New Strategies for Latino Voter Mobilization: The Nevada Democratic Caucus as a Case Study

Describes the 2008 Democratic caucus in Nevada with a focus on the large Hispanic/Latino population. Reviews earlier efforts to raise historically low voter participation rates and the role of the media and suggests new models for voter mobilization

Frontloading the Primaries: African Americans No Longer Marginalized

Outlines how holding Democratic primaries early might affect the representation of African-American voters in a process long dominated by Iowa and New Hampshire. Considers the potential impact on policy issues as well as ways to maximize participation

Calpain 12 function revealed through the study of an atypical case of autosomal recessive congenital ichthyosis

Congenital erythroderma is a rare and often life-threatening condition, which has been shown to result from mutations in several genes encoding important components of the epidermal differentiation program. Using whole exome sequencing, we identified in a child with congenital exfoliative erythroderma, hypotrichosis, severe nail dystrophy and failure to thrive, two heterozygous mutations in ABCA12 (c.2956C&gt;T, p.R986W; c.5778+2T&gt;C, p. G1900Mfs*16), a gene known to be associated with 2 forms of ichthyosis, autosomal recessive congenital ichthyosis and harlequin ichthyosis. Because the patient displayed an atypical phenotype, including severe hair and nail manifestations, we scrutinized the exome sequencing data for additional potentially deleterious genetic variations in genes of relevance to the cornification process. Two mutations were identified in CAPN12, encoding a member of the calpain proteases: a paternal missense mutation (c.1511C&gt;A; p.P504Q) and a maternal deletion due to activation of a cryptic splice site in exon 9 of the gene (c.1090_1129del ; p.Val364Lysfs*11). The calpain 12 protein was found to be expressed in both the epidermis and hair follicle of normal skin but its expression was dramatically reduced in the patient's skin. Down-regulation of capn12 expression in zebrafish was associated with abnormal epidermal morphogenesis. siRNA knockdown of CAPN12 in three-dimensional human skin models was associated with acanthosis, disorganized epidermal architecture and down-regulation of several differentiation markers, including filaggrin. Accordingly, filaggrin expression was almost absent in the patient skin. Using ex vivo live imaging, siRNA knockdown of calpain 12 in skin from K14-H2B GFP mice led to significant hair follicle catagen transformation compared to controls. In summary, our results indicate that calpain 12 plays an essential role during epidermal ontogenesis and normal hair follicle cycling and that its absence may aggravate the clinical manifestations of ABCA12 mutations.</p

KICK BOXING MUSICALIZADO, AGILIDAD Y FÚTBOL DE SALÓN FEMENINO

Introduction: Kick Boxing musicalized, as a fitness regime is a modality of great welcome and acceptance today around the world; It has grown in popularity, since it combines different modalities and cardiovascular elements that allow you to train the body in its entirety and at a high intensity; it consists basically of elements of punches and kicks. Course Objective: Of this research is to identify the effects that the musicalized Kick Boxing generates in the agility of the women's soccer team of the Imdecur (Institute of Sports and Culture) of Chiquinquirá, Methodology: developing a series of 3 weekly sessions for two months that involved the active participation of each of the athletes. The approach to use is quantitative, the design used was quasi-experimental. Ten athletes are part of the research, (13.8 ± 0.7 years) (154.8 ± 4.5 cm) (52.8 ± 4.8 Kg). For the measurement of agility, the Illinois Test was used, which yielded averages of 19.80 and 17.20 sec. in the pre and posttest respectively; generating a percentage improvement of 13.16% at the group level. Results: show that there are significant changes between the pretest and the posttest (p&gt; 0.05); the t-student test was performed with a level of significance α = 0.05; The P-value of the test (Sig. bilateral) is = 0.000. Conclusions: that the effect of the musicalized kick boxing had positive effects on the agility of the players, being able to affirm that the sessions applied improved the agility.Introducción: El Kick Boxing musicalizado, como un régimen de acondicionamiento físico es una modalidad de gran acogida y aceptación en la actualidad alrededor del mundo; ha crecido en popularidad, debido a que, combina diferentes modalidades y elementos cardiovasculares que permiten entrenar el cuerpo en su totalidad y a una alta intensidad; consiste básicamente en elementos como puñetazos y patadas. Objetivo General: Identificar los efectos que el Kick Boxing musicalizado genera en la agilidad del equipo de fútbol de salón femenino del Imdecur (Instituto de Deportes y Cultura) de Chiquinquirá. Metodología: Se desarrollará a través de una serie de 3 sesiones semanales durante dos meses que involucraron la participación activa de cada una de las deportistas. El enfoque a utilizar es cuantitativo, el diseño utilizado fue cuasi-experimental. Hicieron parte de la investigación 10 deportistas: (13,8 ± 0,7 años) (154,8 ± 4,5 cm) (52,8 ± 4,8 Kg). &nbsp;Para la medición de la agilidad se utilizó el Test de Illinois, que con su aplicación produjo promedios de 19,80 y 17,20 segundos en el pre test y pos test respectivamente; generando un porcentaje de mejora de 13,16% a nivel grupal. Los resultados: Muestran que existen cambios significativos entre el pre-test y el pos-test (p &gt; 0,05); la prueba t-student se realizó con un nivel de significancia α = 0,05; el P-valor de la prueba (Sig. bilateral) es =0,000. Conclusiones: El efecto del Kick Boxing musicalizado presentó efectos positivos de la agilidad en las jugadoras, pudiéndose afirmar que las sesiones aplicadas mejoraron la agilidad de manera significativa

