1,006 research outputs found

    Regional characteristics, opportunity perception and entrepreneurial activities

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    This paper seeks to better understand the link between regional characteristics and individual entrepreneurship. We combine individual-level GEM data for Western Germany with regional-level data, using multi-level analysis to test our hypotheses. We find no direct link between regional knowledge creation, the economic context and an entrepreneurial culture on the one side and individual business start-up intentions and start-up activity on the other side. However our findings point to the importance of an indirect effect of regional characteristics as knowledge creation, the economic context and an entrepreneurial culture have an effect on the individual perception of founding opportunities which in turn predicted start-up intentions and activity

    Evaluation of a Novel Anti-Mucin 1 (MUC1) Antibody (PankoMab) as a Potential Diagnostic Tool in Human Ductal Breast Cancer; Comparison with Two Established Antibodies

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    Aim: PankoMab is a novel antibody that recognizes a tumor-specific epitope of Mucin 1 (MUC1). The aim of this study was the evaluation of PankoMab as a potential diagnostic tool and its comparison with two established antibodies against MUC1 in human ductal breast cancer. Materials and Methods: Breast carcinomas were obtained from 82 patients. MUC1 expression and hormone receptor status were determined by immunohistochemistry of paraffin-embedded material. Results: PankoMab revealed strong correlation to hormone receptor expression. DF3 showed no correlation with grading, lymph node involvement and/or estrogen receptor (ER) expression. In the subgroup of lymph node-positive and ER-negative tumors, we saw a significantly reduced DF3 staining in G3 tumors compared to G2 tumors. VU-4-H5 showed increased staining intensity in correlation with increased grading. In addition, we also identified a significantly higher expression of the VU-4-H5 epitope in lymph node-positive carcinomas compared to carcinomas without lymph node involvement. Conclusion: PankoMab revealed strong correlation to hormone receptor expression in ductal carcinoma of the breast. VU-4-H5 showed increased staining intensity in correlation with increased grading and lymph node involvement. PankoMab and VU-4-H5 staining could be a useful combination in ductal breast cancer prognosis by immunohistochemistry

    Human hair follicle eqivalents in vitro for transplantation and chip-based substance testing : From 22nd European Society for Animal Cell Technology (ESACT) Meeting on Cell Based Technologies Vienna, Austria. 15-18 May 2011

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    First published by BioMed Central: Marx, Uwe ; Lindner, Gerd ; Wagner, Ilka ; Horland, Reyk ; Atac, Beren ; Hoffmann, Silke ; Gruchow, Mathias ; Sonntag, Frank ; Klotzbach, Udo ; Lauster, Roland: Human hair follicle equivalents in vitro for transplantation and chip-based substance testing : From 22nd European Society for Animal Cell Technology (ESACT) Meeting on Cell Based Technologies Vienna, Austria. 15-18 May 2011. - In: BMC Proceedings. - ISSN 1753-6561 (online). - 5 (2011), suppl. 8, O7. - doi:10.1186/1753-6561-5-S8-O7

    A bad following: the big five factors of personality and follower reactions to unethical leader behavior

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    Leadership research currently lacks significant attention to followership as an essential component of leadership. Existing literature addresses leader traits and behaviors more than those of followers, but also falls short by offering greater focus on ethical rather than unethical leadership. The current study attempts to fill this gap by examining not only followers as an overlooked yet essential influence, but also unethical leadership, particularly as it relates to follower perceptions of such behavior. The investigation uses follower personality (defined by the Big Five Factor Personality Dimensions) as a potential predictor for follower support or rejection of unethical leadership. Findings of this study indicate that extraversion, conscientiousness, agreeableness and openness in followers are significantly correlated with follower rejection of unethical leader behavior. Neuroticism was not significantly related to either acceptance or rejection of unethical leader behavior. The implications of these findings are considered

    Dynamic culture of human liver equivalents inside a micro-bioreactor for long-term substance testing : From 23rd European Society for Animal Cell Technology (ESACT) Meeting: Better Cells for Better Health Lille, France. 23-26 June 2013

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    Published by BioMed Central: Materne, Eva-Maria et al.: Dynamic culture of human liver equivalents inside a micro-bioreactor for longterm substance testing. - In: BMC Proceedings. - ISSN 1753-6561 (online). - 7 (2012), suppl. 6, art. P72. - doi:10.1186/1753-6561-7-S6-P72

