The Persistence of Segregation in Buffalo, New York

Debates about the causes of segregation continue to consider the role that own-race preferences have in understanding the persistence of racial residential segregation in American cities. In this paper, I offer an alternative to the own-race preference model. I argue that segregation of low-income Black households from Whites persists in Buffalo, New York, because the spatial rootedness of Blacks’ survival strategies leads households to choose housing in the central city, where their social networks and most Black households live. I illustrate this argument by exploring the multiple reasons for why a group of African American households, who were prompted to move through the settlement of a high-profile housing discrimination lawsuit, chose to relocate to neighborhoods in the central city in Buffalo. I adopt a context-sensitive perspective in making the argument and further argue that such approaches are ultimately useful in capturing the complex reasons that underlie the persistence of segregation

Politics of belonging in the construction of landscapes: place-making, boundary-drawing and exclusion

Issues of belonging, exclusion and the creation and maintenance of boundaries have surfaced in recent considerations of the production of space, yet the relevance of boundaries and belonging for understanding the construction of landscape has remained largely implicit. In this paper, I wish to explore more explicitly the connection of boundaries, belonging and landscapes by thinking about how landscapes become spatially bounded scenes that visually communicate what belongs and what does not. My focus is on understanding how landscapes are, in part, constructed through a territorialized politics of belonging-the discourses and practices that establish and maintain discursive and material boundaries that correspond to the imagined geographies of a polity and to the spaces that normatively embody the polity. To explore this relationship, I consider a controversy surrounding the operation of a slaughterhouse in Hugo, Minnesota, which was used extensively for Ua Dab-a Hmong tradition of ritual animal sacrifice. The discourses and practices surrounding efforts to remove the slaughterhouse from Hugo, on the one hand, and to have it remain in Hugo, on the other, offer a case through which to explore the politics of belonging and the boundaries that this creates in constructing landscapes

Low Resources in a High Stakes Game: Identifying Viable Rural Community Partners

Extension resources are shrinking, yet community leadership needs are great, and, the consequences of neglecting them are dire. It is difficult to respond to all the requests that are made of Extension faculty and even more difficult to decide which of the communities will benefit the most from programming. This article illuminates these issues by examining contributions from related research. First, a link is forged between community capital theory and community survival indicators. Next, 111 signs are provided that identify community viability. Finally, a guide is proposed for use in Extension to help determine where to concentrate scant resources

MHC Class II tetramers and the pursuit of antigen-specific T cells: define, deviate, delete.: MHC Class II tetramers

International audienceSelective expansion and activation of a very small number of antigen-specific CD4(+) T cells is a remarkable and essential property of the adaptive immune response. Antigen-specific T cells were until recently identified only indirectly by functional assays, such as antigen-induced cytokine secretion and proliferation. The advent of MHC Class II tetramers has added a pivotal tool to our research armamentarium, allowing the definition of allo- and autoimmune responses in deeper detail. Rare antigen-specific CD4(+) cells can now be selectively identified, isolated and characterized. The same tetramer reagents also provide a new mean of stimulating T cells, more closely reproducing the MHC-peptide/TCR interaction. This property allows the use of tetramers to direct T cells toward the more desirable outcome, that is, activation (in malignancies and infectious diseases) or Th2/T regulatory cell deviation, anergy and deletion (in autoimmune diseases). These experimental approaches hold promise for diagnostic, prognostic and therapeutic applications

