Changes in serum lactate to aerobic exercise among amateur athletes and non-athletes

Lactate is an end product of glucose metabolism that is usually produced in a larger quantity during exercise. This increase in production during exercise has been understood to be the reason for fatigue. The aim of this study is to determine the responses of serum lactate to aerobic exercise among amateur athletes and non-athletes. 48 consenting males (24 amateur athletes and 24 non-athletes) participated in this comparative quasi-experimental design. Subjects cycled on a bicycle ergometer to attain moderate intensity exercise target heart rate (MIETHR) and maintained the MIETHR till exhaustion (15 on Borgs scale or volitional exertion) while the serum lactate was measured at intervals. Data were analyzed with descriptive statistics and inferential statistics of Analysis of variance (ANOVA). Alpha level was set at p < 0.05. The mean age of the participants was 26.08±2.28 and 28.13±1.51 for the athletes and non-athletes respectively. There was a significant difference p=0.001 Training induced adaptations include a lower serum lactate level, a point that should be noted in studying of metabolic adaptations.Keywords: Lactate, Athletes, Exercise, Response, Fitnes

Effectiveness of heparin versus 0.9% saline solution in maintaining the permeability of central venous catheters: a systematic review

Abstract OBJECTIVE Determining which is the most effective solution (heparin flush compared to 0.9% saline flush) for reducing the risk of occlusions in central venous catheters (CVC) in adults. METHOD The systematic review followed the principles proposed by the Cochrane Handbook; critical analysis, extraction and synthesis of data were performed by two independent researchers; statistical analysis was performed using the RevMan program 5.2.8. RESULTS Eight randomized controlled trials and one cohort study were included and the results of the meta-analysis showed no difference (RR=0.68, 95% CI=0.41-1.10; p=0.12). Analysis by subgroups showed that there was no difference in fully deployed CVC (RR=1.09, CI 95%=0.53-2.22;p=0.82); Multi-Lumen CVC showed beneficial effects in the heparin group (RR=0.53, CI 95%=0.29-0.95; p=0.03); in Double-Lumen CVC for hemodialysis (RR=1.18, CI 95%=0.08-17.82;p=0.90) and Peripherally inserted CVC (RR=0.14, CI 95%=0.01-2.60; p=0.19) also showed no difference. CONCLUSION Saline solution is sufficient for maintaining patency of the central venous catheter, preventing the risks associated with heparin administration