Menstrual disturbances in perimenopausal women: What's best?

It's best to start with nonsteroidal anti- inflammatory drugs (NSAIDs), which effectively reduce heavy menstrual bleeding (strength of recommendation [SOR]: B, systematic review of randomized clinical trials [RCTs]). Perimenopausal women with heavy bleeding not controlled by NSAIDs, or other forms of dysfunctional uterine bleeding, can benefit from continuous, combined hormonal therapy with estrogen and progestin; hormonal therapy with estrogen and a cyclical progestin; or a cyclical progestin alone (SOR: B, RCTs and a systematic review of RCTs). Intrauterine devices (IUDs) containing levonorgestrel also effectively reduce bleeding and may avoid surgical intervention (SOR: B, systematic review of RCTs)

Mapping the real space distributions of galaxies in SDSS DR7: I. Two Point Correlation Functions

Using a method to correct redshift space distortion (RSD) for individual galaxies, we mapped the real space distributions of galaxies in the Sloan Digital Sky Survey (SDSS) Data Release 7 (DR7). We use an ensemble of mock catalogs to demonstrate the reliability of our method. Here as the first paper in a series, we mainly focus on the two point correlation function (2PCF) of galaxies. Overall the 2PCF measured in the reconstructed real space for galaxies brighter than $^{0.1}{\rm M}_r-5\log h=-19.0$ agrees with the direct measurement to an accuracy better than the measurement error due to cosmic variance, if the reconstruction uses the correct cosmology. Applying the method to the SDSS DR7, we construct a real space version of the main galaxy catalog, which contains 396,068 galaxies in the North Galactic Cap with redshifts in the range $0.01 \leq z \leq 0.12$. The Sloan Great Wall, the largest known structure in the nearby Universe, is not as dominant an over-dense structure as appears to be in redshift space. We measure the 2PCFs in reconstructed real space for galaxies of different luminosities and colors. All of them show clear deviations from single power-law forms, and reveal clear transitions from 1-halo to 2-halo terms. A comparison with the corresponding 2PCFs in redshift space nicely demonstrates how RSDs boost the clustering power on large scales (by about $40-50\%$ at scales $\sim 10 h^{-1}{\rm {Mpc}}$) and suppress it on small scales (by about $70-80\%$ at a scale of $0.3 h^{-1}{\rm {Mpc}}$).Comment: 19 pages, 13 figure

Mapping the Real Space Distributions of Galaxies in SDSS DR7: II. Measuring the growth rate, clustering amplitude of matter and biases of galaxies at redshift 0.10.1

We extend the real-space mapping method developed in Shi et at. (2016) so that it can be applied to flux-limited galaxy samples. We use an ensemble of mock catalogs to demonstrate the reliability of this extension, showing that it allows for an accurate recovery of the real-space correlation functions and galaxy biases. We also demonstrate that, using an iterative method applied to intermediate-scale clustering data, we can obtain an unbiased estimate of the growth rate of structure $f\sigma_8$, which is related to the clustering amplitude of matter, to an accuracy of $\sim 10\%$. Applying this method to the Sloan Digital Sky Survey (SDSS) Data Release 7 (DR7), we construct a real-space galaxy catalog spanning the redshift range $0.01 \leq z \leq 0.2$, which contains 584,473 galaxies in the north Galactic cap (NGC). Using this data, we infer \fss at a median redshift $z=0.1$, which is consistent with the WMAP9 cosmology at the $1\sigma$ level. By combining this measurement with the real-space clustering of galaxies and with galaxy-galaxy weak lensing measurements for the same sets of galaxies, we are able to break the degeneracy between $f$, $\sigma_8$, and $b$. From the SDSS DR7 data alone, we obtain the following cosmological constraints at redshift $z=0.1$: $f=$$0.464^{+0.040}_{-0.040}$, $\sigma_8=0.769^{+0.121}_{-0.089}$, and $b=1.910^{+0.234}_{-0.268}$, $1.449^{+0.194}_{-0.196}$, $1.301^{+0.170}_{-0.177}$, and $1.196^{+0.159}_{-0.161}~$ for galaxies within different absolute magnitude bins $^{0.1}{\rm M}_r-5\log h=[-23,0, -22.0], [-22,0, -21.0], [-21.0, -20.0]$ and $[-20.0, -19.0]$, respectively

