Sustainable economic growth within environmental limits. volume 1: guidance for the east midlands

LUC and GHK have developed a tool for setting environmental limits that local communities and other stakeholders can use. The three-step approach is based on the participation of the local community and other interested stakeholders, such as statutory agencies and businesses. It enables them to debate the use of important national, regional and local environmental assets, and the potential economic and social implications of setting environmental limits. The approach also provides a tool that can usefully support and inform other assessment requirements, such as Sustainability Appraisal/Strategic Environmental Assessment, Habitats Regulations Assessment and Equality Impact Assessment/Health Impact Assessment

Sustainable economic growth within environmental limits hypothetical case study: 'limitville'

A new approach to delivering ‘sustainable economic growth within environmental limits’ has been developed for the East Midlands. The approach is described in detail in a guidance document prepared by Land Use Consultants and GHK Consulting for emda and partners. The ‘Limitville’ case study was developed to test and illustrate the new approach

Satellite remote sensing for ice sheet research

Potential research applications of satellite data over the terrestrial ice sheets of Greenland and Antarctica are assessed and actions required to ensure acquisition of relevant data and appropriate processing to a form suitable for research purposes are recommended. Relevant data include high-resolution visible and SAR imagery, infrared, passive-microwave and scatterometer measurements, and surface topography information from laser and radar altimeters

Tanam Lingkar Berjajar Untuk Meningkatkan Populasi Dan Produksi Pada Tanaman Jagung Manis (Zea Mays - Saccharata)

Produksi jagung manis dapat ditingkatkan melalui perbaikan genetik dan pengaturan ruang (tumbuh melalui pengaturan populasi tanaman dan ketersediaan unsurhara dan air yang cukup). Tujuan dari penelitian adalah untuk mengetahui pengaruh tanam lingkar berjajar terhadap populasi dan produksi tanaman jagung manis. Penelitian dilaksanakan pada bulan Juli – Oktober 2017 di Ponorogo, Jawa Timur dengan ketinggian 140 m dpl dan jenis tanah adalah grumosol. Penelitian ini menggunakan Rancangan Acak Kelompok (RAK) yang terdiri dari empat perlakuan dengan enam kali ulangan. Faktor yang diteliti adalah metode tanam, meliputi : tanam tunggal dengan jarak tanam 20x60 cm; tanam lingkar berjajar dengan jarak tanam 50x70 cm; tanam lingkar berjajar dengan jarak tanam 60x80 cm; tanam lingkar berjajar dengan jarak tanam 70x80 cm. Hasil penelitian menunjukkan bahwa : 1). Perlakuan tanam lingkar berjajar meningkatkan populasi tanaman jagung manis sebesar 239 – 274 % dari tanam tunggal. 2). Tanam Lingkar berjajar dengan jarak tanam 70x80 cm dengan jumlah populasi 75.382 per Ha menghasilkan berat tongkol segar sebesar 26,06 ton/Ha

Detecting a signal in the noise : Monitoring the global spread of novel psychoactive substances using media and other open source information

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. Date of Acceptance: 16/02/2015To determine the feasibility and utility of using media reports and other open-source information collected by the Global Public Health Intelligence Network (GPHIN), an event-based surveillance system operated by the Public Health Agency of Canada, to rapidly detect clusters of adverse drug events associated with ‘novel psychoactive substances’ (NPS) at the international levelPeer reviewedFinal Published versio

Diazepam, alcohol use and violence among male young offenders: 'the devil's mixture’

Citation for published version (APA): Forsyth, A., Khan, F., & McKinlay, W. (2011). Diazepam, alcohol use and violence among male young offenders: 'the devil's mixture’. Drugs: Education, Prevention and Policy, 18(6), 468-476. 10.3109/09687637.2011.563762 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. • Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the ResearchOnline@GCU portal Take down polic

Standard PK/PD concepts can be applied to determine a dosage regimen for a macrolide: the case of tulathromycin in the calf

The pharmacokinetic (PK) profile of tulathromycin, administered to calves subcutaneously at the dosage of 2.5 mg/kg, was established in serum, inflamed (exudate), and noninflamed (transudate) fluids in a tissue cage model. The PK profile of tulathromycin was also established in pneumonic calves. For Mannheimia haemolytica and Pasteurella multocida, tulathromycin minimum inhibitory concentrations (MIC) were approximately 50 times lower in calf serum than in Mueller–Hinton broth. The breakpoint value of the PK/pharmacodynamic (PD) index (AUC(0–24 h)/MIC) to achieve a bactericidal effect was estimated from in vitro time‐kill studies to be approximately 24 h for M. haemolytica and P. multocida. A population model was developed from healthy and pneumonic calves and, using Monte Carlo simulations, PK/PD cutoffs required for the development of antimicrobial susceptibility testing (AST) were determined. The population distributions of tulathromycin doses were established by Monte Carlo computation (MCC). The computation predicted a target attainment rate (TAR) for a tulathromycin dosage of 2.5 mg/kg of 66% for M. haemolytica and 87% for P. multocida. The findings indicate that free tulathromycin concentrations in serum suffice to explain the efficacy of single‐dose tulathromycin in clinical use, and that a dosage regimen can be computed for tulathromycin using classical PK/PD concepts

Health and Safety Executive

flammable gas detector

The regulatory cliff edge between contraception and abortion: the legal and moral significance of implantation

In regulating the voluntary interruption of pregnancy, English law has accorded particular significance to two biological events. First, ‘viability’, the moment when a fetus is said to acquire the capacity for independent life, plays an important role in grounding restrictions on access to legal abortion later in pregnancy. Second, equally significantly but far less frequently discussed, ‘implantation’ marks the point in pregnancy from which abortion laws apply. This paper focuses on this earlier biological event. It suggests that an unquestioning reliance on implantation as marking an appropriate moment of transition between two radically different legal frameworks is deeply problematic and is rendered still less sustainable in the light of the development of new technologies that potentially operate shortly after the moment of implantation