffected regions. This review provides an overview of Zika virus-associated neurological disease and aims to support neurologists who may encounter patients returning from endemic areas

CRISPR-TSKO : a technique for efficient mutagenesis in specific cell types, tissues, or organs in Arabidopsis

Detailed functional analyses of many fundamentally important plant genes via conventional loss-of-function approaches are impeded by the severe pleiotropic phenotypes resulting from these losses. In particular, mutations in genes that are required for basic cellular functions and/or reproduction often interfere with the generation of homozygous mutant plants, precluding further functional studies. To overcome this limitation, we devised a clustered regularly interspaced short palindromic repeats (CRISPR)-based tissue-specific knockout system, CRISPR-TSKO, enabling the generation of somatic mutations in particular plant cell types, tissues, and organs. In Arabidopsis (Arabidopsis thaliana), CRISPR-TSKO mutations in essential genes caused well-defined, localized phenotypes in the root cap, stomatal lineage, or entire lateral roots. The modular cloning system developed in this study allows for the efficient selection, identification, and functional analysis of mutant lines directly in the first transgenic generation. The efficacy of CRISPR-TSKO opens avenues for discovering and analyzing gene functions in the spatial and temporal contexts of plant life while avoiding the pleiotropic effects of system-wide losses of gene function

Implementing community-based participatory research in the study of substance use and service utilisation in Eastern European and Turkish communities in Belgium

Community-Based Participatory Research (CBPR) is an effective strategy to promote action research regarding health and substance use issues. The London-based Centre for Ethnicity and Health's CBPR model was replicated in Belgium to study substance use and service utilisation in Bulgarian, Slovakian and Turkish communities in the city of Ghent. This article focuses on the implementation of the CBPR model, challenges and adaptions linked to the Belgian context. In this paper, we describe the study design and actors involved, namely (1) community organisations, (2) the community advisory board and (3) community researchers. Furthermore, we focus on the challenges and pitfalls of the CBPR method and its implications, including (1) community collaboration, (2) co-ethnic researchers, (3) characteristics of the respondents and (4) empowerment of the respective communities. We conclude by discussing potential pathways for future CBPR in the field of substance use and service utilisation among migrants and ethnic minorities

Growing apple (Malus domestica) under tropical mountain climate conditions in Northern Ethiopia

Lack of effective chilling during the dormant season is one of the major problems when apples are growing under a tropical climate. We evaluated the response of different apple cultivars (Golden Delicious, Gala, Fuji, Granny Smith and Jonagold) grown on M9 rootstock with different dormancy-management practices. The trials were carried out between 2004 and 2006 in a tropical mountain area (Tigray, Ethiopia), where chilling conditions are poor with the aim of improving and synchronizing the bud break and the blossoming period of these apple cultivars. Two-year-old well-feathered trees were planted in two experimental trial sites in it randomized complete block design. Trees were subjected to the following treatments in two sets of experiments: one defoliation per year only; two defoliations per year, one defoliation followed by 1% hydrogen cyanamide (Dormex) treatment; one defoliation followed by 2% Dormex treatment; one defoliation followed by 40% winter oil; one defoliation followed by 0.5% Dormex and 2% winter oil; and a control with no defoliation or dormancy breaking treatments. The result show positive effects of the dormancy breaking agents oil the productivity of the trees after defoliation, with comparable results for the effectiveness of both Dormex and winter oil. There were On statistically significant differences between the Dormex closes. The defoliation treatment alone Was not sufficient to break dormancy for the cultivars Golden Delicious, Granny Smith or Gala but showed promising results with dormancy breaking Jonagold. Yields increased as a result of better flowering time synchronization within a tree but even with the dormancy treatments the length of the flowering period was still spread over five weeks, where under it more temperate climate it lasted two to three weeks. The average fruit weight of Jonagold and Granny Smith can be considered as it good fruit quality while the fruit of other diploid cultivars like Golden, Gala and Fuji were rather small, which indicates chat fruit thinning by hand will be it necessity For these cultivars. Red colouration of the apples oil the cultivars Gala and Jonagold was excellent and meets the standards necessary for commercialization of these fruits. The sugar concentration of the fruits and the fruit firmness at harvest was high. The results of these first trials indicate that it is possible to develop new apple production in the mountain region of Tigray, Ethiopia

Heat Island Mitigation Assessment and Policy Development for the Kansas City Region

Lawrence Berkeley National Laboratory partnered with Mid-America Regional Council (MARC) to quantify the costs and benefits from the adoption of urban heat island (UHI) countermeasures in the Kansas City region (population 1.5 million), and identify the best regional implementation pathway for MARC. The team selected cool (high-albedo) roofs and increased vegetation as the two countermeasures to evaluate. For vegetation, there were two strategies: (1) planting new trees to shade building surfaces, and (2) increasing urban irrigation (a surrogate for the use of vegetation to manage stormwater) to increase evapotranspiration. Using the Weather Research and Forecasting (WRF) model we simulated selected weeks during summer time, across five years (2011 2015) representing a range of normal summer conditions. We also simulated six of the most intense heatwaves that occurred between 2004 and 2016. We found under typical summer conditions (non-heatwave) average daytime (07:00 19:00 local standard time) regional near-ground air temperature reductions of 0.08 and 0.28 C for cool roofs and urban irrigation, respectively. We calculated the building electricity, electricity cost, and emission savings that result from the reduction in outdoor air temperature (indirect savings) and found maximum regional annual indirect electricity savings of 42.8 GWh for cool roofs and 85.6 GWh for urban irrigationyielding maximum regional annual indirect electricity cost savings of $5.6M ($0.05/m2 roof) and $11.1M ($0.01/m2 irrigated land), respectively, and maximum regional annual CO2 savings of 43.4 kt and 80 kt, respectively.We next evaluated the building energy, energy cost, and emission savings from reducing direct absorbed radiation on the building surfaces using cool roofs and shade trees (direct savings). For cool roofs, we found regional annual direct energy cost savings of $10.9M ($0.15/m2 roof) with regional annual CO2 savings of 66.4 kt. For shade trees, the regional annual direct energy cost savings were $21M ($21/tree) with regional annual CO2 savings of 126 kt. We investigated cool roof cost premiums (the additional cost for selecting a cool roof product in lieu of a conventional roof product, estimated to be zero to $2.15/m2) and shade tree first costs (assumed to be$100 per tree). The regional cool roof cost premium was calculated using the regional roof area per roofing material type and the range of cool roof product premiums for each material type. The extra cost of selecting cool roofs across the region ranged from $4.33M to$87.1M, while the additional shade trees planted across the region were assumed to cost $102M. When we compared the regional annual direct cost savings to the regional cool-roof cost premium and the regional shade-tree first cost, we found regional simple payback times up to 8.0 years for cool roofs and 4.9 years for trees, respectively.Since this comprehensive assessment of UHI countermeasures is a valuable methodology for other local governments to apply, we developed a step-by-step guide for others to follow. Based on the benefits and costs of the UHI countermeasures, MARC will pursue the inclusion of these countermeasures in existing regional plans where they can complement other regional priorities for transportation, climate resiliency, clean air, and hazard mitigation. They hosted a local workshop in 2016 for stakeholders to introduce the topic and will continue to share these resources to further appropriate adoption of UHI countermeasures