ELUCID IV: Galaxy Quenching and its Relation to Halo Mass, Environment, and Assembly Bias

We examine the quenched fraction of central and satellite galaxies as a function of galaxy stellar mass, halo mass, and the matter density of their large scale environment. Matter densities are inferred from our ELUCID simulation, a constrained simulation of local Universe sampled by SDSS, while halo masses and central/satellite classification are taken from the galaxy group catalog of Yang et al. The quenched fraction for the total population increases systematically with the three quantities. We find that the `environmental quenching efficiency', which quantifies the quenched fraction as function of halo mass, is independent of stellar mass. And this independence is the origin of the stellar mass-independence of density-based quenching efficiency, found in previous studies. Considering centrals and satellites separately, we find that the two populations follow similar correlations of quenching efficiency with halo mass and stellar mass, suggesting that they have experienced similar quenching processes in their host halo. We demonstrate that satellite quenching alone cannot account for the environmental quenching efficiency of the total galaxy population and the difference between the two populations found previously mainly arises from the fact that centrals and satellites of the same stellar mass reside, on average, in halos of different mass. After removing these halo-mass and stellar-mass effects, there remains a weak, but significant, residual dependence on environmental density, which is eliminated when halo assembly bias is taken into account. Our results therefore indicate that halo mass is the prime environmental parameter that regulates the quenching of both centrals and satellites.Comment: 21 pages, 16 figures, submitted to Ap

Talk the talk, walk the walk: Defining Critical Race Theory in research

Over the last decade there has been a noticeable growth in published works citing Critical Race Theory (CRT). This has led to a growth in interest in the UK of practical research projects utilising CRT as their framework. It is clear that research on 'race' is an emerging topic of study. What is less visible is a debate on how CRT is positioned in relation to methodic practice, substantive theory and epistemological underpinnings. The efficacy of categories of data gathering tools, both traditional and non-traditional is a discussion point here to explore the complexities underpinning decisions to advocate a CRT framework. Notwithstanding intersectional issues, a CRT methodology is recognisable by how philosophical, political and ethical questions are established and maintained in relation to racialised problematics. This paper examines these tensions in establishing CRT methodologies and explores some of the essential criteria for researchers to consider in utilising a CRT framework. © 2012 Copyright Taylor and Francis Group, LLC

A dynamic model of the eye nystagmus response to high magnetic fields

It was recently shown that high magnetic fields evoke nystagmus in human subjects with functioning vestibular systems. The proposed mechanism involves interaction between ionic currents in the endolymph of the vestibular labyrinth and the static magnetic field. This results in a Lorentz force that causes endolymph flow to deflect the cupulae of the semi-circular canals to evoke a vestibular-ocular reflex (VOR). This should be analogous to stimulation by angular acceleration or caloric irrigation. We made measurements of nystagmus slow-phase velocities in healthy adults experiencing variable magnetic field profiles of up to 7 Tesla while supine on a bed that could be moved smoothly into the bore of an MRI machine. The horizontal slow-phase velocity data were reliably modelled by a linear transfer function incorporating a low-pass term and a high-pass adaptation term. The adaptation time constant was estimated at 39.3 s from long-exposure trials. When constrained to this value, the low-pass time constant was estimated at 13.6 3.6 s (to 95% confidence) from both short and long exposure trials. This confidence interval overlaps with values obtained previously using angular acceleration and caloric stimulation. Hence it is compatible with endolymph flow causing a cupular deflection and therefore supports the hypothesis that the Lorentz force is a likely transduction mechanism of the magnetic-field evoked VOR

Morbidity and mortality in homeless individuals, prisoners, sex workers, and individuals with substance use disorders in high-income countries: a systematic review and meta-analysis.

