Future prospects for exploring present day anomalies in flavour physics measurements with Belle II and LHCb

A range of flavour physics observables show tensions with their corresponding Standard Model expectations: measurements of leptonic flavour-changing neutral current processes and ratios of semi-leptonic branching fractions involving different generations of leptons show deviations of the order of four standard deviations. If confirmed, either would be an intriguing sign of new physics. In this manuscript, we analyse the current experimental situation of such processes and for the first time estimate the combined impact of the future datasets of the Belle II and LHCb experiments on the present tensions with the Standard Model expectations by performing scans of the new physics contribution to the Wilson coefficients. In addition, the present day and future sensitivity of tree-level CKM parameters, which offer orthogonal tests of the Standard Model, are explored. Three benchmark points in time are chosen for a direct comparison of the estimated sensitivity between the experiments. A high complementarity between the future sensitivity achieved by the Belle II and LHCb experiments is observed due to their relative strengths and weaknesses. We estimate that all of the anomalies considered here will be either confirmed or ruled out by both experiments independently with very high significance by the end of data-taking at Belle II and the LHCb upgrade

Interprofessional, student-led intervention to improve insulin prescribing to patients in an Acute Surgical Receiving Unit

Our aim was to test the feasibility of interprofessional, workplace-based learning about improvement through a 4-week placement for one medical and two pharmacy final year students in an Acute Surgical Receiving Unit (ASRU). The target was insulin because this is a common, high-risk medicine in this ASRU and the intervention was medicines reconciliation. Baseline data were collected from 10 patients and used to construct a cause and effect diagram and a process map through feedback and discussions with staff. Hypoglycaemia occurred in four patients but hyperglycaemia occurred in eight patients, of whom six were placed on intravenous insulin infusion (IVII). We estimated that £2454 could be saved by preventing one patient from going on IVII. The students designed and tested a sticker to improve medicines reconciliation for insulin patients. An online form was created to capture clinician feedback on the layout and usability of the sticker. The intervention was associated with improvements in the reliability of medicines reconciliation. The students’ work contributed to a larger project to reduce the risk of hypoglycaemia in the ASRU. This proved beneficial in enabling the students to engage with the clinical team. Nonetheless, it was challenging for students from two Universities to get a shared understanding of improvement methods and work effectively with the clinical team. The students said that they learnt more about quality improvement in a working healthcare environment than they would ever learn in a classroom and they valued the opportunity to work with students from other healthcare backgrounds in practice. Despite the additional staff time required to support students from two Universities, both have supported continuation of this work

Foreword: Respectful, Equitable, and Supportive Postpartum Care

The postpartum period is a precious part of life: the health and wellbeing of at least 2 generations are at stake. Although the World Health Organization calls for a standard of care that promotes “positive” postpartum experiences with a “resourced and flexible health system”, these goals are largely aspirational. In her book, Baby Doctor, pediatrician Perri Klass writes about the moments immediately after birth. She describes how all eyes in the delivery room turn to the baby—except for the midwife or the obstetrician, who are the “only ones still paying attention to mom.” Anthropologist Shelia Kitzinger similarly wrote that “the spotlights are dimmed” for women after childbirth. In American medicine, we do not pay much attention to birthing people once the cord is clamped. The underlying notion of women as being worthy of focus only while they are vessels for new life is deeply harmful. It is as though the baby is the candy and the mother is the wrapper. After the candy is out, the wrapper is cast aside. This transactional thinking and treatment around childbirth is a tragedy, with short-term and long-term consequences

Which older people decline participation in a primary care trial of physical activity and why: insights from a mixed methods approach