    Peronospora verbenae sp. nov.: a new downy mildew on Verbena officinalis

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    BRAUN, U., JAGE, H., RICHTER, U. & ZIMMERMANN, H. 2009: Peronospora verbenae sp. nov. – ein neuer Falscher Mehltau auf Verbena officinalis. Schlechtendalia 19: 77– 80. Die neue Art Peronospora verbenae (Chromista, Oomycetes, Peronosporales) auf Verbena officinalis aus Deutschland wird beschrieben, abgebildet und diskutiert.BRAUN, U., JAGE, H., RICHTER, U. & ZIMMERMANN, H. 2009: Peronospora verbenae sp. nov. – a new downy mildew on Verbena officinalis. Schlechtendalia 19: 77– 80. The new species Peronospora verbenae (Chromista, Oomycetes, Peronosporales) on Verbena officinalis from Germany is described, illustrated and discussed.Die Schlechtendalia publiziert Originalbeiträge mit Schwerpunkt Spezielle Botanik und Biodiversität, Floristik, Mykologie/Lichenologie, Wissenschaftsgeschichte und andere Themen mit Bezug zu Botanischen Gärten und Herbarien

    Comparative tests - help for the development of teaching? Central comparative tests of the learning level in the eyes of teachers from Baden-Wuerttemberg

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    Vergleichsarbeiten sollen Lehrkräften eine objektive Rückmeldung über den Lernstand ihrer Schüler geben und zu einer ergebnisorientierten Unterrichtsentwicklung beitragen. ... In Baden-Württemberg wurden erstmals gegen Ende des Schuljahres 2005/06 verpflichtende Vergleichsarbeiten in den Klassen 6 und 8 der weiterführenden Schulen und Diagnosearbeiten in der Grundschulklasse 2 durchgeführt. Aber werden Vergleichsarbeiten von den Lehrkräften akzeptiert und in der erwarteten Weise genutzt? ... In zwei repräsentativen Lehrerbefragungen [wurde] die Akzeptanz und der pädagogische Nutzen zentraler Lernstandserhebungen aus Lehrerperspektive in Abhängigkeit der bisher gemachten Testerfahrungen erhoben. Die Befragung... war Teil einer längsschnittlich angelegten Studie zur Einführung von Bildungsstandards in Baden-Württemberg. (DIPF/Orig.)Comparative tests should give objective feedback about the learning level of the students and contribute to the development of teaching oriented on results. In a representative study questioning teachers in Baden-Wuerttemberg central tests were judged predominantly positively, but that these new instruments of the educational policy will improve teaching seem to be dreams of the future. (DIPF/Orig.

    Classical conditioned responses to absent tones

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    BACKGROUND: Recent evidence for a tight coupling of sensorimotor processes in trained musicians led to the question of whether this coupling extends to preattentively mediated reflexes; particularly, whether a classically conditioned response in one of the domains (auditory) is generalized to another (tactile/motor) on the basis of a prior association in a second-order Pavlovian paradigm. An eyeblink conditioning procedure was performed in 17 pianists, serving as a model for overlearned audiomotor integration, and 14 non-musicians. Results: During the training session, subjects were conditioned to respond to auditory stimuli (piano tones). During a subsequent testing session, when subjects performed keystrokes on a silent piano, pianists showed significantly higher blink rates than non-musicians. CONCLUSION: These findings suggest a tight coupling of the auditory and motor domains in musicians, pointing towards training-dependent mechanisms of strong cross-modal sensorimotor associations even on sub-cognitive processing levels

    Interdisciplinary curricula in secondary education. How do teachers assess the recently combined subjects?

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    Im fächerübergreifenden Unterricht sollen Schüler bedeutungsvolles und anwendungsfähiges Wissen erwerben. Die bildungspolitischen Vorgaben in diesem Bereich unterscheiden sich erheblich von Bundesland zu Bundesland. In einer empirischen Studie wird erkundet, wie Lehrkräfte in Baden-Württemberg die dort entwickelten Fächerverbünde einschätzen. (DIPF/Orig.)Interdisciplinary teaching in secondary education aims to provide more meaningful learning environments for all students. Educational policy in this field differs from state to state. This empirical study examines how teachers in Baden-Württemberg view the recently combined subjects in secondary schools. (DIPF/Orig.
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