BACKGROUND: Inclusion health focuses on people in extremely poor health due to poverty, marginalisation, and multimorbidity. We aimed to review morbidity and mortality data on four overlapping populations who experience considerable social exclusion: homeless populations, individuals with substance use disorders, sex workers, and imprisoned individuals. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, and the Cochrane Library for studies published between Jan 1, 2005, and Oct 1, 2015. We included only systematic reviews, meta-analyses, interventional studies, and observational studies that had morbidity and mortality outcomes, were published in English, from high-income countries, and were done in populations with a history of homelessness, imprisonment, sex work, or substance use disorder (excluding cannabis and alcohol use). Studies with only perinatal outcomes and studies of individuals with a specific health condition or those recruited from intensive care or high dependency hospital units were excluded. We screened studies using systematic review software and extracted data from published reports. Primary outcomes were measures of morbidity (prevalence or incidence) and mortality (standardised mortality ratios [SMRs] and mortality rates). Summary estimates were calculated using a random effects model. FINDINGS: Our search identified 7946 articles, of which 337 studies were included for analysis. All-cause standardised mortality ratios were significantly increased in 91 (99%) of 92 extracted datapoints and were 11·86 (95% CI 10·42-13·30; I2=94·1%) in female individuals and 7·88 (7·03-8·74; I2=99·1%) in men. Summary SMR estimates for the International Classification of Diseases disease categories with two or more included datapoints were highest for deaths due to injury, poisoning, and other external causes, in both men (7·89; 95% CI 6·40-9·37; I2=98·1%) and women (18·72; 13·73-23·71; I2=91·5%). Disease prevalence was consistently raised across the following categories: infections (eg, highest reported was 90% for hepatitis C, 67 [65%] of 103 individuals for hepatitis B, and 133 [51%] of 263 individuals for latent tuberculosis infection), mental health (eg, highest reported was 9 [4%] of 227 individuals for schizophrenia), cardiovascular conditions (eg, highest reported was 32 [13%] of 247 individuals for coronary heart disease), and respiratory conditions (eg, highest reported was 9 [26%] of 35 individuals for asthma). INTERPRETATION: Our study shows that homeless populations, individuals with substance use disorders, sex workers, and imprisoned individuals experience extreme health inequities across a wide range of health conditions, with the relative effect of exclusion being greater in female individuals than male individuals. The high heterogeneity between studies should be explored further using improved data collection in population subgroups. The extreme health inequity identified demands intensive cross-sectoral policy and service action to prevent exclusion and improve health outcomes in individuals who are already marginalised. FUNDING: Wellcome Trust, National Institute for Health Research, NHS England, NHS Research Scotland Scottish Senior Clinical Fellowship, Medical Research Council, Chief Scientist Office, and the Central and North West London NHS Trust

Enabling the classroom and the curriculum: higher education, literary studies and disability

In this article the tripartite model of disability is applied to the lived experience of twenty-first-century higher education. The tripartite model facilitates a complex understanding of disability that recognises assumptions and discrimination but not at the cost of valued identity. This being so, not only the normative positivisms and non-normative negativisms but also the non-normative positivisms of the classroom and the curriculum are explored. Inclusion is taken as the starting point and the argument progresses to a profound and innovational appreciation of disability. The problem addressed is that inclusion, as shown in The Biopolitics of Disability, constitutes little more than inclusion-ism until disability is recognised in the context of alternative lives and values that neither enforce nor reify normalcy. Informed by this understanding, the article adopts the disciplinary example of literary studies and refers to Brian Friel’s Molly Sweeney as a primary text. The conclusion is that, despite passive and active resistance, disability enters higher education in many ways, most of which are beneficial to students and educators alike