Genetic modifiers of cognitive maintenance among older adults.

ObjectiveIdentify genetic factors associated with cognitive maintenance in late life and assess their association with gray matter (GM) volume in brain networks affected in aging.MethodsWe conducted a genome-wide association study of ∼2.4 M markers to identify modifiers of cognitive trajectories in Caucasian participants (N = 7,328) from two population-based cohorts of non-demented elderly. Standardized measures of global cognitive function (z-scores) over 10 and 6 years were calculated among participants and mixed model regression was used to determine subject-specific cognitive slopes. "Cognitive maintenance" was defined as a change in slope of ≥ 0 and was compared with all cognitive decliners (slope < 0). In an independent cohort of cognitively normal older Caucasians adults (N = 122), top association findings were then used to create genetic scores to assess whether carrying more cognitive maintenance alleles was associated with greater GM volume in specific brain networks using voxel-based morphometry.ResultsThe most significant association was on chromosome 11 (rs7109806, P = 7.8 × 10(-8)) near RIC3. RIC3 modulates activity of α7 nicotinic acetylcholine receptors, which have been implicated in synaptic plasticity and beta-amyloid binding. In the neuroimaging cohort, carrying more cognitive maintenance alleles was associated with greater volume in the right executive control network (RECN; PFWE  = 0.01).ConclusionsThese findings suggest that there may be genetic loci that promote healthy cognitive aging and that they may do so by conferring robustness to GM in the RECN. Future work is required to validate top candidate genes such as RIC3 for involvement in cognitive maintenance

Introgressive Hybridization and the Evolution of Lake-Adapted Catostomid Fishes.

Hybridization has been identified as a significant factor in the evolution of plants as groups of interbreeding species retain their phenotypic integrity despite gene exchange among forms. Recent studies have identified similar interactions in animals; however, the role of hybridization in the evolution of animals has been contested. Here we examine patterns of gene flow among four species of catostomid fishes from the Klamath and Rogue rivers using molecular and morphological traits. Catostomus rimiculus from the Rogue and Klamath basins represent a monophyletic group for nuclear and morphological traits; however, the Klamath form shares mtDNA lineages with other Klamath Basin species (C. snyderi, Chasmistes brevirostris, Deltistes luxatus). Within other Klamath Basin taxa, D. luxatus was largely fixed for alternate nuclear alleles relative to C. rimiculus, while Ch. brevirostris and C. snyderi exhibited a mixture of these alleles. Deltistes luxatus was the only Klamath Basin species that exhibited consistent covariation of nuclear and mitochondrial traits and was the primary source of mismatched mtDNA in Ch. brevirostris and C. snyderi, suggesting asymmetrical introgression into the latter species. In Upper Klamath Lake, D. luxatus spawning was more likely to overlap spatially and temporally with C. snyderi and Ch. brevirostris than either of those two with each other. The latter two species could not be distinguished with any molecular markers but were morphologically diagnosable in Upper Klamath Lake, where they were largely spatially and temporally segregated during spawning. We examine parallel evolution and syngameon hypotheses and conclude that observed patterns are most easily explained by introgressive hybridization among Klamath Basin catostomids

Local free-fall temperature of a RN-AdS black hole

We use the global embedding Minkowski space (GEMS) geometries of a (3+1)-dimensional curved Reissner-Nordstr\"om(RN)-AdS black hole spacetime into a (5+2)-dimensional flat spacetime to define a proper local temperature, which remains finite at the event horizon, for freely falling observers outside a static black hole. Our extended results include the known limiting cases of the RN, Schwarzschild--AdS, and Schwarzschild black holes.Comment: 18 pages, 11 figures, version to appear in Int. J. Mod. Phys.

Critical behavior of Born Infeld AdS black holes in higher dimensions

Based on a canonical framework, we investigate the critical behavior of Born-Infeld AdS black holes in higher dimensions. As a special case, considering the appropriate limit, we also analyze the critical phenomena for Reissner Nordstrom AdS black holes. The critical points are marked by the divergences in the heat capacity at constant charge. The static critical exponents associated with various thermodynamic entities are computed and shown to satisfy the thermodynamic scaling laws. These scaling laws have also been found to be compatible with the static scaling hypothesis. Furthermore, we show that the values of these exponents are universal and do not depend on the spatial dimensionality of the AdS space. We also provide a suggestive way to calculate the critical exponents associated with the spatial correlation which satisfy the scaling laws of second kind.Comment: LaTex, 22 pages, 12 figures, minor modifications in text, To appear in Phys. Rev.

