Supersensitive PSA-Monitored neoadjuvant hormone treatment of clinically localized prostate cancer: Effects on positive margins, tumor detection and epithelial cells in bone marrow

Objective: The present study was done to investigate the effects of supersensitive PSA-controlled inductive treatment on positive margins, detection of tumor and epithelial cells in bone marrow of 101 patients with untreated and clinically localized prostatic carcinoma (cT1-3N0M0). Methods: Hormonal treatment was given until PSA (DPD Immulite(R) third-generation assay) reached 0.3 ng/ml in only 1 case. Of the 101 patients, 82 had a measurable hypoic lesion on initial transrectal ultrasound. 84% of these became smaller, 7.5% remained unchanged and 8.5% increased. Of the 101 prostatectomy specimens, 20 (20%) were margin-positive. The incidence of affected margins was relatively high (35% from 55 patients) with cT3 tumors, but almost negligible (2% from 46 patients) in cT1-2 tumor. Our pathologists, despite their great experience in evaluating hormonally treated prostates (>500 cases) and using immunohistochemical staining, were unable to detect carcinoma in 15 (15%) specimens. Whereas only 2 (4%) of the 55 cT3 specimens were without detectable tumor, this incidence rised to 28% (13 of 46 prostates) in patients with cT1-2 tumors. Of the initial 29 patients with epithelial cells in bone marrow, only 4 (14%) remained positive after controlled induction and all of them had fewer cells than before. Conclusion: Endocrine induction controlled by a supersensitive PSA assay and continued until reaching PSA nadir is highly effective in clearing surgical margins and eliminating tumor cells from bone marrow. It seems to be clearly superior to the conventional 3 months of pretreatment at least in cT1-2 tumors in respect to surgical margins and detectability of tumor in the resected prostate. A definitive statement about the value of endocrine induction can only be given by prospective randomized studies, with optimal drugs, doses and treatment time. But the conventional 3 months of pretreatment are far from exploiting the possibilities of this therapeutic option

Light Spectrum and Decay Constants in Full QCD with Wilson Fermions

We present results from an analysis of the light spectrum and the decay constants f_{\pi} and f_V^{-1} in Full QCD with n_f=2 Wilson fermions at a coupling of beta=5.6 on a 16^3x32 lattice.Comment: 3 pages, LaTeX with 4 eps figures, Talk presented at LATTICE96(spectrum

Light Quark Physics with Dynamical Wilson Fermions

We present results for spectroscopy, quark masses and decay constants obtained from SESAM's and TkL's large statistics simulations of QCD with two dynamical Wilson fermions.Comment: 3 pages; to appear in the proceedings of Lat.'9

Light Quark Masses with Dynamical Wilson Fermions

We determine the masses of the light and the strange quarks in the $\bar{MS}$-scheme using our high-statistics lattice simulation of QCD with dynamical Wilson fermions. For the light quark mass we find $m^{light}_{\bar{MS}}(2 GeV) = 2.7(2) MeV$, which is lower than in quenched simulations. For the strange quark, in a sea of two dynamical light quarks, we obtain $m^{strange}_{\bar{MS}}(2 GeV) = 140(20) MeV$.Comment: 10 pages (latex file, uses epsf-style

Towards the glueball spectrum of full QCD

We present first results on masses of the scalar and tensor glueballs as well as of the torelon from simulations of QCD with two light flavours of Wilson fermions. The gauge configurations of extent 16^3*32 at beta = 5.6 and kappa = 0.156, 0.157 and 0.1575 have been generated as part of the SESAM collaboration programme. The present lattice resolutions correspond to 1/a = 2.0-2.3 GeV and ratios m(pi)/m(rho) = 0.83, 0.76 and 0.71, respectively. Studies on larger lattice volumes and closer to the chiral limit are in progress.Comment: 4 pages, LaTeX, espcrc2 and epsf styles required, 4 epsf figures, poster presented by G. Bali at Lattice '9

