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Notícia relativa a la imatge que tenen els hispanoamericans dels diferents nacionalismes que hi ha a Espanya

Targeting c-Met Receptor Overcomes TRAIL-Resistance in Brain Tumors

Tumor necrosis factor related apoptosis-inducing ligand (TRAIL) induced apoptosis specifically in tumor cells. However, with approximately half of all known tumor lines being resistant to TRAIL, the identification of TRAIL sensitizers and their mechanism of action become critical to broadly use TRAIL as a therapeutic agent. In this study, we explored whether c-Met protein contributes to TRAIL sensitivity. We found a direct correlation between the c-Met expression level and TRAIL resistance. We show that the knock down c-Met protein, but not inhibition, sensitized brain tumor cells to TRAIL-mediated apoptosis by interrupting the interaction between c-Met and TRAIL cognate death receptor (DR) 5. This interruption greatly induces the formation of death-inducing signaling complex (DISC) and subsequent downstream apoptosis signaling. Using intracranially implanted brain tumor cells and stem cell (SC) lines engineered with different combinations of fluorescent and bioluminescent proteins, we show that SC expressing a potent and secretable TRAIL (S-TRAIL) have a significant anti-tumor effect in mice bearing c-Met knock down of TRAIL-resistant brain tumors. To our best knowledge, this is the first study that demonstrates c-Met contributes to TRAIL sensitivity of brain tumor cells and has implications for developing effective therapies for brain tumor patients

Evaluación tecno-económica para cambio de equipo Velatorio Cristo Rey

72 p.Nombre de la obra: Velatorio “Cristo Rey” Mandante: Padre Andrés Lacalle Andrés Ubicación: San Nicolás, VIII región del Bío-Bío Coordenadas: 36°29’58"S y 72°12’45"W Proveniencia de los dineros: Dineros Públicos: Dinero Privados: $2.046.375.- Dineros Municipales:$ 100.000.- Dineros por Donaciones: $8.902.410.- Dineros Propios: Costo Total de la Obra:$ 11.048.785.- Costo Real al Mandante: $2.046.375. Desglosé de Dineros Materiales Comprados: Maderas:$ 2.823.785.- Insumos Generales: $1.625.000.- Donaciones en Dinero:$ 2.402.410.- Donaciones en Materiales (Valores equivalentes en dinero.) Maderas: $ 1.000.000.

Counterexample-Guided Polynomial Loop Invariant Generation by Lagrange Interpolation

We apply multivariate Lagrange interpolation to synthesize polynomial quantitative loop invariants for probabilistic programs. We reduce the computation of an quantitative loop invariant to solving constraints over program variables and unknown coefficients. Lagrange interpolation allows us to find constraints with less unknown coefficients. Counterexample-guided refinement furthermore generates linear constraints that pinpoint the desired quantitative invariants. We evaluate our technique by several case studies with polynomial quantitative loop invariants in the experiments

La relación ser - deber ser en el iusnaturalismo

10 p.El propósito de este trabajo es aplicar los conceptos del ser y del deber ser a un caso real y debatido recientemente, para lograr este objetivo el escrito se dividirá en cuatro partes. Por lo tanto, en la primera parte, se analizará La ley de HumeI. Ley de Hume II. Primer concepto A. Primer concepto al caso aplicado III. Segundo concepto A. Segundo concepto aplicado al caso IV. Conclusión Referencia

Versorgungsqualität der Sekundärprävention von jungen Patienten mit Koronarer Herzerkrankung

von Stephanie Usla