What is Allium achaium Boiss. & Orph.? Disentangling the taxonomy of a Greek mountain species

Allium oreohellenicum Tzanoud., Tsakiri & Raus (Amaryllidaceae), endemic of the Greek mountains, is described and illustrated as a species new to science. Information regarding its cytology, geographical distribution and taxonomic relationships is also provided. Material belonging to A. oreohellenicum was formerly known/classified as A. achaium Boiss & Orph., a taxon described in 1882 based on a gathering by Orphanides from Mt Klokos (N Peloponnisos, Greece). A detailed study of the Orphanides gathering concerned revealed that it essentially belongs to A. frigidum Boiss. & Heldr., a taxon described 28 years earlier, and so the need for a new name

Is globalisation affecting the quality of life? A review of the literature

This review reveals that: significant changes arising from Globalization (G.) affect the quality of life; contradictory views due to a lack of consensus on the appropriate methodology and tools purposing to define and measure such an impact, and an enormous complexity of parameters characterising both issues, impede proper estimations of its nature; the appropriate strategies and policies -national or individual- towards G., can differentiate such an impact. The review also gives suggestions regarding future avenues of further research.peer-reviewe

Prothymosin a and a prothymosin α-derived peptide enhance TH1-type immune responses against defined HER-2/neu epitopes

Background: Active cancer immunotherapies are beginning to yield clinical benefit, especially those using peptide-pulsed dendritic cells (DCs). Different adjuvants, including Toll-like receptor (TLR) agonists, commonly co-administered to cancer patients as part of a DC-based vaccine, are being widely tested in the clinical setting. However, endogenous DCs in tumor-bearing individuals are often dysfunctional, suggesting that ex vivo educated DCs might be superior inducers of anti-tumor immune responses. We have previously shown that prothymosin alpha (proTα) and its immunoreactive decapeptide proTα(100–109) induce the maturation of human DCs in vitro. The aim of this study was to investigate whether proTα- or proTα(100–109)-matured DCs are functionally competent and to provide preliminary evidence for the mode of action of these agents. Results: Monocyte-derived DCs matured in vitro with proTα or proTα(100–109) express co-stimulatory molecules and secrete pro-inflammatory cytokines. ProTα- and proTα(100–109)-matured DCs pulsed with HER-2/neu peptides induce TH1-type immune responses, prime autologous naïve CD8-positive (+) T cells to lyse targets expressing the HER-2/neu epitopes and to express a polyfunctional profile, and stimulate CD4+ T cell proliferation in an HER-2/neu peptide-dependent manner. DC maturation induced by proTα and proTα(100–109) is likely mediated via TLR-4, as 25 shown by assessing TLR-4 surface expression and the levels of the intracellular adaptor molecules TIRAP, MyD88 and TRIF. Conclusions: Our results suggest that proTα and proTα(100–109) induce both the maturation and the T cell stimulatory capacity of DCs. Although further studies are needed, evidence for a possible proTα and proTα(100–109) interaction with TLR-4 is provided. The initial hypothesis that proTα and the proTα-derived immunoactive decapeptide act as “alarmins”, provides a rationale for their eventual use as adjuvants in DC-based anti-cancer immunotherapy

NoBody’s Perfect: Charm, Willfulness and Resistance

The purpose of this paper is to discuss the representations of disabled bodies on the basis of Niko von Glasow’s documentary film NoBody’s Perfect. Drawing on disability aesthetics (Siebers, 2006) and the notion of crip killjoys (Johnson & McRuer, 2014), it is argued that representations of crip killjoys and their unruly corporeality offer an aesthetic and political context in which the politics of disgust and resentment can be challenged (Hughes, 2015; Soldatic & Meekosha, 2012)

Effect of noise in principal component analysis with an application to ozone pollution

This thesis analyzes the effect of independent noise in principal components of k normally distributed random variables defined by a covariance matrix. We prove that the principal components as well as the canonical variate pairs determined from joint distribution of original sample affected by noise can be essentially different in comparison with those determined from the original sample. However when the differences between the eigenvalues of the original covariance matrix are sufficiently large compared to the level of the noise, the effect of noise in principal components and canonical variate pairs proved to be negligible. The theoretical results are supported by simulation study and examples. Moreover, we compare our results about the eigenvalues and eigenvectors in the two dimensional case with other models examined before. This theory can be applied in any field for the decomposition of the components in multivariate analysis