Multiphysics Finite\u2013Element Modelling of an All\u2013Vanadium Redox Flow Battery for Stationary Energy Storage

All-Vanadium Redox Flow Batteries (VRFBs) are emerging as a novel technology for stationary energy storage. Numerical models are useful for exploring the potential performance of such devices, optimizing the structure and operating condition of cell stacks, and studying its interfacing to the electrical grid. A one-dimensional steady-state multiphysics model of a single VRFB, including mass, charge and momentum transport and conservation, and coupled to a kinetic model for electrochemical reactions, is first presented. This model is then extended, including reservoir equations, in order to simulate the VRFB charge and discharge dynamics. These multiphysics models are discretized by the finite element method in a commercial software package (COMSOL). Numerical results of both static and dynamic 1D models are compared to those from 2D models, with the same parameters, showing good agreement. This motivates the use of reduced models for a more efficient system simulation

Altered Kv2.1 functioning promotes increased excitability in hippocampal neurons of an Alzheimer's disease mouse model.

Altered neuronal excitability is emerging as an important feature in Alzheimer's disease (AD). Kv2.1 potassium channels are important modulators of neuronal excitability and synaptic activity. We investigated Kv2.1 currents and its relation to the intrinsic synaptic activity of hippocampal neurons from 3xTg-AD (triple transgenic mouse model of Alzheimer's disease) mice, a widely employed preclinical AD model. Synaptic activity was also investigated by analyzing spontaneous [Ca(2+)]i spikes. Compared with wild-type (Non-Tg (non-transgenic mouse model)) cultures, 3xTg-AD neurons showed enhanced spike frequency and decreased intensity. Compared with Non-Tg cultures, 3xTg-AD hippocampal neurons revealed reduced Kv2.1-dependent Ik current densities as well as normalized conductances. 3xTg-AD cultures also exhibited an overall decrease in the number of functional Kv2.1 channels. Immunofluorescence assay revealed an increase in Kv2.1 channel oligomerization, a condition associated with blockade of channel function. In Non-Tg neurons, pharmacological blockade of Kv2.1 channels reproduced the altered pattern found in the 3xTg-AD cultures. Moreover, compared with untreated sister cultures, pharmacological inhibition of Kv2.1 in 3xTg-AD neurons did not produce any significant modification in Ik current densities. Reactive oxygen species (ROS) promote Kv2.1 oligomerization, thereby acting as negative modulator of the channel activity. Glutamate receptor activation produced higher ROS levels in hippocampal 3xTg-AD cultures compared with Non-Tg neurons. Antioxidant treatment with N-Acetyl-Cysteine was found to rescue Kv2.1-dependent currents and decreased spontaneous hyperexcitability in 3xTg-AD neurons. Analogous results regarding spontaneous synaptic activity were observed in neuronal cultures treated with the antioxidant 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox). Our study indicates that AD-related mutations may promote enhanced ROS generation, oxidative-dependent oligomerization, and loss of function of Kv2.1 channels. These processes can be part on the increased neuronal excitability of these neurons. These steps may set a deleterious vicious circle that eventually helps to promote excitotoxic damage found in the AD brain

Influence of laser-lok surface on immediate functional loading of implants in single-tooth replacement: a 2-year prospective clinical study.

he purpose of this study was to evaluate the influence of a Laser-Lok microtexturing surface on clinical attachment level and crestal bone remodeling around immediately functionally loaded implants in single-tooth replacement. Seventy-seven patients were included in a prospective, randomized study and divided into two groups. Group 1 (control) consisted of non-Laser-Lok type implants (n = 39), while in group 2 (test), Laser-Lok type implants were used (n = 39). Crestal bone loss (CBL) and clinical parameters including clinical attachment level (CAL), Plaque Index (PI), and bleeding on probing were recorded at baseline examinations and at 6, 12, and 24 months after loading with the final restoration. One implant was lost in the control group and one in the test group, giving a total survival rate of 96.1% after 2 years. PI and BOP outcomes were similar for both implant types without statistical differences. A mean CAL loss of 1.10 ± 0.51 mm was observed during the first 2 years in group 1, while the mean CAL loss observed in group 2 was 0.56 ± 0.33 mm. Radiographically, group 1 implants showed a mean crestal bone loss of 1.07 ± 0.30 mm compared with 0.49 ± 0.34 mm for group 2. The type of implant did not influence the survival rate, whereas Laser-Lok implants resulted in greater CAL and in shallower radiographic peri-implant CBL than non-Laser-Lok implants

