Meaningful Toxicology

The scope of toxicology, therefore, may extend from the study of a single element such as lead to a complex, chemically uncharacterized substance such as snake venom; from an overdose of heroin to the effects of long-term exposure to low levels of pesticides on anticonvulsant therapy. For the purpose of this discussion, we shall narrow the limits of the broad field of toxicology considerably, but it is important to be aware of the breadth and depth to which toxicology may at times extend

Adaptive Observer for Nonlinearly Parameterised Hammerstein System with Sensor Delay – Applied to Ship Emissions Reduction

Taking offspring in a problem of ship emission reduction by exhaust gas recirculation control for large diesel engines, an underlying generic estimation challenge is formulated as a problem of joint state and parameter estimation for a class of multiple-input single-output Hammerstein systems with first order dynamics, sensor delay and a bounded time-varying parameter in the nonlinear part. The paper suggests a novel scheme for this estimation problem that guarantees exponential convergence to an interval that depends on the sensitivity of the system. The system is allowed to be nonlinear parameterized and time dependent, which are characteristics of the industrial problem we study. The approach requires the input nonlinearity to be a sector nonlinearity in the time-varying parameter. Salient features of the approach include simplicity of design and implementation. The efficacy of the adaptive observer is shown on simulated cases, on tests with a large diesel engine on test bed and on tests with a container vessel

The Impact of a 4th Generation on Mixing and CP Violation in the Charm System

We study D0-D0 mixing in the presence of a fourth generation of quarks. In particular, we calculate the size of the allowed CP violation which is found at the observable level well beyond anything possible with CKM dynamics. We calculate the semileptonic asymmetry a_SL and the mixing induced CP asymmetry eta_fS_f which are correlated with each other. We also investigate the correlation of eta_fS_f with a number of prominent observables in other mesonic systems like epsilon'/epsilon, Br(K_L -> pi0 nu nu), Br(K+ -> pi+ nu nu), Br(B_s ->mu+ mu-), Br(B_d -> mu+ mu-) and finally S_psi phi in the B_s system. We identify a clear pattern of flavour and CP violation predicted by the SM4 model: While simultaneous large 4G effects in the K and D systems are possible, accompanying large NP effects in the B_d system are disfavoured. However this behaviour is not as pronounced as found for the LHT and RSc models. In contrast to this, sizeable CP violating effects in the B_s system are possible unless extreme effects in eta_fS_f are found, and Br(B_s ->mu+ mu-) can be strongly enhanced regardless of the situation in the D system. We find that, on the other hand, S_psi phi > 0.2 combined with the measured epsilon'/epsilon significantly diminishes 4G effects within the D system.Comment: 22 pages, 23 figures, v2 (references added

Phenomenology of a three-family model with gauge symmetry SU(3)_c X SU(4)_L X U(1)_X

We study an extension of the gauge group SU(3)_c X SU(2)_L X U(1)_Y of the standard model to the symmetry group SU(3)_c X SU(4)_L X U(1)_X (3-4-1 for short). This extension provides an interesting attempt to answer the question of family replication in the sense that models for the electroweak interaction can be constructed so that anomaly cancellation is achieved by an interplay between generations, all of them under the condition that the number of families must be divisible by the number of colours of SU(3)_c. This method of anomaly cancellation requires a family of quarks transforming differently from the other two, thus leading to tree-level flavour changing neutral currents (FCNC) transmitted by the two extra neutral gauge bosons $Z'$ and $Z''$ predicted by the model. In a version of the 3-4-1 extension, which does not contain particles with exotic electric charges, we study the fermion mass spectrum and some aspects of the phenomenology of the neutral gauge boson sector. In particular, we impose limits on the $Z-Z'$ mixing angle and on the mass scale of the corresponding physical new neutral gauge boson $Z_2$, and establish a lower bound on the mass of the additional new neutral gauge boson $Z'' \equiv Z_3$. For the analysis we use updated precision electroweak data at the Z-pole from the CERN LEP and SLAC Linear Collider, and atomic parity violation data. The mass scale of the additional new neutral gauge boson $Z_3$ is constrained by using updated experimental inputs from neutral meson mixing in the analysis of the sources of FCNC in the model. The data constrain the $Z-Z'$ mixing angle to a very small value of O(0.001), and the lower bounds on $M_{Z_2}$ and on $M_{Z_3}$ are found to be of O(1 TeV) and of O(7 TeV), repectively.Comment: 22 pages, 6 tables, 1 figure. To appear in J. Phys. G: Nuclear and Particle Physic

Waiting for Precise Measurements of K^+->pi^+ nu nu and K_L->pi^0 nu nu

In view of future plans for accurate measurements of the theoretically clean branching ratios Br(K+ -> pi+ nu nu) and Br(KL -> pi0 nu nu), that should take place in the next decade, we collect the relevant formulae for quantities of interest and analyze their theoretical and parametric uncertainties. We point out that in addition to the angle beta in the unitarity triangle (UT) also the angle gamma can in principle be determined from these decays with respectable precision and emphasize in this context the importance of the recent NNLO QCD calculation of the charm contribution to K+ -> pi+ nu nu and of the improved estimate of the long distance contribution by means of chiral perturbation theory. In addition to known expressions we present several new ones that should allow transparent tests of the Standard Model (SM) and of its extensions. While our presentation is centered around the SM, we also discuss models with minimal flavour violation and scenarios with new complex phases in decay amplitudes and meson mixing. We give a brief review of existing results within specific extensions of the SM, in particular the Littlest Higgs Model with T-parity, Z' models, the MSSM and a model with one universal extra dimension. We derive a new "golden" relation between B and K systems that involves (beta,gamma) and Br(KL -> pi0 nu nu) and investigate the virtues of (R_t,beta), (R_b,gamma), (beta,gamma) and (etabar,gamma) strategies for the UT in the context of K -> pi nu nu decays with the goal of testing the SM and its extensions.Comment: 56 pages, 18 figures, Section on Long Distance Contributions, 2 Figures and few References added, Uses Rev Mod Phys Style; Includes new results of NNLO calculation as well as matrix elements, extended and modified sections on new physic

