Feeding pigs in organic farming

The technical booklet "Feeding pigs in organic farming" is intended for farmers and advisors. It is based on the results of four research projects and provides a synthesis of information on e.g. the regulations concerning the feeding of organic pigs, feeding management and the needs of animals according to their physiological stage. Furthermore, it includes information on the nutritive value of organic raw materials, examples of diet formulation and expected performances, the use of feedstuff and its manufacturing on the farm. This document has been produced specifically for organic farming but may be useful for all pig farmers. It can be used regardless of a farm's location

Gender, racialisation, and border regimes: reflections on social positions and positioning in research with young people on the move

This article starts from our experiences as two Western women of Black mixed-race background, undertaking fieldwork among unaccompanied young men on the move in Europe. We add to scholarship on ethnographic accounts of encounters. We do this by reflecting on how our positionality affected the research process along often taken-for-granted social categories and markers of sameness and difference, as they related to our fieldwork and the space created between us and participants. We analyse the ways in which power is infused along multiple intersecting axes such as gender and race, and is imbued with movement in that space, helping people to feel, among other things, safe and unsafe, located and dislocated, and visible and invisible. We find that the social positions and positioning that emerged were tied into vulnerabilities related to gender and age, legal status, dimensions of race, class, and specific histories and imaginaries. We also show how performativity, shifting boundaries, and othering came into play and shaped bordering practices and a sense of belonging.acceptedVersio

Rapport de mission en République arabe du Yémen, 7-15 mai 1977

Une mission d'industriels français s'est rendue au Yémen du Nord du 7 au 15 mai 1977, à l'initiative du CFCE. Le Ceemat participait à la mission au titre de représentant du Syndicat général des constructeurs de tracteurs et de machines agricoles. Aucun constructeur de la profession ne faisait partie de la mission. Pays essentiellement agricole, le Yémen est un gros producteur de céréales - environ 2 millions de tonnes - par rapport à sa superficie et à sa population. L'agriculture reste très sous-équipée. Le marché des tracteurs semble se développer brusquement depuis peu puisqu'en deux ans les importations passent de 114 à environ 1500 unités. Les tracteurs livrés sont équipés le plus souvent de charrues monosoc ; de gros progrès sont à faire pour améliorer leur utilisation. Le marché du motoculteur est pratiquement inexistant mais tout laisse croire que ce marché pourra devenir important si les Constructeurs intéressés font l'effort nécessaire pour présenter du matériel bien adapté aux zones montagneuses. Le matériel à traction animale est déjà connu sous la forme d'araires traditionnels ; il pourrait se développer en proposant des gammes diversifiées de matériel. Les batteuses à céréales simples 3 transportables semblent assurées d'un débouché important et immédiat. Les rompes à moteur sont déjà largement connues. D'autres équipements présentent de l'intérêt. Les plus simples pourraient faire l'objet de fabrication locale. Les industriels intéressés peuvent prendre directement contact avec les firmes yéménites mentionnées en annexe. Le vice-président de la Chambre de commerce de Sanaa sera à Paris vers la mi-juin 1977. Il est prêt à cette occasion à rencontrer des industriels français par l'entremise du CFCE. Un programme minimum de coopération technique appliqué au machinisme agricole pourrait étayer la prospection commerciale. Par exemple des essais et démonstrations pourraient être organiser pour les motoculteurs et les matériels à traction animale. Des structures adéquates ont été identifiées pour servir de support à ces actions

Comparative proteomics and functional analysis reveal a role of plasmodium falciparum osmiophilic bodies in malaria parasite transmission

An essential step in the transmission of the malaria parasite to the Anopheles vector is the transformation of the mature gametocytes into gametes in the mosquito gut, where they egress from the erythrocytes and mate to produce a zygote, which matures into a motile ookinete. Osmiophilic bodies are electron dense secretory organelles of the female gametocytes which discharge their contents during gamete formation, suggestive of a role in gamete egress. Only one protein with no functional annotation, Pfg377, is described to specifically reside in osmiophilic bodies in Plasmodium falciparum. Importantly, Pfg377 defective gametocytes lack osmiophilic bodies and fail to infect mosquitoes, as confirmed here with newly produced pfg377 disrupted parasites. The unique feature of Pfg377 defective gametocytes of lacking osmiophilic bodies was here exploited to perform comparative, label free, global and affinity proteomics analyses of mutant and wild type gametocytes to identify components of these organelles. Subcellular localization studies with fluorescent reporter gene fusions and specific antibodies revealed an osmiophilic body localization for four out of five candidate gene products analyzed: the proteases PfSUB2 (subtilisin 2) and PfDPAP2 (Dipeptidyl aminopeptidase 2), the ortholog of the osmiophilic body component of the rodent malaria gametocytes PbGEST and a previously non-annotated 13 kDa protein. These results establish that osmiophilic bodies and their components are dispensable or marginally contribute (PfDPAP2) to gamete egress. Instead, this work reveals a previously unsuspected role of these organelles in P. falciparum development in the mosquito vector

