Brane tilings and supersymmetric gauge theories

In the last few years, brane tilings have proven to be an efficient and convenient way of studying supersymmetric gauge theories living on D3-branes or M2-branes. In these pages we present a quick and simple introduction to the subject, hoping this could tickle the reader's curiosity to learn more on this extremely fascinating subject.Comment: 3 pages, 2 figures, based on a presentation given by G.T. at the 2010 Cargese Summer School (June 21-July 3), to appear in the proceeding

Higgsing M2-brane theories

Accepted versio

Hilbert Series for Flavor Invariants of the Standard Model

The Hilbert series is computed for the lepton flavor invariants of the Standard Model with three generations including the right-handed neutrino sector needed to generate light neutrino masses via the see-saw mechanism. We also compute the Hilbert series of the quark flavor invariants for the case of four generations.Comment: 6 page

Corrigendum to “Pollen-based paleoenvironmental and paleoclimatic change at Lake Ohrid (south-eastern Europe) during the past 500 ka” published in Biogeosciences, 13, 1423–1437, 2016

In this corrigendum we report an updated pollen record from the Lake Ohrid DEEP site spanning the past 500 ka whereby we have reprocessed and re-analyzed 104 samples affected by chemical procedure problems that occurred in one palynological laboratory. Firstly, these samples were affected by the use of wrong containers, causing in- adequate settling of particles at the set centrifuging speed. Secondly, HCl and HF treatments were combined without the prescribed intermediate centrifuging and decanting steps. The inaccuracy in the protocol resulted in the loss of smaller pollen grains and in the overrepresentation of bisaccate ones in most of the re-analyzed samples. We therefore provide an updated set of figures with the new data and have revised the description of the results, discussion and conclusions re- ported in Sadori et al. (2016) where necessary. We stress that the majority of the original results and conclusions remain valid, while the records’ reliability and resolution have improved as 12 samples that had been omitted in the original study because of low count sums are now included in the revised dataset (Sadori et al., 2018)

M2-Branes and Fano 3-folds

A class of supersymmetric gauge theories arising from M2-branes probing Calabi-Yau 4-folds which are cones over smooth toric Fano 3-folds is investigated. For each model, the toric data of the mesonic moduli space is derived using the forward algorithm. The generators of the mesonic moduli space are determined using Hilbert series. The spectrum of scaling dimensions for chiral operators is computed.Comment: 128 pages, 39 figures, 42 table

Neoadjuvant eribulin mesylate following anthracycline and taxane in triple negative breast cancer: Results from the HOPE study

Background Eribulin mesylate (E) is indicated for metastatic breast cancer patients previously treated with anthracycline and taxane. We argued that E could also benefit patients eligible for neoadjuvant chemotherapy. Methods Patients with primary triple negative breast cancer 2 cm received doxorubicin 60 mg/m2 and paclitaxel 200 mg/m2 x 4 cycles (AT) followed by E 1.4 mg/m2 x 4 cycles. Primary endpoint was pathological complete response (pCR) rate; secondary and explorative endpoints included clinical/metabolic response rates and safety, and biomarker analysis, respectively. Using a two-stage Simon design, 43 patients were to be included provided that 4 of 13 patients had achieved pCR in the first stage of the study. Results In stage I of the study 13 women were enrolled, median age 43 years, tumor size 2–5 cm in 9/13 (69%), positive nodal status in 8/13 (61%). Main grade 3 adverse event was neutropenia (related to AT and E in 4 and 2 cases, respectively). AT followed by E induced clinical complete + partial responses in 11/13 patients (85%), pCR in 3/13 (23%). Median measurements of maximum standardized uptake value (SUVmax) resulted 13, 3, and 1.9 at baseline, after AT and E, respectively. Complete metabolic response (CMR) occurred after AT and after E in 2 and 3 cases, respectively. Notably, 2 of the 5 (40%) patients with CMR achieved pCR at surgery. Immunostaining of paired pre-/post-treatment tumor specimens showed a reduction of β-catenin, CyclinD1, Zeb-1, and c-myc expression, in the absence of N-cadherin modulation. The study was interrupted at stage I due to the lack of the required patients with pCR. Conclusions Despite the early study closure, preoperative E following AT showed clinical and biological activity in triple negative breast cancer patients. Furthermore, the modulation of β-catenin pathway core proteins, supposedly outside the domain of epithelial–mesenchymal transition, claims for further investigation. Trial registration EU Clinical Trial Register, EudraCT number 2012-004956-12

ARCRAIDER II: Arc search in a sample of non-Abell clusters

We present a search for gravitational arcs in a sample of X-ray luminous, medium redshift clusters of galaxies. The sample of clusters is called ARCRAIDER, is based on the ROSAT Bright Survey (RBS) and fulfills the following criteria: (a) X-ray luminosity Lx>=0.5x10^45erg/s (0.5-2keV band), (b) redshift range 0.1<=z<=0.52, (c) classified as clusters in the RBS, (d) not a member of the Abell catalogue and, finally, (e) visible from the ESO sites La Silla/Paranal (declination \delta<=20deg). In total we found more than 35 (giant) arc/arclet candidates, including a possible radial arc, one galaxy-galaxy lensing event and a possible quasar triple image in 14 of the 21 clusters of galaxies. Hence 66% of the sample members are possible lenses.Comment: Accepted for publication in Astronomy and Astrophysics; 8 pages (excl. Appendix), 6 figures, 9 tables; Please download the high-res images of the appendix from http://astro-staff.uibk.ac.at/~w.kausch/ARCRAIDER_II_images.tar.g

Phases of M2-brane Theories

We investigate different toric phases of 2+1 dimensional quiver gauge theories arising from M2-branes probing toric Calabi-Yau 4 folds. A brane tiling for each toric phase is presented. We apply the 'forward algorithm' to obtain the toric data of the mesonic moduli space of vacua and exhibit the equivalence between the vacua of different toric phases of a given singularity. The structures of the Master space, the mesonic moduli space, and the baryonic moduli space are examined in detail. We compute the Hilbert series and use them to verify the toric dualities between different phases. The Hilbert series, R-charges, and generators of the mesonic moduli space are matched between toric phases.Comment: 60 pages, 28 figures, 6 tables. v2: minor correction

Cytochrome oxidase subunit VI of Trypanosoma brucei is imported without a cleaved presequence and is developmentally regulated at both RNA and protein levels

Mitochondrial respiration in the African trypanosome undergoes dramatic developmental stage regulation. This requires co-ordinated control of components encoded by both the nuclear genome and the kinetoplast, the unusual mitochondrial genome of these parasites. As a model for understanding the co-ordination of these genomes, we have examined the regulation and mitochondrial import of a nuclear-encoded component of the cytochrome oxidase complex, cytochrome oxidase subunit VI (COXVI). By generating transgenic trypanosomes expressing intact or mutant forms of this protein, we demonstrate that COXVI is not imported using a conventional cleaved presequence and show that sequences at the N-terminus of the protein are necessary for correct mitochondrial sorting. Analyses of endogenous and transgenic COXVI mRNA and protein expression in parasites undergoing developmental stage differentiation demonstrates a temporal order of control involving regulation in the abundance of, first, mRNA and then protein. This represents the first dissection of the regulation and import of a nuclear-encoded protein into the cytochrome oxidase complex in these organisms, which were among the earliest eukaryotes to possess a mitochondrion