Critical Dynamics of the Hybrid Monte Carlo Algorithm

We investigate the critical dynamics of the Hybrid Monte Carlo algorithm approaching the chiral limit of standard Wilson fermions. Our observations are based on time series of lengths O(5000) for a variety of observables. The lattice sizes are 16^3 x 32 and 24^3 x 40. We work at beta=5.6, and kappa=0.156, 0.157, 0.1575, 0.158, with 0.83 > m_pi/m_rho > 0.55. We find surprisingly small integrated autocorrelation times for local and extended observables. The dynamical critical exponent $z$ of the exponential autocorrelation time is compatible with 2. We estimate the total computational effort to scale between V^2 and V^2.25 towards the chiral limit.Comment: 3 pages, Latex with espcrc2.sty and postscript figures, Talk given at Lattice 9

First Evidence of NfN_f-Dependence in the QCD Interquark Potential

We present a lattice calculation of the interquark potential between static quarks in a ``full'' QCD simulation with 2 flavours of dynamical Wilson-quarks at three intermediate sea-quark masses. We work at $\beta = 5.6$ on lattice size of $16^3 \times 32$ with 100 configurations per sea-quark mass. We compare the full QCD potential with its quenched counterpart at equal lattice spacing, $a^{-1} \simeq 2.0$ GeV, which is at the onset of the quenched scaling regime. We find that the full QCD potential lies consistently below that of quenched QCD. We see no evidence for string-breaking effects on these lattice volumes, $V \simeq (1.5\,\,{\rm fm})^3$.Comment: 9 pages (1 tex file epsf-style + 6 ps-figures

Glueballs and string breaking from full QCD

We present results on the static potential, and torelon and glueball masses from simulations of QCD with two flavours of dynamical Wilson fermions on $16^3\times 32$ and $24^3\times 40$ lattices at $\beta=5.6$.Comment: Talk presented by Gunnar Bali at International Symposium on Lattice Field Theories (Lattice 97), Edinburgh, July 1997, 3 pages LaTeX (epscrc2.sty) with 4 eps figure

Scanning the Topological Sectors of the QCD Vacuum with Hybrid Monte Carlo

We address a long standing issue and determine the decorrelation efficiency of the Hybrid Monte Carlo algorithm (HMC), for full QCD with Wilson fermions, with respect to vacuum topology. On the basis of five state-of-the art QCD vacuum field ensembles (with 3000 to 5000 trajectories each and m_pi/m_rho-ratios in the regime >0.56, for two sea quark flavours) we are able to establish, for the first time, that HMC provides sufficient tunneling between the different topological sectors of QCD. This will have an important bearing on the prospect to determine, by lattice techniques, the topological susceptibility of the vacuum, and topology sensitive quantities like the spin content of the proton, or the eta' mass.Comment: 5 pages, 4 eps-figure

SESAM and TXL Results for Wilson Action--A Status Report

Results from two studies of full QCD with two flavours of dynamical Wilson fermions are presented. At beta=5.6, the region 0.83 > m_pi/m_rho > 0.56 at m_pia > 0.23 L^{-1} is explored. The SESAM collaboration has generated ensembles of about 200 statistically independent configurations on a 16^3 x 32-lattice at three different kappa-values and is entering the final phase of data analysis. The TXL simulation on a 24^3 x 40-lattice at two kappa-values has reached half statistics and data analysis has started recently, hence most results presented here are preliminary. The focus of this report is fourfold: we demonstrate that algorithmic improvements like fast Krylov solvers and parallel preconditioning recently introduced can be put into practise in full QCD simulations, we present encouraging observations as to the critical dynamics of the Hybrid Monte Carlo algorithm in the approach to the chiral limit, we mention signal improvements of noisy estimator techniques for disconnected diagrams to the pi-N sigma term, and we report on SESAM's results for light hadron spectrum, light quark masses, and heavy quarkonia.Comment: 24 pages, tex + postscript figures, to appear in Proceedings of Int. Workshop "Lattice QCD on Parallel Computers", University of Tsukuba, Japa