The Massive and Distant Clusters of WISE Survey 2: Equatorial First Data Release

The Massive and Distant Clusters of WISE Survey 2 (MaDCoWS2) is a new survey designed as the successor of the original MaDCoWS survey. MaDCoWS2 improves upon its predecessor by using deeper optical and infrared data and a more powerful detection algorithm (PZWav). As input to the search, we use grz photometry from DECaLS in combination with W1 and W2 photometry from the CatWISE2020 catalog to derive the photometric redshifts with full redshift probability distribution functions for WISE-selected galaxies. Cluster candidates are then detected using the PZWav algorithm to find three-dimensional galaxy overdensities from the sky positions and photometric redshifts. This paper provides the first MaDCoWS2 data release, covering 1461 (1838 without masking) deg^2 centered on the Hyper-SuprimeCam Subaru Strategic Program equatorial fields. Within this region, we derive a catalog of 22,970 galaxy cluster candidates detected at S/N>5. These clusters span the redshift range 0.11.5. We compare MaDCoWS2 to six existing catalogs in the area. We rediscover 60%-92% of the clusters in these surveys at S/N>5. The medians of the absolute redshift offset are <0.02 relative to these surveys, while the standard deviations are less than 0.06. The median offsets between the detection position from MaDCoWS2 and other surveys are less than 0.25 Mpc. We quantify the relation between S/N and gas mass, total mass, luminosity, and richness from other surveys using a redshift-dependent power law relation. We find that the S/N-richness relation exhibits the lowest scatter.Comment: 27 pages, 7 figures. Typo corrected. Accepted for publication in Ap

Massive variceal bleeding secondary to splenic vein thrombosis successfully treated with splenic artery embolization: a case report

<p>Abstract</p> <p>Introduction</p> <p>Splenic vein thrombosis results in localized portal hypertension called sinistral portal hypertension, which may also lead to massive upper gastrointestinal bleeding. Symptomatic sinistral portal hypertension is usually best treated by splenectomy, but interventional radiological techniques are safe and effective alternatives in the management of a massive hemorrhage, particularly in cases that have a high surgical risk.</p> <p>Case presentation</p> <p>We describe a 23-year-old Greek man with acute massive gastric variceal bleeding caused by splenic vein thrombosis due to a missing von Leiden factor, which was successfully managed with splenic arterial embolization.</p> <p>Conclusions</p> <p>Interventional radiological techniques are attractive alternatives for patients with a high surgical risk or in cases when the immediate surgical excision of the spleen is technically difficult. Additionally, surgery is not always successful because of the presence of numerous portal collaterals and adhesion. Splenic artery embolization is now emerging as a safe and effective alternative to surgery in the management of massive hemorrhage from gastric varices due to splenic vein thrombosis, which often occurs in patients with hypercoagulability.</p

Functional inhibition related to structure of a highly potent insulin-specific CD8 T cell clone using altered peptide ligands

Insulin-reactive CD8 T cells are amongst the earliest islet-infiltrating CD8 T cells in NOD mice. Cloned insulin B15–23-reactive cells (designated G9C8), restricted by H-2Kd, are highly diabetogenic. We used altered peptide ligands (APL) substituted at TCR contact sites, positions (p)6 and 8, to investigate G9C8 T cell function and correlated this with structure. Cytotoxicity and IFN-γ production assays revealed that p6G and p8R could not be replaced by any naturally occurring amino acid without abrogating recognition and functional response by the G9C8 clone. When tested for antagonist activity with APL differing from the native peptide at either of these positions, the peptide variants, G6H and R8L showed the capacity to reduce the agonist response to the native peptide. The antagonist activity in cytotoxicity and IFN-γ production assays can be correlated with conformational changes induced by different structures of the MHC-peptide complexes, shown by molecular modeling. We conclude that p6 and p8 of the insulin B15–23 peptide are very important for TCR stimulation of this clone and no substitutions are tolerated at these positions in the peptide. This is important in considering the therapeutic use of peptides as APL that encompass both CD4 and CD8 epitopes of insulin

The principal neurons of the medial nucleus of the trapezoid body and NG2+ glial cells receive coordinated excitatory synaptic input

Glial cell processes are part of the synaptic structure and sense spillover of transmitter, while some glial cells can even receive direct synaptic input. Here, we report that a defined type of glial cell in the medial nucleus of the trapezoid body (MNTB) receives excitatory glutamatergic synaptic input from the calyx of Held (CoH). This giant glutamatergic terminal forms an axosomatic synapse with a single principal neuron located in the MNTB. The NG2 glia, as postsynaptic principal neurons, establish synapse-like structures with the CoH terminal. In contrast to the principal neurons, which are known to receive excitatory as well as inhibitory inputs, the NG2 glia receive mostly, if not exclusively, α-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid receptor–mediated evoked and spontaneous synaptic input. Simultaneous recordings from neurons and NG2 glia indicate that they partially receive synchronized spontaneous input. This shows that an NG2+ glial cell and a postsynaptic neuron share presynaptic terminals