EVIDENCE OF PRIMARY EVENTS IN 20Ne, 22Ne FRAGMENTATION FROM COINCIDENCE MEASUREMENTS IN 20, 22Ne + 93Nb REACTION AT 30 MeV/A

Evidence that primary ejectiles formation strongly depends on the projectile structure is given by comparison of 20Ne + 93Nb and 22Ne + 93Nb reactions at 30 MeV/A. Pick-up, stripping, break-up mechanism are identified using light particles-projectile fragments coïncidence measurements

An Upstream Finite Volume Scheme for a Bone Healing Model

This paper is devoted to the introduction of a numerical scheme for a bone healing model and simulation of skull fractures. The mathematical model describes the evolution of mesenchymal stem cells, osteoblasts, bone matrix and osteogenic growth factor. We propose a numerical scheme based on an implicit finite volume method constructed on an orthogonal mesh. The efficiency and robustness of the scheme are shown in simulating a skull fracture in rats

Pentamidine Is Not a Permeant but a Nanomolar Inhibitor of the Trypanosoma brucei Aquaglyceroporin-2

The chemotherapeutic arsenal against human African trypanosomiasis, sleeping sickness, is limited and can cause severe, often fatal, side effects. One of the classic and most widely used drugs is pentamidine, an aromatic diamidine compound introduced in the 1940s. Recently, a genome-wide loss-of-function screen and a subsequently generated trypanosome knockout strain revealed a specific aquaglyceroporin, TbAQP2, to be required for high-affinity uptake of pentamidine. Yet, the underlying mechanism remained unclear. Here, we show that TbAQP2 is not a direct transporter for the di-basic, positively charged pentamidine. Even though one of the two common cation filters of aquaglyceroporins, i.e. the aromatic/arginine selectivity filter, is unconventional in TbAQP2, positively charged compounds are still excluded from passing the channel. We found, instead, that the unique selectivity filter layout renders pentamidine a nanomolar inhibitor of TbAQP2 glycerol permeability. Full, non-covalent inhibition of an aqua(glycero)porin in the nanomolar range has not been achieved before. The remarkable affinity derives from an electrostatic interaction with Asp265 and shielding from water as shown by structure-function evaluation and point mutation of Asp265. Exchange of the preceding Leu264 to arginine abolished pentamidine-binding and parasites expressing this mutant were pentamidine-resistant. Our results indicate that TbAQP2 is a high-affinity receptor for pentamidine. Taken together with localization of TbAQP2 in the flagellar pocket of bloodstream trypanosomes, we propose that pentamidine uptake is by endocytosis

APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin

The C-terminal variants G1 and G2 of apolipoprotein L1 (APOL1) confer human resistance to the sleeping sickness parasite Trypanosoma rhodesiense, but they also increase the risk of kidney disease. APOL1 and APOL3 are death-promoting proteins that are partially associated with the endoplasmic reticulum and Golgi membranes. We report that in podocytes, either APOL1 C-terminal helix truncation (APOL1Δ) or APOL3 deletion (APOL3KO) induces similar actomyosin reorganization linked to the inhibition of phosphatidylinositol-4-phosphate [PI(4)P] synthesis by the Golgi PI(4)-kinase IIIB (PI4KB). Both APOL1 and APOL3 can form K+ channels, but only APOL3 exhibits Ca2+-dependent binding of high affinity to neuronal calcium sensor-1 (NCS-1), promoting NCS-1-PI4KB interaction and stimulating PI4KB activity. Alteration of the APOL1 C-terminal helix triggers APOL1 unfolding and increased binding to APOL3, affecting APOL3-NCS-1 interaction. Since the podocytes of G1 and G2 patients exhibit an APOL1Δ or APOL3KO-like phenotype, APOL1 C-terminal variants may induce kidney disease by preventing APOL3 from activating PI4KB, with consecutive actomyosin reorganization of podocytes.info:eu-repo/semantics/publishe

The impact of arterial flow complexity on flow diverter outcomes in aneurysms

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The development of an analytical framework to compare reception structures for unaccompanied refugee minors in Europe

The UN Convention of the Rights of the Child stipulates that unaccompanied refugee minors (URM) are entitled to specific and adapted accommodation structures and care. Despite the general strive in EU policy to reach common standards for those reception structures, they still vary largely, resulting in unequal treatment and care conditions. In this article, we aim to build an analytical framework, based on central features of concrete reception practices in different EU countries, which can serve as a tool for in-depth comparative researches of reception and care systems. Starting from the comparative framework of Watters and Hossain [(2008). Policy in practice: Reception practices and minimum standards (End report for ARG project)], we draw a new framework on reception structures for URM based on insights from various disciplines and extensive participant observations in 58 accommodation settings for this group in different EU Member States. Our framework includes four analytical axes: (1) separation versus integration; (2) control versus autonomy; (3) immigration control versus welfare protection; and (4) low intensity versus high intensity care and illustrates how organisational arrangements and choices made within the different axes strongly influence the realisation of care and support. As such, this framework may serve as a first, necessary step in creating increased evidence on how reception structures may impact URM’ well-being