Atherosclerotic Parameter Level Differences in Mongolian People Compared to Japanese People: A Brief Review of the Literature

Objectives: In Mongolia, non-communicable disease caused morbidity and mortality related to lifestyle and metabolic diseases are increasing year after year. This review discusses the results of comparative studies related to lifestyle risk factors and the atherosclerotic parameters body mass index, glucose, insulin, and lipid level of Mongolian and Japanese people, as these are the known factors involved in metabolic and cardiovascular diseases. Methods: Academic literature was searched using electronic academic databases and handsearching reference lists for articles published in English and Mongolian on the topic. Results: The studies revealed that in comparison to Japanese subjects, a higher percentage of Mongolians smoked, and Mongolians had higher body mass index, heart rate, blood pressure, and insulin even though levels of serum total cholesterol and glucose were not different. Conclusion: The studies suggest that Mongolian people have higher risk of metabolic syndrome, which is a known main cause of CVDs, compared to Japanese people. On the other hand, climate, genetic and lifestyle differences might also increase non-communicable diseases in the Mongolian people

Dehydrocostus Lactone Down - regulates Lipopolysaccharide-induced SAA3 gene activation in the Microglia.

Running Title: DDL inhibits the LPS-induced SAA3 gene expression in microgliaObjective: Research on the mechanism of Dehydrocostus lactone (DDL) in microglial cells of the brain needs to be improved, despite its reported anti-inflammatory, anticancer, and anti-proliferation properties as a natural product of Eerdun Wurile The precise functions of the Serum amyloid A (SAA) genes are not yet defined. However, these genes are suggested to possess antibacterial properties and can attract monocytes and neutrophils. On the other hand, SAA genes can also induce inflammatory cytokines and metalloproteinases in smooth muscle cells and macrophages, thus promoting inflammation. This study aimed to investigate the impact of DDL on SAA3 gene expression in microglial cells stimulated by LPS.Methods: The anti-inflammatory effects of DDL were studied using LPS-stimulated murine BV2 microglia. BV2 was cultured in DMEM, and then 4µM DDL was added. Then BV2 was treated with one ng/ml LPS for 24 hours to stimulate. Results: LPS treatment increased the expression of SAA3 mRNA in BV2 microglial cells, while DDL pre-treatment inhibited LPS-induced SAA3 mRNA expression.Conclusion: Microglia cells treated with LPS display a significant reduction in the expression of SAA3 gene transcripts upon treatment with DDL

Osteoporosis in Mongolian Population: Prevalence and Risk Factors

Objectives: The purpose of this study was to evaluate the prevalence of osteoporosis and investigate some of its risk factors among Mongolian adults. Methods: The subjects comprised of 2001 adults (age ranged from 20 to 87) were recruited from 5 ecological zones of Mongolia. After applying exclusion criteria, 1990 subjects were selected. Speed of sound (SOS) ultrasonic bone mineral density was measured in the distal one third of radius of the non-dominant arm using the Sunlight Omnisense (Sunlight Medical, Rehovot, Israel). The data were used to calculate mean SOS and T-score by WHO osteoporosis criteria. Results: The average age was 49.1±13.5 (men: 48.6±14.6, women: 49.4±13.0). The prevalence of osteoporosis in men and women from 20-35 years of age was 4.7% vs 6.2%, from 36-45 years of age was 7.2% vs 8.0%, from ages 46-55 was 11.4% vs 25.5%, from ages 56-65 was 21.9% vs 58.3%, and from those over 65 years of age was 35.6% vs 75.5%. The prevalence of osteoporosis was lowest in Ulaanbaatar city. The independent predictors of osteoporosis in Mongolian adults were female sex, menopause, lower education level, physical inactivity and low BMI (BMI<18.5). Conclusion: Compared to neighboring and industrialized countries, the prevalence of osteoporosis in Mongolia is significantly higher. Female sex, lack of exercise, lower education level, menopause and being underweight were identified as risk factors in Mongolian adults

A study on structure and functions of organs involved in the formation of Mongolian Khuumii sound