New Types of Thermodynamics from (1+1)(1+1)-Dimensional Black Holes

For normal thermodynamic systems superadditivity $\S$, homogeneity \H and concavity \C of the entropy hold, whereas for $(3+1)$-dimensional black holes the latter two properties are violated. We show that $(1+1)$-dimensional black holes exhibit qualitatively new types of thermodynamic behaviour, discussed here for the first time, in which \C always holds, \H is always violated and $\S$ may or may not be violated, depending of the magnitude of the black hole mass. Hence it is now seen that neither superadditivity nor concavity encapsulate the meaning of the second law in all situations.Comment: WATPHYS-TH93/05, Latex, 10 pgs. 1 figure (available on request), to appear in Class. Quant. Gra

Flat Information Geometries in Black Hole Thermodynamics

The Hessian of either the entropy or the energy function can be regarded as a metric on a Gibbs surface. For two parameter families of asymptotically flat black holes in arbitrary dimension one or the other of these metrics are flat, and the state space is a flat wedge. The mathematical reason for this is traced back to the scale invariance of the Einstein-Maxwell equations. The picture of state space that we obtain makes some properties such as the occurence of divergent specific heats transparent.Comment: 14 pages, one figure. Dedicated to Rafael Sorkin's birthda

The Fourth Law of Black Hole Thermodynamics

We show that black holes fulfill the scaling laws arising in critical transitions. In particular, we find that in the transition from negative to positive values the heat capacities $C_{JQ}$, $C_{\Omega Q}$ and $C_{J\Phi}$ give rise to critical exponents satisfying the scaling laws. The three transitions have the same critical exponents as predicted by the universality Hypothesis. We also briefly discuss the implications of this result with regards to the connections among gravitation, quantum mechanics and statistical physics.Comment: 19 pages (two figures), Plain Tex. Preprint KONS-RGKU-93-11. To appear in Nucl. Phys. B (1993

Synthetic studies on the organic compounds of beryllium

Not availabl

Quasi-Homogeneous Thermodynamics and Black Holes

We propose a generalized thermodynamics in which quasi-homogeneity of the thermodynamic potentials plays a fundamental role. This thermodynamic formalism arises from a generalization of the approach presented in paper [1], and it is based on the requirement that quasi-homogeneity is a non-trivial symmetry for the Pfaffian form $\delta Q_{rev}$. It is shown that quasi-homogeneous thermodynamics fits the thermodynamic features of at least some self-gravitating systems. We analyze how quasi-homogeneous thermodynamics is suggested by black hole thermodynamics. Then, some existing results involving self-gravitating systems are also shortly discussed in the light of this thermodynamic framework. The consequences of the lack of extensivity are also recalled. We show that generalized Gibbs-Duhem equations arise as a consequence of quasi-homogeneity of the thermodynamic potentials. An heuristic link between this generalized thermodynamic formalism and the thermodynamic limit is also discussed.Comment: 39 pages, uses RevteX. Published version (minor changes w.r.t. the original one

Thermodynamic curvature and black holes

I give a relatively broad survey of thermodynamic curvature $R$, one spanning results in fluids and solids, spin systems, and black hole thermodynamics. $R$ results from the thermodynamic information metric giving thermodynamic fluctuations. $R$ has a unique status in thermodynamics as being a geometric invariant, the same for any given thermodynamic state. In fluid and solid systems, the sign of $R$ indicates the character of microscopic interactions, repulsive or attractive. $|R|$ gives the average size of organized mesoscopic fluctuating structures. The broad generality of thermodynamic principles might lead one to believe the same for black hole thermodynamics. This paper explores this issue with a systematic tabulation of results in a number of cases.Comment: 27 pages, 10 figures, 7 tables, 78 references. Talk presented at the conference Breaking of Supersymmetry and Ultraviolet Divergences in extended Supergravity, in Frascati, Italy, March 27, 2013. v2 corrects some small problem