This article is available through the Brunel Open Access Publishing Fund. Copyright 2014 Rogers et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.Background: Physical activity is of vital importance to older peoples’ health. Physical activity intervention studies with older people often have low recruitment, yet little is known about non-participants. Methods: Patients aged 60–74 years from three UK general practices were invited to participate in a nurse-supported pedometer-based walking intervention. Demographic characteristics of 298 participants and 690 non-participants were compared. Health status and physical activity of 298 participants and 183 non-participants who completed a survey were compared using age, sex adjusted odds ratios (OR) (95% confidence intervals). 15 non-participants were interviewed to explore perceived barriers to participation. Results: Recruitment was 30% (298/988). Participants were more likely than non-participants to be female (54% v 47%; p = 0.04) and to live in affluent postcodes (73% v 62% in top quintile; p < 0.001). Participants were more likely than non-participants who completed the survey to have an occupational pension OR 2.06 (1.35-3.13), a limiting longstanding illness OR 1.72 (1.05-2.79) and less likely to report being active OR 0.55 (0.33-0.93) or walking fast OR 0.56 (0.37-0.84). Interviewees supported general practice-based physical activity studies, particularly walking, but barriers to participation included: already sufficiently active, reluctance to walk alone or at night, physical symptoms, depression, time constraints, trial equipment and duration. Conclusion: Gender and deprivation differences suggest some selection bias. However, trial participants reported more health problems and lower activity than non-participants who completed the survey, suggesting appropriate trial selection in a general practice population. Non-participant interviewees indicated that shorter interventions, addressing physical symptoms and promoting confidence in pursuing physical activity, might increase trial recruitment and uptake of practice-based physical activity endeavours.The National Institute for Health Research (NIHR) under its Research for Patient Benefit Programme (Grant Reference Number PB-PG-0909-20055)

Doubly charmed B decays with the LHCb experiment

$CP$ violation is a necessary ingredient to create a matter-antimatter asymmetry. However, the amount of $CP$ violation incorporated in the Standard Model is orders of magnitude too small to explain the observed asymmetry. This thesis documents two studies of $CP$ violation with doubly charmed $B$ decays. Both were performed using Run I data collected by the LHCb experiment in $pp$ collisions at the LHC. This corresponds to 1.0 fb$^{-1}$ collected at a centre-of-mass energy of 7 TeV and 2.0 fb$^{-1}$ collected at a centre-of-mass energy of 8 TeV. The first analysis is a search for $B_c^+$ decays to two charm mesons, $B_c^+\to D^{(*)+}_{(s)}D^{(*)}$, where the second charm meson is either $D^0$ or $\overline{D}{}^0$, which are sensitive to the CKM angle \gamma. No evidence for signal is found and limits are set on twelve decay modes. The second analysis is the measurement of the $CP$ asymmetry in $B^+\to D^+_{(s)} \overline{D}{}^0$ decays. The results are \begin{align*} \mathcal{A}^{CP}(B^+\to D^+_{s} \overline{D}{}^0) &= (-0.4\pm 0.5\pm 0.5)\%,\\ \mathcal{A}^{CP}(B^+\to D^+ \overline{D}{}^0) &= (+2.3\pm 2.7\pm 0.4)\%, \end{align*} where the first uncertainty is statistical and the second systematic. This is the first measurement of $\mathcal{A}^{CP}(B^+\to D^+_{s} \overline{D}{}^0)$ and the most precise measurement of $\mathcal{A}^{CP}(B^+\to D^+\overline{D}{}^0)$ to date. The results are consistent with $CP$ symmetry.Funded by the Science and Technology Facilities Council (STFC)

Constraints on the χ_(c1) versus χ_(c2) polarizations in proton-proton collisions at √s = 8 TeV

The polarizations of promptly produced χ_(c1) and χ_(c2) mesons are studied using data collected by the CMS experiment at the LHC, in proton-proton collisions at √s=8  TeV. The χ_c states are reconstructed via their radiative decays χ_c → J/ψγ, with the photons being measured through conversions to e⁺e⁻, which allows the two states to be well resolved. The polarizations are measured in the helicity frame, through the analysis of the χ_(c2) to χ_(c1) yield ratio as a function of the polar or azimuthal angle of the positive muon emitted in the J/ψ → μ⁺μ⁻ decay, in three bins of J/ψ transverse momentum. While no differences are seen between the two states in terms of azimuthal decay angle distributions, they are observed to have significantly different polar anisotropies. The measurement favors a scenario where at least one of the two states is strongly polarized along the helicity quantization axis, in agreement with nonrelativistic quantum chromodynamics predictions. This is the first measurement of significantly polarized quarkonia produced at high transverse momentum

