An Information System's Jabber/XMPP Gateway as a Web Service

Cílem práce je seznámit se s protokolem XMPP a s webovými službami a vytvořit webovou službu, která umožní komunikaci s uživatelem pomocí XMPP zpráv.The objective of this thesis was to learn about XMPP protocol and web services and to create a web service that provides communication with the user through XMPP messages.

Influence of the initial imperfections with regard to the webs thicknesses of cold-formed compressed steel members

Local stability requirements related to unfavorable buckling effects of compressed parts of cold-formed profiles are highly significant. Favorable effects related to their post-critical behavior are also important. The paper deals with resistance of these type of members, taking into account the influence of initial imperfections with regard to the thicknesses of their webs. The paper also presents information about experimental and theoretical-numerical research to determine the resistance of cold-formed compressed steel members with closed cross-sections. Obtained results are very extensive; therefore the paper presents results of part of tested and analyzed member

Application of the extraction by EDTA acid on gravitation dust sediment samples from the Koice industrial region

This work is focused on the experimental determination of the effect of extraction time and pH of the 0.05 M EDTA on the extraction degree of selected elements. It has been determined that the pH of 0.05 M EDTA = 7 as specified by the norm is possible to be used for the extraction of the dust sediment but the 1-hour extraction is not satisfactory for the isolation of all mobilizable elements forms

Ambulatory assessment of physiological arousal, emotion, and alcohol use

Research examining whether negative affect leads to drinking has produced mixed results (Greeley and Oei, 1999; Sher and Grekin, 2007). The current project enlisted participants (n=43) oversampled for affective instability, arguably making them at higher risk for negative affect-driven alcohol consumption. The goals of this study were to 1) validate an ambulatory device for measuring electrodermal activity (EDA) and to 2) examine the relations between emotion, EDA, and alcohol use in real-time. Multiple self-reports of emotion, alcohol use, and behavior were obtained from participants each day over the course of one week using electronic diaries. EDA was assessed continuously during waking hours. The results suggested that ambulatory measurement of EDA is feasible, and agreement between ambulatory measures and traditional laboratory measures was moderate to high for number of skin conductance responses per minute. Skin conductance level was less consistent across measures. With regard to ambulatory findings, high negative affect and high arousal states during the day were generally related to decreased likelihood of same-day drinking and decreased estimated blood alcohol concentration, while positive affect was related to increased likelihood of drinking. Hostility and number of skin conductance responses interacted, such that low hostility and low arousal was related to greater amounts of alcohol consumed. In sum, negative affect and arousal were related to alcohol use in real-time, but effects were small and both were generally protective against alcohol consumption at the day-level. This study helps to clarify the role of arousal in affect-related drinking, while also adding to accumulating evidence that suggests negative affect-related drinking may not be an immediate coping response. Positive-affect drinking may be most relevant in early stages of alcohol use, even in an emotionally dysregulated sample

Beyond pain management: A primer for providing quality end-of-life care

Providing excellent care for a dying patient is something all patients deserve. Hospices and palliative care centers exist in many areas to aid primary care physicians and patients through this difficult time. It is important to remember that most patients want to prepare for death, if at all possible. Everyone does this in his or her own way, but oftentimes concern about pain and symptom management interfere with this very involved and valuable process. Being prepared to treat these symptoms as well as addressing your patient\u27s emotional needs is imperative. Referral to a hospice, if possible, will only strengthen the support available to the patient, the family, and you, the primary care physician. In the end, there is much that we have to offer a dying patient. Efforts should not stop because the illness cannot be cured. So much can happen to someone in the window of time between terminal diagnosis and death. Making this period one in which a person is as mentally clear, physically comfortable, and symptom free for as long as possible is a goal that is worthy of our efforts

Srs2 Disassembles Rad51 Filaments by a Protein-Protein Interaction Triggering ATP Turnover and Dissociation of Rad51 from DNA

Rad51 is a DNA recombinase functioning in the repair of DNA double-strand breaks and the generation of genetic diversity by homologous recombination (HR). In the presence of ATP, Rad51 self-assembles into an extended polymer on single-stranded DNA to catalyze strand exchange. Inappropriate HR causes genomic instability, and it is normally prevented by remodeling enzymes that antagonize the activities of Rad51 nucleoprotein filaments. In yeast, the Srs2 helicase/translocase suppresses HR by clearing Rad51 polymers from single-stranded DNA. We have examined the mechanism of disassembly of Rad51 nucleoprotein filaments by Srs2 and find that a physical interaction between Rad51 and the C-terminal region of Srs2 triggers ATP hydrolysis within the Rad51 filament, causing Rad51 to dissociate from DNA. This allosteric mechanism explains the biological specialization of Srs2 as a DNA motor protein that antagonizes HR