Einstein: Von Marionette bis Mythos : Annäherung an ein Phänomen

Rezension zu: Michael Hagner (Hrsg.) : Einstein on the beach. Der Physiker als Phänomen ; Fischer Taschenbuch Verlag, Frankfurt, 2005, ISBN 3-5961-6515-6, 326 Seiten, 13,90 Euro

Warum Einstein doch nicht nach Frankfurt kam : ein Brieffund im Universitätsarchiv und die Geschichte der Relativitätstheorie an der Frankfurter Universität

Das liberale Programm der Frankfurter Stiftungsuniversität und der Wille der Sponsoren, auch ungewöhnliche Berufungen, Experimente und Projekte zu fördern, zog ab 1914 innovative Gelehrte aller Disziplinen in die Main-Metropole. Pioniere ihres Fachs nutzten die Gunst der Stunde – so auch in der Physik, wo neben Friedrich Dessauer, dem Wegbreiter der Strahlenbiophysik, bedeutende Naturwissenschaftler die junge und in der wissenschaftlichen Welt noch hoch umstrittene Relativitätstheorie offensiv lehrten und in Experimenten fortführten. Erster Lehrstuhlinhaber für Theoretische Physik war der spätere Nobelpreisträger Max von Laue, ihm folgte mit Max Born ein weiterer Relativitätstheoretiker der ersten Stunde – und immerhin scheint auch Albert Einstein einen Wechsel von der Spree an den Main erwogen zu haben, wie ein erst kürzlich gefundenes Schreiben aus dem Jahr 1920 bestätigt

Habitat Demonstration Unit Medical Operations Workstation Upgrades

This paper provides an overview of the design and fabrication associated with upgrades for the Medical Operations Workstation in the Habitat Demonstration Unit. The work spanned a ten week period. The upgrades will be used during the 2011 Desert Research and Technology Studies (Desert RATS) field campaign. Upgrades include a deployable privacy curtain system, a deployable tray table, an easily accessible biological waste container, reorganization and labeling of the medical supplies, and installation of a retractable camera. All of the items were completed within the ten week period

High-performance Schottky diodes endure high temperatures

Fabrication process and aluminum/GaAs (gallium arsenide) coupling are used to produce Schottky diodes that have high cutoff frequencies and can withstand operating temperatures in excess of 500 C

Functional study of a novel missense single-nucleotide variant of NUP107 in two daughters of Mexican origin with premature ovarian insufficiency.

BackgroundHypergonadotropic hypogonadism (HH) is a genetically heterogeneous disorder that usually presents with amenorrhea, atrophic ovaries, and low estrogen. Most cases of HH are idiopathic and nonsyndromic. Nucleoporin 107 (NUP107), a protein involved in transport between cytoplasm and nucleus with putative roles in meiosis/mitosis progression, was recently implicated as a cause of HH. We identified a NUP107 genetic variant in a nonconsanguineous family with two sisters affected with primary amenorrhea and HH, and generated a mouse model that carried the human variant.MethodsWe performed a high-resolution X-chromosome microarray and whole exome sequencing on parents and two sisters with HH to identify pathogenic variants. We generated a mouse model of candidate NUP107 variant using CRISPR/Cas9.ResultsWhole exome sequencing identified a novel and rare missense variant in the NUP107 gene (c.1063C>T, p.R355C) in both sisters with HH. In order to determine functional significance of this variant, we used CRISPR/Cas9 to introduce the human variant into the mouse genome. Mice with the homolog of the R355C variant, as well as the nine base pairs deletion in Nup107 had female subfertility.ConclusionsOur findings indicate that NUP107 R355C variant falls in the category of variant of unknown significance as the cause of HH and infertility