Civil Society Elites: A Research Agenda

This editorial introduces the thematic issue on ‘civil society elites,’ a topic that has been neglected in elite research as well as civil society studies. It elaborates on the concept of ‘civil society elites’ and explains why this is an important emerging research field. By highlighting different methodological approaches and key findings in the contributions to the thematic issue, this article aims at formulating an agenda for future research in this field

«Облік і аудит товарів та їх реалізації на прикладі ТОВ Оптімус Агро Трейд)»

&lt;b&gt;&lt;i&gt;Background/Aims:&lt;/i&gt;&lt;/b&gt; Treatment strategies for abnormal mineral metabolism in chronic kidney disease are largely based on achieving target ranges of biomarkers that vary considerably over time, yet determinants of their variability are poorly defined. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; Observational study including 162 patients of three dialysis cohorts (peritoneal dialysis, n = 78; hemodialysis, n = 49; hemodiafiltration, n = 35). Clinical and biochemical determinants of parathyroid hormone (PTH) and fibroblast growth factor-23 (FGF23) variability were analyzed in the peritoneal dialysis cohort. All cohorts were used for comparison of PTH and FGF23 intra-subject variability (intra-class correlation), and their intra-subject variability in different modes of dialysis was explored. &lt;b&gt;&lt;i&gt;Results: &lt;/i&gt;&lt;/b&gt;High PTH variability was independently associated with lower 25-hydroxyvitamin D concentration and factors of lipid and glucose metabolism, whereas high FGF23 variability was mainly associated with lower baseline serum phosphorous. These results were consistent in multivariate and sensitivity analyses. The intra-subject variability of FGF23 was lower than for PTH irrespective of dialysis mode. &lt;b&gt;&lt;i&gt;Conclusions:&lt;/i&gt;&lt;/b&gt; Baseline vitamin D status and serum phosphorous are independent determinants of the longitudinal variation in PTH and FGF23, respectively. The clinical utility of FGF23 measurement remains unknown, yet it appears favorable based on its greater temporal stability than PTH in dialysis patients.</jats:p

State-society relations in contemporary Russia: New forms of political and social contention

Much existing analysis of Russian state–society relations focuses on public, active forms of contention such as the “opposition” and protest movements. There is need for a more holistic perspective which adds study of a range of overt, “co-opted”, and hidden forms of interaction to this focus on public contention. A theoretical and empirical basis for understanding state–society relations in today's Russia involves broadening the concept of “contentious politics” to include models of “consentful” as well as “dissentful” contention. A diffused model of contentious politics can situate claim-making along the axes of consentful and dissentful motivations, and compliant and contentious behaviours

DNA building blocks: keeping control of manufacture

Ribonucleotide reductase (RNR) is the only source for de novo production of the four deoxyribonucleoside triphosphate (dNTP) building blocks needed for DNA synthesis and repair. It is crucial that these dNTP pools are carefully balanced, since mutation rates increase when dNTP levels are either unbalanced or elevated. RNR is the major player in this homeostasis, and with its four different substrates, four different allosteric effectors and two different effector binding sites, it has one of the most sophisticated allosteric regulations known today. In the past few years, the structures of RNRs from several bacteria, yeast and man have been determined in the presence of allosteric effectors and substrates, revealing new information about the mechanisms behind the allosteric regulation. A common theme for all studied RNRs is a flexible loop that mediates modulatory effects from the allosteric specificity site (s-site) to the catalytic site for discrimination between the four substrates. Much less is known about the allosteric activity site (a-site), which functions as an on-off switch for the enzyme's overall activity by binding ATP (activator) or dATP (inhibitor). The two nucleotides induce formation of different enzyme oligomers, and a recent structure of a dATP-inhibited α6β2 complex from yeast suggested how its subunits interacted non-productively. Interestingly, the oligomers formed and the details of their allosteric regulation differ between eukaryotes and Escherichia coli Nevertheless, these differences serve a common purpose in an essential enzyme whose allosteric regulation might date back to the era when the molecular mechanisms behind the central dogma evolved

National democratization theory and global governance: Civil society and the liberalization of the Asian Development Bank

Contributing to a growing literature on democracy beyond the nation-state, this article draws on aspects of national democratization theory in order to analyse empirical processes of democracy. By combining insights from transition theory and the theory of political opportunity structures, the article examines the case of the Asian Development Bank (ADB). While the ADB for a long time has been described as a closed, unresponsive and unaccountable international organization, a recent evaluation praised the Bank for its good practices concerning transparency, participation and accountability. The article uses the analytical framework to highlight the interaction between hard-liners and soft-liners within the ADB and explores the role of different transnational civil society actors in the processes that seem to have strengthened the democratic credentials of the ADB. While finding significant divisions within the ADB as well as amongst civil society actors targeting the Bank, overall the article argues that transnational civil society actors, interacting with soft-liners within the ADB, have contributed to the implementation of reforms, which in turn create political opportunities for further civil society activism. The reform processes, however, are best described as processes of liberalization – rather than democratization

Transnational Democratic Diffusion and Indonesian Democracy Discourses

There is a wide variety of ideas on democracy and democratization represented among the Indonesian democratic opposition. What is most striking is the importance of Islam as a motivation and inspiration for demands for democracy. Islam, like any other religion, can promote democratic as well as antidemocratic ideas. It is clear that the struggle for democracy in Indonesia is mainly motivated and driven by the domestic situation and not at all manipulated from abroad, as is sometimes argued by the government. However, external influences seemed to be an important inspiration showing that change is possible. This encouraging effect is more important than the diffusion of specific ideas on democracy and democratization