FAVOR (FAst Variability Optical Registration) -- A Two-telescope Complex for Detection and Investigation of Short Optical Transients

An astronomical complex intended to detect optical transients (OTs) in a wide field and follow them up with high time resolution investigation is described.Comment: 4 pages, 3 figures. To be published in "Il Nuovo Cimento", Proceedings of the 4th Rome Workshop on Gamma-Ray Bursts in the Afterglow Era, eds. L. Piro, L. Amati, S. Covino, B. Gendr

V, J, H and K Imaging of the Metal Rich Globular Cluster NGC 6528

New near-infrared observations of NGC6528 are presented. The JHK observations complement a previous HST/NICMOS data set by Ortolani et al. (2001), in that they sample a larger area, contain a more numerous sample of red giant stars, and include the K band. Also, archival HST data sets (separated by 6.093 years) were used to proper-motion decontaminate the near-infrared sample and extract a clean VJHK catalogue. Using the present wide colour baseline, we compared the cleaned colour-magnitude diagrams of NGC6528 with those of NGC 6553 and NGC104 and derived new estimates of reddening and distance, E(B-V)=0.55 and (m-M)o=14.44 (7.7 kpc). Moreover, the morphology and location of the cleaned red giant branch were used to derive a photometric estimate of the cluster metallicity. The average of 10 metallicity indicators yields a mean value of [M/H] ~ 0.0, and [Fe/H] ~-0.20 and +0.08 on the Zinn & West (1984) and Carretta & Gratton (1997) revised metallicity scale, respectively. The best isochrone fit to the cleaned K,V-K diagram is obtained for a 12.6 Gyr and Z=0.02 isochrone, i.e. the derived metallicity of NGC6528 turns out to be very close to the mean of stars in the Baade's Window. Five AGB variable star candidates, whose membership has to be confirmed spectroscopically, are bolometrically as bright as the known long period variable stars in NGC6553. As discussed in Guarnieri et al. (1997) for NGC6553, this may indicate that an `intermediate age' population is not needed to account for the brightest stars in external galaxies such as M32.Comment: 11 pages, 9 figures, A&A accepte

Are we ready for scaling up restoration actions? An insight from Mediterranean macroalgal canopies

Extensive loss of macroalgal forests advocates for large-scale restoration interventions, to compensate habitat degradation and recover the associated ecological functions and services. Yet, restoration attempts have generally been limited to small spatial extensions, with the principal aim of developing efficient restoration techniques. Here, the success of outplanting Cystoseira amentacea v. stricta germlings cultured in aquaria was experimentally explored at a scale of tens of kms, by means of a multifactorial experimental design. In the intertidal rocky shores of SE Italy, locations with a continuous distribution for hundreds of meters or with few thalli forming patches of few centimeters of C. amentacea canopy were selected. In each location, the effects of adult conspecifics and the exclusion of macrograzers (salema fish and sea urchins) on the survival of germlings were tested. We evaluated the most critical determinants of mortality for germlings, including the overlooked pressure of mesograzers (e.g. amphipods, small mollusks, polychaetes). Despite the high mortality observed during outplanting and early settlement stages, survival of C. amentacea germlings was consistently favored by the exclusion of macrograzers, while the presence of adult conspecifics had no effects. In addition, the cost analysis of the interventions showed the feasibility of the ex-situ method, representing an essential tool for preserving Cystoseira forests. Large scale restoration is possible but requires baseline information with an in-depth knowledge of the species ecology and of the areas to be restored, together with the development of specific cultivation protocols to make consistently efficient restoration interventions

Implications of the Visible and X-Ray Counterparts to GRB970228

The gamma-ray burst source GRB970228 has been observed after a delay of 8--12 hours in X-rays and after one day in visible and near infrared light. This marks the first detection of emission at lower frequencies following the gamma-ray observation of a GRB and the first detection of any visible counterpart to a GRB. We consider possible delayed visible and X-ray emission mechanisms, and conclude that the intrinsic gamma-ray activity continued at a much reduced intensity for at least a day. There are hints of such continued activity in other GRB, and future observations can decide if this is true of GRB in general. The observed multi-band spectrum of GRB970228 agrees with the predictions of relativistic shock theory when the flux is integrated over a time longer than that required for a radiating electron to lose its energy.Comment: 5 pp., tex, 1 figur

