An optimal control approach to malaria prevention via insecticide-treated nets

Malaria is a life threatening disease, entirely preventable and treatable, provided the currently recommended interventions are properly implemented. These interventions include vector control through the use of insecticide-treated nets (ITNs). However, ITN possession does not necessarily translate into use. Human behavior change interventions, including information, education, communication (IEC) campaigns and post-distribution hang-up campaigns are strongly recommended. In this paper we consider a recent mathematical model for the effects of ITNs on the transmission dynamics of malaria infection, which takes into account the human behavior. We introduce in this model a supervision control, representing IEC campaigns for improving the ITN usage. We propose and solve an optimal control problem where the aim is to minimize the number of infectious humans while keeping the cost low. Numerical results are provided, which show the effectiveness of the optimal control interventions.Comment: This is a preprint of a paper whose final and definite form will appear in Conference Papers in Mathematics, Volume 2013, Article ID 658468, http://dx.doi.org/10.1155/2013/658468. Paper Submitted 10-May-2013; accepted after minor revision 09-June-201

A stochastic SICA epidemic model for HIV transmission

We propose a stochastic SICA epidemic model for HIV transmission, described by stochastic ordinary differential equations, and discuss its perturbation by environmental white noise. Existence and uniqueness of the global positive solution to the stochastic HIV system is proven, and conditions under which extinction and persistence in mean hold, are given. The theoretical results are illustrated via numerical simulations.Comment: This is a preprint of a paper whose final and definite form is with 'Applied Mathematics Letters', ISSN 0893-9659. Submitted 22/Jan/2018; Revised 03/May/2018; Accepted for publication 03/May/201

Two-dimensional Newton's problem of minimal resistance

Newton's problem of minimal resistance is one of the first problems of optimal control: it was proposed, and its solution given, by Isaac Newton in his masterful Principia Mathematica, in 1686. The problem consists of determining, in dimension three, the shape of an axis-symmetric body, with assigned radius and height, which offers minimum resistance when it is moving in a resistant medium. The problem has a very rich history and is well documented in the literature. Of course, at a first glance, one suspects that the two dimensional case should be well known. Nevertheless, we have looked into numerous references and asked at least as many experts on the problem, and we have not been able to identify a single source. Solution was always plausible to everyone who thought about the problem, and writing it down was always thought not to be worthwhile. Here we show that this is not the case: the two-dimensional problem is richer than the classical one, being, in some sense, more interesting. Novelties include: (i) while in the classical three-dimensional problem only the restricted case makes sense (without restriction on the monotonicity of admissible functions the problem does not admit a local minimum), we prove that in dimension two the unrestricted problem is also well-posed when the ratio of height versus radius of base is greater than a given quantity; (ii) while in three dimensions the (restricted) problem has a unique solution, we show that in the restricted two-dimensional problem the minimizer is not always unique - when the height of the body is less or equal than its base radius, there exists infinitely many minimizing functions

Quantal distribution functions in non-extensive statistics and an early universe test revisited

Within the context of non-extensive thermostatistics, we use the factorization approximation to study a recently proposed early universe test. A very restrictive bound upon the non-extensive parameter is presented: $|q-1| < 4.01 \times 10^{-3}$.Comment: 4 pages, prl revtex style, no figures. To appear in Physica A, 199

Modeling TB-HIV syndemic and treatment

Tuberculosis (TB) and human immunodeficiency virus (HIV) can be considered a deadly human syndemic. In this article, we formulate a model for TB and HIV transmission dynamics. The model considers both TB and acquired immune deficiency syndrome (AIDS) treatment for individuals with only one of the infectious diseases or both. The basic reproduction number and equilibrium points are determined and stability is analyzed. Through simulations, we show that TB treatment for individuals with only TB infection reduces the number of individuals that become co-infected with TB and HIV/AIDS, and reduces the diseases (TB and AIDS) induced deaths. Analogously, the treatment of individuals with only AIDS also reduces the number of co-infected individuals. Further, TB-treatment for co-infected individuals in the active and latent stage of TB disease, implies a decrease of the number of individuals that passes from HIV-positive to AIDS.Comment: This is a preprint of a paper whose final and definite form is: Journal of Applied Mathematics (ISSN 1110-757X) 2014, Article ID 248407, http://dx.doi.org/10.1155/2014/24840

Optimal Control of Tuberculosis: A Review

We review the optimal control of systems modeling the dynamics of tuberculosis. Time dependent control functions are introduced in the mathematical models, representing strategies for the improvement of the treatment and cure of active infectious and/or latent individuals. Optimal control theory allows then to find the optimal way to implement the strategies, minimizing the number of infectious and/or latent individuals and keeping the cost of implementation as low as possible. An optimal control problem is proposed and solved, illustrating the procedure. Simulations show an effective reduction in the number of infectious individuals.Comment: This is a preprint of a paper whose final and definite form will be published in the volume 'Mathematics of Planet Earth' that initiates the book series 'CIM Series in Mathematical Sciences' (CIM-MS) published by Springer. Submitted Aug 2013; Revised and Accepted June 201

Development of erythematous scaly lesions in a cervical surgical scar

info:eu-repo/semantics/publishedVersio