Birthing Parent Experiences of Postpartum at-Home Blood Pressure Monitoring Versus Office-Based Follow up After Diagnosis of Hypertensive Disorders of Pregnancy

Hypertensive disorders of pregnancy are a leading cause of pregnancy-related morbidity and mortality. The primary objective of this study was to compare the frequency of documentation of postpartum blood pressure through remote blood pressure monitoring with text-message delivered reminders versus office-based follow-up 7–10 days postpartum. The secondary objective was to examine barriers and facilitators of both care strategies from the perspectives of individuals who experienced a hypertensive disorder of pregnancy. We conducted a randomized controlled trial at a tertiary care academic medical center in the southeastern US with 100 postpartum individuals (50 per arm) from 2018 to 2019. Among 100 trial participants, blood pressure follow-up within 7–10 days postpartum was higher albeit not statistically significant between postpartum individuals randomized to the remote assessment intervention versus office-based standard care (absolute risk difference 18.0%, 95% CI −0.1 to 36.1%, p = 0.06). Patient-reported facilitators for remote blood pressure monitoring were maternal convenience, clarity of instructions, and reassurance from the health assessments. These positive aspects occurred alongside barriers, which included constraints due to newborn needs and the realities of daily postpartum life

Racial Disparities in Donor Human Milk Feedings: A Study Using Electronic Medical Records

Introduction: The aim of this study was to evaluate differences in the use of pasteurized donor human milk (PDHM) by maternal race-ethnicity during postpartum hospitalization using electronic medical records (EMRs). Materials and Methods: A retrospective cohort study of all live-born infants at our academic research institution from July 1, 2014, to June 30, 2016, was conducted. EMR data were used to determine whether each infant received mother's own milk (MOM), PDHM, or formula. These data were stratified based on whether the infant received treatment in the Neonatal Critical Care Center. Generalized estimating equation models were used to calculate the odds of receiving PDHM by maternal race-ethnicity, adjusting for gestational age, birth weight, insurance, preferred language, nulliparity, and mode of delivery. Results: Infant feeding data were available for 7097 infants, of whom 49% were fed only MOM during their postpartum hospitalization. Among the 15.9% of infants admitted to neonatal critical care, infants of non-Hispanic Black (odds ratio [OR] 0.47, 95% confidence interval [CI] 0.31-0.72), Hispanic (OR 0.65, 95% CI 0.36-1019), and Other (OR 0.63, 95% CI 0.32-1.26) mothers had lower rates of PDHM feedings than infants of non-Hispanic White mothers in the adjusted models. Among well infants, the use of PDHM was lower among non-Hispanic Black and Hispanic mothers (OR 0.25, 95% CI 0.18-0.36, and OR 0.38, 95% CI 0.26-0.56) compared with non-Hispanic White mothers. Conclusions: Inequities in exclusive human milk feeding and use of PDHM by maternal race-ethnicity were identified. Antiracist interventions are needed to promote equitable access to skilled lactation support and counseling for PDHM use

Measurement of the forward Z boson production cross-section in pp collisions at s=13\sqrt{s} = 13 TeV

A measurement of the production cross-section of Z bosons in pp collisions at $\sqrt{s} = 13$ TeV is presented using dimuon and dielectron final states in LHCb data. The cross-section is measured for leptons with pseudorapidities in the range $2.0 \eta 4.5$, transverse momenta $p_\text{T} 20$ GeV and dilepton invariant mass in the range $60 m(\ell\ell) 120$ GeV. The integrated cross-section from averaging the two final states is \begin{equation*}\sigma_{\text{Z}}^{\ell\ell} = 194.3 \pm 0.9 \pm 3.3 \pm 7.6\text{ pb,}\end{equation*} where the first uncertainty is statistical, the second is due to systematic effects, and the third is due to the luminosity determination. In addition, differential cross-sections are measured as functions of the Z boson rapidity, transverse momentum and the angular variable $\phi^*_\eta$