Pair production of the T-odd leptons at the LHC

The T-odd leptons predicted by the littlest $Higgs$ model with T-parity can be pair produced via the subprocesses $gg\to \ell^{+}_{H}\ell^{-}_{H}$, $q\bar{q}\to \ell^{+}_{H}\ell^{-}_{H}$, $\gamma\gamma\to \ell^{+}_{H}\ell^{-}_{H}$ and $VV \to \ell^{+}_{H}\ell^{-}_{H}$ ($V$=$W$ or $Z$) at the $CERN$ Large Hadron Collider $(LHC)$. We estimate the hadronic production cross sections for all of these processes and give a simply phenomenology analysis. We find that the cross sections for most of the above processes are very small. However, the value of the cross section for the $Drell-Yan$ process $q\bar{q}\to \ell^{+}_{H}\ell^{-}_{H}$ can reach $270fb$.Comment: 12 pages, 2 figure

Lepton flavor violation decays τ−→μ−P1P2\tau^-\to \mu^- P_1 P_2 in the topcolor-assisted technicolor model and the littlest Higgs model with TT parity

The new particles predicted by the topcolor-assisted technicolor ($TC2$) model and the littlest Higgs model with T-parity (called $LHT$ model) can induce the lepton flavor violation ($LFV$) couplings at tree level or one loop level, which might generate large contributions to some $LFV$ processes. Taking into account the constraints of the experimental data on the relevant free parameters, we calculate the branching ratios of the $LFV$ decay processes $\tau^-\to\mu^- P_1 P_2$ with $P_1 P_2$ = $\pi^+\pi^-$, $K^+K^-$ and $K^0\bar{K^0}$ in the context of these two kinds of new physics models. We find that the $TC2$ model and the $LHT$ model can indeed produce significant contributions to some of these $LFV$ decay processes.Comment: 24 pages, 7 figure

The Physics of Heavy Flavours at SuperB

This is a review of the SuperB project, covering the accelerator, detector, and highlights of the broad physics programme. SuperB is a flavour factory capable of performing precision measurements and searches for rare and forbidden decays of $B_{u,d,s}$, $D$, $\tau$ and $\Upsilon({\mathrm{nS}})$ particles. These results can be used to test fundamental symmetries and expectations of the Standard Model, and to constrain many different hypothesised types of new physics. In some cases these measurements can be used to place constraints on the existence of light dark matter and light Higgs particles with masses below $10GeV/c^2$. The potential impact of the measurements that will be made by SuperB on the field of high energy physics is also discussed in the context of data taken at both high energy in the region around the \Upsilon({\mathrm{4S}})$, and near charm threshold.Comment: 49 pages, topical review submitted to J. Phys

Robots that can adapt like animals

As robots leave the controlled environments of factories to autonomously function in more complex, natural environments, they will have to respond to the inevitable fact that they will become damaged. However, while animals can quickly adapt to a wide variety of injuries, current robots cannot "think outside the box" to find a compensatory behavior when damaged: they are limited to their pre-specified self-sensing abilities, can diagnose only anticipated failure modes, and require a pre-programmed contingency plan for every type of potential damage, an impracticality for complex robots. Here we introduce an intelligent trial and error algorithm that allows robots to adapt to damage in less than two minutes, without requiring self-diagnosis or pre-specified contingency plans. Before deployment, a robot exploits a novel algorithm to create a detailed map of the space of high-performing behaviors: This map represents the robot's intuitions about what behaviors it can perform and their value. If the robot is damaged, it uses these intuitions to guide a trial-and-error learning algorithm that conducts intelligent experiments to rapidly discover a compensatory behavior that works in spite of the damage. Experiments reveal successful adaptations for a legged robot injured in five different ways, including damaged, broken, and missing legs, and for a robotic arm with joints broken in 14 different ways. This new technique will enable more robust, effective, autonomous robots, and suggests principles that animals may use to adapt to injury

An Improved Standard Model Prediction Of BR(B -> tau nu) And Its Implications For New Physics

The recently measured B -> tau nu branching ratio allows to test the Standard Model by probing virtual effects of new heavy particles, such as a charged Higgs boson. The accuracy of the test is currently limited by the experimental error on BR(B -> tau nu) and by the uncertainty on the parameters fB and |Vub|. The redundancy of the Unitarity Triangle fit allows to reduce the error on these parameters and thus to perform a more precise test of the Standard Model. Using the current experimental inputs, we obtain BR(B -> tau nu)_SM = (0.84 +- 0.11)x10^{-4}, to be compared with BR(B -> tau nu)_exp = (1.73 +- 0.34)x10^{-4}. The Standard Model prediction can be modified by New Physics effects in the decay amplitude as well as in the Unitarity Triangle fit. We discuss how to disentangle the two possible contributions in the case of minimal flavour violation at large tan beta and generic loop-mediated New Physics. We also consider two specific models with minimal flavour violation: the Type-II Two Higgs Doublet Model and the Minimal Supersymmetric Standard Model.Comment: 7 pages, 13 figures, 1 table. v2: added references and discussion of B -> D tau nu in the 2HDM. v3: added Bs->mumu in the 2HDM. Final version to appear in PL