Khuumii (throat or overtone singing) is a unique form of art derived from the nomadic population of Central Asia, which is a type of singing in which the singer manipulates the resonances (or formants) created as air travels from the lungs, past the vocal folds, and out of the lips to produce a melody. A total of 60 participants, aged 18-60 years (54 men and 6 women), were selected by non-random sampling method using cross-sectional study. X-ray, endoscopy, and sound research method were used in the study, and the composition of blood gas was analysed. X-ray examination determined the state during each different types of Khuumii; Shakhaa and Kharkhiraa. As the basic timbre of Shakhaa Khuumii went up progressively the larynx grew and the compression strength increased, while the basic timbre went down, and the larynx became lower. In the case of Kharkhiraa Khuumii, the larynx position was elevated to a relatively small extent compared to Shakhaa Khuumii and the distance between the sublingual bone and the larynx was large. The sublingual bone trunk lowered during Shakhaa Khuumii, while it was slightly elevated during Kharkhiraa Khuumii. The laryngeal endoscopy evaluated the movement of true and false vocal chords, glottal volume, movements of epiglottis and arytenoid cartilage, and mucosa. Furthermore, the sound frequency is 2-4 times higher than that of normal speech, and sound volume is 0.5-1 times higher. The blood gas composition test showed partial pressure (pO2), and saturation of oxygen (SaO2) decreased after performing Khuumii. In the case of Shakhaa and Kharkhiraa Khuumi, it is appropriate to divide Khuumii into two main types according to structural and functional changes in the organs involved

A study on structure and functions of organs involved in the formation of Mongolian Khuumii sound

Khuumii (throat or overtone singing) is a unique form of art derived from the nomadic population of Central Asia, which is a type of singing in which the singer manipulates the resonances (or formants) created as air travels from the lungs, past the vocal folds, and out of the lips to produce a melody. A total of 60 participants, aged 18-60 years (54 men and 6 women), were selected by non-random sampling method using cross-sectional study. X-ray, endoscopy, and sound research method were used in the study, and the composition of blood gas was analysed. X-ray examination determined the state during each different types of Khuumii; Shakhaa and Kharkhiraa. As the basic timbre of Shakhaa Khuumii went up progressively the larynx grew and the compression strength increased, while the basic timbre went down, and the larynx became lower. In the case of Kharkhiraa Khuumii, the larynx position was elevated to a relatively small extent compared to Shakhaa Khuumii and the distance between the sublingual bone and the larynx was large. The sublingual bone trunk lowered during Shakhaa Khuumii, while it was slightly elevated during Kharkhiraa Khuumii. The laryngeal endoscopy evaluated the movement of true and false vocal chords, glottal volume, movements of epiglottis and arytenoid cartilage, and mucosa. Furthermore, the sound frequency is 2-4 times higher than that of normal speech, and sound volume is 0.5-1 times higher. The blood gas composition test showed partial pressure (pO2), and saturation of oxygen (SaO2) decreased after performing Khuumii. In the case of Shakhaa and Kharkhiraa Khuumi, it is appropriate to divide Khuumii into two main types according to structural and functional changes in the organs involved

The association between blood glucose and oxidized lipoprotein(a) in healthy young women

<p>Abstract</p> <p>Background</p> <p>Oxidized lipoproteins play important roles in the atherosclerotic processes. Oxidized lipoprotein(a) (oxLp(a)) may be more potent in atherosclerotic pathophysiology than native Lp(a), a cardiovascular disease-relevant lipoprotein. Increased blood glucose concentrations can induce oxidative modification of lipoproteins. The aim of this study was to investigate the association between circulating oxLp(a) and cardiometabolic variables including blood glucose in healthy volunteers within the normal range of blood glucose.</p> <p>Methods</p> <p>Several cardiometabolic variables and serum oxLp(a) (using an ELISA system) were measured among 70 healthy females (mean age, 22 years).</p> <p>Results</p> <p>Lp(a) and glucose were significantly and positively correlated with oxLp(a) in simple correlation test. Furthermore, a multiple linear regression analysis showed oxLp(a) to have a weakly, but significantly positive and independent correlation with only blood glucose (<it>β </it>= 0.269, <it>P </it>< 0.05).</p> <p>Conclusions</p> <p>These results suggest that increased glucose may enhance the oxidization of Lp(a) even at normal glucose levels.</p