Reconstruction of primary vertices at the ATLAS experiment in Run 1 proton–proton collisions at the LHC

This paper presents the method and performance of primary vertex reconstruction in proton–proton collision data recorded by the ATLAS experiment during Run 1 of the LHC. The studies presented focus on data taken during 2012 at a centre-of-mass energy of √s=8 TeV. The performance has been measured as a function of the number of interactions per bunch crossing over a wide range, from one to seventy. The measurement of the position and size of the luminous region and its use as a constraint to improve the primary vertex resolution are discussed. A longitudinal vertex position resolution of about 30μm is achieved for events with high multiplicity of reconstructed tracks. The transverse position resolution is better than 20μm and is dominated by the precision on the size of the luminous region. An analytical model is proposed to describe the primary vertex reconstruction efficiency as a function of the number of interactions per bunch crossing and of the longitudinal size of the luminous region. Agreement between the data and the predictions of this model is better than 3% up to seventy interactions per bunch crossing

Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study

Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world. Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231. Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58·5%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31·2%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10·2%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12·3%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9·4%] of 7339 patients), middle (549 [14·0%] of 3918 patients), and low (298 [23·2%] of 1282) HDI (p < 0·001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17·8%] of 574 patients in high-HDI countries; 74 [31·4%] of 236 patients in middle-HDI countries; 72 [39·8%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1·60, 95% credible interval 1·05–2·37; p=0·030). 132 (21·6%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16·6%) of 295 patients in high-HDI countries, in 37 (19·8%) of 187 patients in middle-HDI countries, and in 46 (35·9%) of 128 patients in low-HDI countries (p < 0·001). Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

Assessing the reach, effectiveness, adoption, implementation, and maintenance of the ProACTIVE SCI physical activity counseling intervention among physiotherapists and SCI peer coaches during the transition from rehabilitation to community

IntroductionPhysical Activity (PA) levels for individuals with spinal cord injury (SCI) peak during rehabilitation and sharply decline post-discharge. The ProACTIVE SCI intervention has previously demonstrated very large-sized effects on PA; however, it has not been adapted for use at this critically understudied timepoint. The objective is to evaluate the reach, effectiveness, adoption, implementation, and maintenance of the ProACTIVE SCI intervention delivered by physiotherapists and SCI peer coaches during the transition from rehabilitation to community.MethodsA single-group, within-subjects, repeated measures design was employed. The implementation intervention consisted of PA counseling training, champion support, prompts and cues, and follow-up training/community of practice sessions. Physiotherapists conducted counseling sessions in hospital, then referred patients to SCI peer coaches to continue counseling for 1-year post-discharge in the community. The RE-AIM Framework was used to guide intervention evaluation.ResultsReach: 82.3% of patients at the rehabilitation hospital were reached by the intervention. Effectiveness: Interventionists (physiotherapists and SCI peer coaches) perceived that PA counseling was beneficial for patients. Adoption: 100% of eligible interventionists attended at least one training session. Implementation: Interventionists demonstrated high fidelity to the intervention. Intervention strategy highlights included a feasible physiotherapist to SCI peer coach referral process, flexibility in timepoint for intervening, and time efficiency. Maintenance: Ongoing training, PA counseling tracking forms, and the ability to refer to SCI peer coaches at discharge are core components needed to sustain this intervention.DiscussionThe ProACTIVE SCI intervention was successfully adapted for use by physiotherapists and SCI peer coaches during the transition from rehabilitation to community. Findings are important for informing intervention sustainability and scale-up

Erratum:Towards a muon collider

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