Studies of ionospheric F-region response in the Latin American sector during the geomagnetic storm of 21–22 January 2005

In the present investigation, we have studied the response of the ionospheric F-region in the Latin American sector during the intense geomagnetic storm of 21–22 January 2005. This geomagnetic storm has been considered "anomalous" (minimum Dst reached −105 nT at 07:00 UT on 22 January) because the main storm phase occurred during the northward excursion of the B_z component of interplanetary magnetic fields (IMFs). The monthly mean <i>F</i>_10.7 solar flux for the month of January 2005 was 99.0 sfu. The F-region parameters observed by ionosondes at Ramey (RAM; 18.5° N, 67.1° W), Puerto Rico, Jicamarca (JIC; 12.0° S, 76.8° W), Peru, Manaus (MAN; 2.9° S, 60.0° W), and São José dos Campos (SJC; 23.2° S, 45.9° W), Brazil, during 21–22 January (geomagnetically disturbed) and 25 January (geomagnetically quiet) have been analyzed. Both JIC and MAN, the equatorial stations, show unusually rapid uplifting of the F-region peak heights (<i>hp</i>F2/<i>hm</i>F2) and a decrease in the <i>Nm</i>F2 coincident with the time of storm sudden commencement (SSC). The observed variations in the F-region ionospheric parameters are compared with the TIMEGCM model run for 21–22 January and the model results show both similarities and differences from the observed results. Average GPS-TEC (21, 22 and 25 January) and phase fluctuations (21, 22, 25, 26 January) observed at Belem (BELE; 1.5° S, 48.5° W), Brasilia (BRAZ; 15.9° S, 47.9° W), Presidente Prudente (UEPP; 22.3° S, 51.4° W), and Porto Alegre (POAL; 30.1° S, 51.1° W), Brazil, are also presented. These GPS stations belong to the RBMC/IBGE network of Brazil. A few hours after the onset of the storm, large enhancements in the VTEC and <i>Nm</i>F2 between about 20:00 and 24:00 UT on 21 January were observed at all the stations. However, the increase in VTEC was greatest at the near equatorial station (BELE) and enhancements in VTEC decreased with latitude. It should be pointed out that no phase fluctuations or spread-F were observed in the Latin American sector during the post-sunset pre-reversal time in the geomagnetic disturbance (21 January). The disturbance dynamo electric field possibly resulted in downward drift of the F-region plasma and inhibited the formation of spread-F

The ALTCRISS project on board the International Space Station

The Altcriss project aims to perform a long term survey of the radiation environment on board the International Space Station. Measurements are being performed with active and passive devices in different locations and orientations of the Russian segment of the station. The goal is to perform a detailed evaluation of the differences in particle fluence and nuclear composition due to different shielding material and attitude of the station. The Sileye-3/Alteino detector is used to identify nuclei up to Iron in the energy range above 60 MeV/n. Several passive dosimeters (TLDs, CR39) are also placed in the same location of Sileye-3 detector. Polyethylene shielding is periodically interposed in front of the detectors to evaluate the effectiveness of shielding on the nuclear component of the cosmic radiation. The project was submitted to ESA in reply to the AO in the Life and Physical Science of 2004 and data taking began in December 2005. Dosimeters and data cards are rotated every six months: up to now three launches of dosimeters and data cards have been performed and have been returned with the end of expedition 12 and 13.Comment: Accepted for publication on Advances in Space Research http://dx.doi.org/10.1016/j.asr.2007.04.03

The very red afterglow of GRB 000418 - further evidence for dust extinction in a GRB host galaxy

We report near-infrared and optical follow-up observations of the afterglow of the Gamma-Ray Burst 000418 starting 2.5 days after the occurrence of the burst and extending over nearly seven weeks. GRB 000418 represents the second case for which the afterglow was initially identified by observations in the near-infrared. During the first 10 days its R-band afterglow was well characterized by a single power-law decay with a slope of 0.86. However, at later times the temporal evolution of the afterglow flattens with respect to a simple power-law decay. Attributing this to an underlying host galaxy we find its magnitude to be R=23.9 and an intrinsic afterglow decay slope of 1.22. The afterglow was very red with R-K=4 mag. The observations can be explained by an adiabatic, spherical fireball solution and a heavy reddening due to dust extinction in the host galaxy. This supports the picture that (long) bursts are associated with events in star-forming regions.Comment: Accepted for publication in The Astrophysical Journal. 12 pages; citations & references updated; minor textual change